IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i23p12490-d689415.html
   My bibliography  Save this article

Effects of Mixed of a Ketogenic Diet in Overweight and Obese Women with Polycystic Ovary Syndrome

Author

Listed:
  • Raffaele Ivan Cincione

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Francesca Losavio

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Fabiana Ciolli

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Anna Valenzano

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Giuseppe Cibelli

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Giovanni Messina

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy)

  • Rita Polito

    (Department of Clinical and Experimental Medicine, University of Foggia, 71100 Foggia, Italy
    Department of Advanced Medical and Surgical Sciences, Università degli Studi della Campania “Luigi Vanvitelli”, 80138 Napoli, Italy)

Abstract

Polycystic ovary syndrome (PCOS) is a commonly occurring endocrine disorder characterized by hirsutism, anovulation, and polycystic ovaries. Often comorbid with insulin resistance, dyslipidemia, and obesity, it also carries significant risk for the development of cardiovascular and metabolic sequelae, including diabetes and metabolic syndrome. The relationship between central obesity and the development of insulin resistance is widely verified. Adipose tissue excess and the coexistent dysregulation of adipocyte functions directly contribute to the pathogenesis of the metabolic complications observed in women with PCOS. In the light of these evidence, the most therapeutic option prescribed to obese women with PCOS, regardless of the phenotype e from the severity of clinical expression, is lifestyle correction by diet and physical activity. The aim of this study is to evaluate the beneficial effects of ketogenic diet in 17 obese women with PCOS. Our results showed that the ketogenic diet inducing therapeutic ketosis, improves the anthropometric and many biochemical parameters such as LH, FSH, SHBG, insulin sensitivity and HOMA index. In addition, it induces a reduction in androgenic production, whereas the contextual reduction of fat mass reduced the acyclic production of estrogens deriving from the aromatization in the adipose tissue of the androgenic excess, with an improvement of the LH/FSH ratio. This is the first study on the effects of the ketogenic diet on PCOS, however, further studies are needed to elucidate the mechanism underlying ketogenic diet effects.

Suggested Citation

  • Raffaele Ivan Cincione & Francesca Losavio & Fabiana Ciolli & Anna Valenzano & Giuseppe Cibelli & Giovanni Messina & Rita Polito, 2021. "Effects of Mixed of a Ketogenic Diet in Overweight and Obese Women with Polycystic Ovary Syndrome," IJERPH, MDPI, vol. 18(23), pages 1-14, November.
  • Handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12490-:d:689415
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/23/12490/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/18/23/12490/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Roberta Zupo & Fabio Castellana & Rodolfo Sardone & Annamaria Sila & Vito Angelo Giagulli & Vincenzo Triggiani & Raffaele Ivan Cincione & Gianluigi Giannelli & Giovanni De Pergola, 2020. "Preliminary Trajectories in Dietary Behaviors during the COVID-19 Pandemic: A Public Health Call to Action to Face Obesity," IJERPH, MDPI, vol. 17(19), pages 1-15, September.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Agnieszka Gruszecka-Kosowska & Katarzyna Mazur-Włodarczyk & Agata Wódkowska, 2023. "Native vs. Unique Fruit Popularity: Exploring the Sustainable Fruit Consumption in Poland—Research Report," Sustainability, MDPI, vol. 15(14), pages 1-23, July.
    2. Nisreen M. Abdulsalam & Najla A. Khateeb & Sarah S. Aljerbi & Waad M. Alqumayzi & Shaima S. Balubaid & Atheer A. Almarghlani & Amira A. Ayad & Leonard L. Williams, 2021. "Assessment of Dietary Habits and Physical Activity Changes during the Full COVID-19 Curfew Period and Its Effect on Weight among Adults in Jeddah, Saudi Arabia," IJERPH, MDPI, vol. 18(16), pages 1-13, August.
    3. Corinne E. Gautreaux & Kristen S. Smith & Luke Dolan & Michael B. Marlin & Michael W. Greene & Josh R. Novak & Andrew D. Frugé, 2022. "Early Pandemic Improvements in Diet Quality Are Associated with Increased Physical Activity and Weight Loss in US Adults," IJERPH, MDPI, vol. 19(14), pages 1-9, July.
    4. Zhengyan Liang & Derong Kang & Minqiang Zhang & Yuanlin Xia & Qing Zeng, 2021. "The Impact of the COVID-19 Pandemic on Chinese Postgraduate Students’ Mental Health," IJERPH, MDPI, vol. 18(21), pages 1-12, November.
    5. Margherita Micheletti Cremasco & Anna Mulasso & Alessia Moroni & Andrea Testa & Raffaella Degan & Alberto Rainoldi & Emanuela Rabaglietti, 2021. "Relation among Perceived Weight Change, Sedentary Activities and Sleep Quality during COVID-19 Lockdown: A Study in an Academic Community in Northern Italy," IJERPH, MDPI, vol. 18(6), pages 1-14, March.
    6. Christian R. Mejia & Bertha Farfán & Jorge A. Figueroa-Tarrillo & Kely Palomino & César Johan Pereira-Victorio & Virgilio E. Failoc-Rojas & Mario J. Valladares-Garrido, 2023. "Factors Associated with Perceived Change in Weight, Physical Activity, and Food Consumption during the COVID-19 Lockdown in Latin America," Sustainability, MDPI, vol. 15(3), pages 1-13, January.
    7. Natascha Mojtahedzadeh & Felix Alexander Neumann & Elisabeth Rohwer & Albert Nienhaus & Matthias Augustin & Volker Harth & Birgit-Christiane Zyriax & Stefanie Mache, 2021. "The Health Behaviour of German Outpatient Caregivers in Relation to the COVID-19 Pandemic: A Mixed-Methods Study," IJERPH, MDPI, vol. 18(15), pages 1-30, August.
    8. Alice Freiberg & Melanie Schubert & Karla Romero Starke & Janice Hegewald & Andreas Seidler, 2021. "A Rapid Review on the Influence of COVID-19 Lockdown and Quarantine Measures on Modifiable Cardiovascular Risk Factors in the General Population," IJERPH, MDPI, vol. 18(16), pages 1-46, August.
    9. Iwona Kowalczuk & Jerzy Gębski, 2021. "Impact of Fear of Contracting COVID-19 and Complying with the Rules of Isolation on Nutritional Behaviors of Polish Adults," IJERPH, MDPI, vol. 18(4), pages 1-12, February.
    10. Cristina González-Monroy & Irene Gómez-Gómez & Cristian M. Olarte-Sánchez & Emma Motrico, 2021. "Eating Behaviour Changes during the COVID-19 Pandemic: A Systematic Review of Longitudinal Studies," IJERPH, MDPI, vol. 18(21), pages 1-24, October.
    11. María del Pilar Montero López & Ana Isabel Mora Urda & Francisco Javier Martín Almena & Oscar Geovanny Enríquez-Martínez, 2022. "Changes in Eating Behaviors during the COVID-19 Lockdown and the Impact on the Potential Inflammatory Effects of Diet," IJERPH, MDPI, vol. 19(15), pages 1-17, July.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:23:p:12490-:d:689415. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.