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Metabolic Syndrome and Coronary Artery Disease Risk: A Meta-Analysis of Observational Studies

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  • Amal F. Alshammary

    (Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia)

  • Khalid Khalaf Alharbi

    (Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia)

  • Naif Jameel Alshehri

    (Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia)

  • Vishal Vennu

    (Department of Rehabilitation Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia)

  • Imran Ali Khan

    (Department of Clinical Laboratory Sciences, College of Applied Medical Sciences, King Saud University, Riyadh 11433, Saudi Arabia)

Abstract

Although numerous studies have described the link between metabolic syndrome (MetS) and Coronary Artery Disease (CAD), no meta-analysis has been carried out on this relationship. Thus, the present study intended to address this limitation. A systematic search was carried out using electronic databases, such as PubMed, CINAHL Plus, Medline, and Web of Science. A sum of 10 studies ( n = 9327) was incorporated in the meta-analysis. Compared with non-MetS, MetS was significantly associated with high CAD risk (OR = 4.03, 95% CI = 3.56–4.56). The MetS components were also significantly correlated with high CAD risk (OR = 3.72, 95% CI = 3.22–4.40). The presence of two (OR = 3.93, 95% CI = 2.81–5.49), three (OR = 4.09, 95% CI = 2.85–5.86), four (OR = 4.04, 95% CI = 2.83–5.78), or all five MetS components (OR = 3.92, 95% CI = 3.11–4.93), were significantly associated with a high risk of CAD. MetS and its individual or combined elements were linked with high CAD risk based on contemporary evidence. Thus, the assessment of MetS and its components might help identify people at a higher risk of advancing CAD in the future.

Suggested Citation

  • Amal F. Alshammary & Khalid Khalaf Alharbi & Naif Jameel Alshehri & Vishal Vennu & Imran Ali Khan, 2021. "Metabolic Syndrome and Coronary Artery Disease Risk: A Meta-Analysis of Observational Studies," IJERPH, MDPI, vol. 18(4), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:4:p:1773-:d:497882
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    References listed on IDEAS

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    1. Jonathan A.C. Sterne & Roger M. Harbord, 2004. "Funnel plots in meta-analysis," Stata Journal, StataCorp LP, vol. 4(2), pages 127-141, June.
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    1. Andrea Higuera-Gómez & Rosa Ribot-Rodríguez & Victor Micó & Amanda Cuevas-Sierra & Rodrigo San Cristóbal & Jose Alfredo Martínez, 2022. "Lifestyle and Health-Related Quality of Life Relationships Concerning Metabolic Disease Phenotypes on the Nutrimdea Online Cohort," IJERPH, MDPI, vol. 20(1), pages 1-19, December.
    2. José E. Teixeira & José A. Bragada & João P. Bragada & Joana P. Coelho & Isabel G. Pinto & Luís P. Reis & Paula O. Fernandes & Jorge E. Morais & Pedro M. Magalhães, 2022. "Structural Equation Modelling for Predicting the Relative Contribution of Each Component in the Metabolic Syndrome Status Change," IJERPH, MDPI, vol. 19(6), pages 1-14, March.
    3. Pedro Forte & Luís Branquinho & Ricardo Ferraz, 2022. "The Relationships between Physical Activity, Exercise, and Sport on the Immune System," IJERPH, MDPI, vol. 19(11), pages 1-6, June.

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