Author
Listed:
- Po-Jen Yang
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan
These authors contributed equally to the work.)
- Ming-Ju Hsieh
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Cancer Research Center, Changhua Christian Hospital, Changhua 500, Taiwan
Graduate Institute of Biomedical Sciences, China Medical University, Taichung 404, Taiwan
These authors contributed equally to the work.)
- Tung-Wei Hung
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Division of Nephrology, Department of Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)
- Shian-Shiang Wang
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Division of Urology, Department of Surgery, Taichung Veterans General Hospital, Taichung 407, Taiwan)
- Shiuan-Chih Chen
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Department of Family and Community Medicine, Chung Shan Medical University Hospital, Taichung 402, Taiwan)
- Meng-Chih Lee
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Department of Family Medicine, Taichung Hospital, Ministry of Health and Welfare, Taichung 403, Taiwan)
- Shun-Fa Yang
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)
- Ying-Erh Chou
(Institute of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
School of Medicine, Chung Shan Medical University, Taichung 402, Taiwan
Department of Medical Research, Chung Shan Medical University Hospital, Taichung 402, Taiwan)
Abstract
Urothelial cell carcinoma (UCC) is one of the major malignancies of the genitourinary tract, and it is induced by carcinogenic epidemiological risk factors. H19 is one of the most crucial long noncoding RNAs (lncRNAs) and is involved in various types of bladder cancer. In this study, we examined H19 single-nucleotide polymorphisms (SNPs) to investigate UCC susceptibility and clinicopathological characteristics. Using real-time polymerase chain reaction, we analyzed five SNPs of H19 in 431 UCC patients and 431 controls without cancer. The results showed that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants had a high risk of developing muscle invasive tumors (pT2–T4) ( p = 0.030; p = 0.025, respectively). With a median follow up of 39 months, CT+TT polymorphisms of rs2107425 were associated with worse disease-specific survival (adjusted hard ratio (AHR) = 2.043, 95% confidence interval (CI) = 1.029-4.059) in UCC patients aged older than 65 years. In conclusion, our results indicate that patients with UCC carrying the H19 rs217727 CT + TT and rs2107425 CT + TT genetic variants have a high risk of developing muscle invasive tumors. Thus, H19 polymorphisms may be applied as a marker or therapeutic target in UCC treatment.
Suggested Citation
Po-Jen Yang & Ming-Ju Hsieh & Tung-Wei Hung & Shian-Shiang Wang & Shiuan-Chih Chen & Meng-Chih Lee & Shun-Fa Yang & Ying-Erh Chou, 2019.
"Effects of Long Noncoding RNA H19 Polymorphisms on Urothelial Cell Carcinoma Development,"
IJERPH, MDPI, vol. 16(8), pages 1-10, April.
Handle:
RePEc:gam:jijerp:v:16:y:2019:i:8:p:1322-:d:222338
Download full text from publisher
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:16:y:2019:i:8:p:1322-:d:222338. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
We have no bibliographic references for this item. You can help adding them by using this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.