IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i20p10828-d656912.html
   My bibliography  Save this article

Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China

Author

Listed:
  • Shangmin Chen

    (Injury Prevention Research Center, Shantou University Medical College, Shantou 515041, China
    School of Public Health, Shantou University, Shantou 515041, China)

  • Weicong Cai

    (Injury Prevention Research Center, Shantou University Medical College, Shantou 515041, China
    Shenzhen Center for Chronic Disease Control, Shenzhen 518020, China)

  • Shiwei Duan

    (Medical Genetics Center, School of Medicine, Ningbo University, Ningbo 315211, China)

  • Lijie Gao

    (Department of Epidemiology, Shandong University School of Public Health, Jinan 250012, China)

  • Wenda Yang

    (Injury Prevention Research Center, Shantou University Medical College, Shantou 515041, China)

  • Yang Gao

    (Department of Sport and Physical Education, Hong Kong Baptist University, Kowloon Tong, Hong Kong 999077, China)

  • Cunxian Jia

    (Department of Epidemiology, Shandong University School of Public Health, Jinan 250012, China)

  • Hongjuan Zhang

    (School of Physical Education, Shanxi Normal University, Linfen 041000, China)

  • Liping Li

    (Injury Prevention Research Center, Shantou University Medical College, Shantou 515041, China
    School of Public Health, Shantou University, Shantou 515041, China)

Abstract

The catechol-O-methyltransferase (COMT) is a candidate gene to provide promising evidence of psychiatric disorders, but there is a knowledge gap between the genetic factor and multiple physical activity-related injuries (PARIs). The aim of this study was to explore the contribution of COMT to the risk of PARIs among university students in the Chinese Han population. We can further search for the intrinsic risk factors for the occurrence of multiple physical activity injuries and provide a scientific basis for early screening and precise intervention for the high-risk group of college students with multiple PARIs. A 1:1 matched case-control study of 61 PARIs cases and 61 healthy controls were carried out. DNA samples of the participants were isolated from saliva and genotyped on eight SNPs of the COMT gene (rs9265, rs4680, rs6269, rs4818, rs4633, rs165655, rs165656, and rs165722) using the MALDI-TOF MS method. We found that rs6269 and rs4818 were significantly associated with PARIs, and rs6269-GG and rs4818-GG contributed to the reduced risk of PARIs. Further haplotype analysis showed a four-marker C-G-C-G haplotype (rs165722-rs6269-rs4633-rs4818) acted with a protective role in the development of PARIs ( p = 0.037; OR: 0.474, 95% CI: 0.269 to 0.834). However, the interactions between club membership and rs6269 or rs4818 would significantly increase the risk of PARIs (both p < 0.001, OR: 5.121 and 4.977, respectively). This is the first study to find the contribution of COMT to PARIs occurrence, suggesting that the COMT polymorphisms and the gene–environment interactions may alter the risk of PARIs.

Suggested Citation

  • Shangmin Chen & Weicong Cai & Shiwei Duan & Lijie Gao & Wenda Yang & Yang Gao & Cunxian Jia & Hongjuan Zhang & Liping Li, 2021. "Association of COMT Polymorphisms with Multiple Physical Activity-Related Injuries among University Students in China," IJERPH, MDPI, vol. 18(20), pages 1-14, October.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10828-:d:656912
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/20/10828/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/20/10828/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Weicong Cai & Yang Gao & Wenda Yang & Fuyuan Cheng & Dongchun Tang & Liping Li, 2018. "Physical Activity-Related Injury and Its Associated Factors among Middle School Students in Southern China," IJERPH, MDPI, vol. 15(6), pages 1-12, June.
    2. Gwowen Shieh, 2018. "Power and sample size calculations for comparison of two regression lines with heterogeneous variances," PLOS ONE, Public Library of Science, vol. 13(12), pages 1-14, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Liyi Ding & Britton W. Brewer & Marcia Mackey & Hao Cai & Jianqiang Zhang & Yudong Song & Qunhui Cai, 2022. "Factors Associated with School Sports Injury among Elementary and Middle School Students in Shanghai, China," IJERPH, MDPI, vol. 19(11), pages 1-11, May.
    2. Eva Ursej & Damir Sekulic & Dasa Prus & Goran Gabrilo & Petra Zaletel, 2019. "Investigating the Prevalence and Predictors of Injury Occurrence in Competitive Hip Hop Dancers: Prospective Analysis," IJERPH, MDPI, vol. 16(17), pages 1-14, September.
    3. Mohamed Ahmed Said & Amnah Ahmed Almatar & Mohammed Shaab Alibrahim, 2023. "Higher Sedentary Behaviors and Lower Levels of Specific Knowledge Are Risk Factors for Physical Activity-Related Injuries in Saudi Adolescents," IJERPH, MDPI, vol. 20(5), pages 1-19, March.
    4. Richard Gyan Aboagye & Abdul-Aziz Seidu & Samuel Adolf Bosoka & John Elvis Hagan & Bright Opoku Ahinkorah, 2021. "Prevalence and Correlates of Unintentional Injuries among In-School Adolescents in Ghana," IJERPH, MDPI, vol. 18(13), pages 1-13, June.
    5. Ju-Pil Choe & Ji-Su Kim & Jeong-Hui Park & Eunhye Yoo & Jung-Min Lee, 2021. "When Do Individuals Get More Injured? Relationship between Physical Activity Intensity, Duration, Participation Mode, and Injury," IJERPH, MDPI, vol. 18(20), pages 1-15, October.
    6. Dongchun Tang & Weicong Cai & Wenda Yang & Yang Gao & Liping Li, 2019. "Gender-Specific Risk Factors of Physical Activity-Related Injuries among Middle School Students in Southern China," IJERPH, MDPI, vol. 16(13), pages 1-13, July.
    7. Weicong Cai & Yan Sun & Ke Peng & Heather Kwok & Lin Lei & Shing Wu & Chi Kei Lam & Liping Li & Yang Gao, 2020. "Physical Activity-Related Injuries and Risk Factors among Secondary School Students in Hong Kong," IJERPH, MDPI, vol. 17(3), pages 1-11, January.
    8. Dongchun Tang & Weicong Cai & Wenda Yang & Shangmin Chen & Liping Li, 2022. "Effectiveness of Health-Related Behavior Interventions on Physical Activity-Related Injuries in Junior Middle School Students," IJERPH, MDPI, vol. 19(7), pages 1-12, March.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:20:p:10828-:d:656912. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.