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Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T + Itpr3 tf /J Mice

Author

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  • Caterina Franco

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy)

  • Francesca Bonomini

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
    Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs-(ARTO)”, University of Brescia, 25123 Brescia, Italy
    Italian Society of Orofacial Pain (SISDO), 25123 Brescia, Italy)

  • Elisa Borsani

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
    Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs-(ARTO)”, University of Brescia, 25123 Brescia, Italy
    Italian Society of Orofacial Pain (SISDO), 25123 Brescia, Italy)

  • Stefania Castrezzati

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy)

  • Lorenzo Franceschetti

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy)

  • Rita Rezzani

    (Anatomy and Physiopathology Division, Department of Clinical and Experimental Sciences, University of Brescia, 25123 Brescia, Italy
    Interdipartimental University Center of Research “Adaption and Regeneration of Tissues and Organs-(ARTO)”, University of Brescia, 25123 Brescia, Italy
    Italian Society of Orofacial Pain (SISDO), 25123 Brescia, Italy)

Abstract

Autism spectrum disorder is a neurodevelopmental syndrome with a complicated etiology and could be responsible for disrupted gastrointestinal tract microbiota. The aim of this work was to study intestinal samples from an autistic animal model (BTBR mouse strain) to better describe gastrointestinal alterations. We performed a morphological and biological evaluation of small intestine samples. In terms of morphology, we studied the goblet cells, cells of intestinal mucosal responsible for the production and maintenance of the protective mucous blanket. Alterations in their secretion may indicate an altered rate of mucus synthesis and this is one of the possible causes of gastrointestinal problems. In terms of biological evaluation, impaired regulation of glucose homeostasis regulated by sodium-glucose transporters has been suggested as an important component of obesity and associated comorbidities; therefore, this study analyzed the expression of sodium/glucose transporter-1 and -3 in BTBR mice to better define their role. We demonstrated that, in BTBR mice as compared to C57BL/6J (B6) strain animals: (1) The goblet cells had different protein content in their vesicles and apparently a larger number of Golgi cisternae; (2) the expression and level of sodium/glucose transporters were higher. These findings could suggest new possible targets in autism spectrum disorder to maintain mucus barrier function.

Suggested Citation

  • Caterina Franco & Francesca Bonomini & Elisa Borsani & Stefania Castrezzati & Lorenzo Franceschetti & Rita Rezzani, 2021. "Involvement of Intestinal Goblet Cells and Changes in Sodium Glucose Transporters Expression: Possible Therapeutic Targets in Autistic BTBR T + Itpr3 tf /J Mice," IJERPH, MDPI, vol. 18(21), pages 1-15, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:21:p:11328-:d:667075
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    References listed on IDEAS

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    1. Lin, Biing-Hwan & Morrison, Rosanna Mentzer, 2002. "Higher Fruit Consumption Linked With Lower Body Mass Index," Food Review/ National Food Review, United States Department of Agriculture, Economic Research Service, vol. 25(3), pages 1-5.
    2. Jeremiah R. McDole & Leroy W. Wheeler & Keely G. McDonald & Baomei Wang & Vjollca Konjufca & Kathryn A. Knoop & Rodney D. Newberry & Mark J. Miller, 2012. "Goblet cells deliver luminal antigen to CD103+ dendritic cells in the small intestine," Nature, Nature, vol. 483(7389), pages 345-349, March.
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