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Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season

Author

Listed:
  • Ainara Mira-Iglesias

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Equally contributed.)

  • F. Xavier López-Labrador

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Consorcio de Investigación Biomédica de Epidemiología y Salud Pública (CIBERESP), Instituto de Salud Carlos III, 28029 Madrid, Spain
    Equally contributed.)

  • Javier García-Rubio

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

  • Beatriz Mengual-Chuliá

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

  • Miguel Tortajada-Girbés

    (Hospital Universitario Doctor Peset, 46017 Valencia, Spain)

  • Joan Mollar-Maseres

    (Hospital Universitario y Politécnico La Fe, 46026 Valencia, Spain)

  • Mario Carballido-Fernández

    (Hospital General Universitario de Castellón, 12004 Castellón, Spain
    Departamento Medicina, Universidad CEU Cardenal Herrera, 12006 Castellón, Spain)

  • Germán Schwarz-Chavarri

    (Hospital General Universitario de Alicante, 03010 Alicante, Spain)

  • Joan Puig-Barberà

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain
    Centro de Salud Pública de Castellón, 12003 Castellón, Spain)

  • Javier Díez-Domingo

    (Fundación Para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana (FISABIO-Public Health), 46020 Valencia, Spain)

Abstract

Influenza vaccination is annually recommended for specific populations at risk, such as older adults. We estimated the 2018/2019 influenza vaccine effectiveness (IVE) overall, by influenza subtype, type of vaccine, and by time elapsed since vaccination among subjects 65 years old or over in a multicenter prospective study in the Valencia Hospital Surveillance Network for the Study of Influenza and other Respiratory Viruses (VAHNSI, Spain). Information about potential confounders was obtained from clinical registries and/or by interviewing patients and vaccination details were only ascertained by registries. A test-negative design was performed in order to estimate IVE. As a result, IVE was estimated at 46% (95% confidence interval (CI): (16%, 66%)), 41% (95% CI: (−34%, 74%)), and 45% (95% CI: (7%, 67%)) against overall influenza, A(H1N1)pdm09 and A(H3N2), respectively. An intra-seasonal not relevant waning effect was detected. The IVE for the adjuvanted vaccine in ≥75 years old was 45% (2%, 69%) and for the non-adjuvanted vaccine in 65–74 years old was 59% (−16%, 86%). Thus, our data revealed moderate vaccine effectiveness against influenza A(H3N2) and not significant against A(H1N1)pdm09. Significant protection was conferred by the adjuvanted vaccine to patients ≥75 years old. Moreover, an intra-seasonal not relevant waning effect was detected, and a not significant IVE decreasing trend was observed over time.

Suggested Citation

  • Ainara Mira-Iglesias & F. Xavier López-Labrador & Javier García-Rubio & Beatriz Mengual-Chuliá & Miguel Tortajada-Girbés & Joan Mollar-Maseres & Mario Carballido-Fernández & Germán Schwarz-Chavarri & , 2021. "Influenza Vaccine Effectiveness and Waning Effect in Hospitalized Older Adults. Valencia Region, Spain, 2018/2019 Season," IJERPH, MDPI, vol. 18(3), pages 1-19, January.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:3:p:1129-:d:488251
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    References listed on IDEAS

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    1. Greenland, S., 1989. "Modeling and variable selection in epidemiologic analysis," American Journal of Public Health, American Public Health Association, vol. 79(3), pages 340-349.
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