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Reductive carboxylation supports redox homeostasis during anchorage-independent growth

Author

Listed:
  • Lei Jiang

    (Children’s Medical Center Research Institute, UT Southwestern Medical Center)

  • Alexander A. Shestov

    (University of Pennsylvania School of Medicine)

  • Pamela Swain

    (Seahorse Bioscience)

  • Chendong Yang

    (Children’s Medical Center Research Institute, UT Southwestern Medical Center)

  • Seth J. Parker

    (University of California)

  • Qiong A. Wang

    (Touchstone Diabetes Center, UT Southwestern Medical Center)

  • Lance S. Terada

    (UT Southwestern Medical Center)

  • Nicholas D. Adams

    (GlaxoSmithKline)

  • Michael T. McCabe

    (GlaxoSmithKline)

  • Beth Pietrak

    (GlaxoSmithKline)

  • Stan Schmidt

    (GlaxoSmithKline)

  • Christian M. Metallo

    (University of California)

  • Brian P. Dranka

    (Seahorse Bioscience)

  • Benjamin Schwartz

    (GlaxoSmithKline)

  • Ralph J. DeBerardinis

    (Children’s Medical Center Research Institute, UT Southwestern Medical Center
    UT Southwestern Medical Center
    McDermott Center for Human Growth and Development, UT Southwestern Medical Center)

Abstract

Malignant cells are able to survive and grow in detached conditions, despite the associated increase in reactive oxygen species; here a novel metabolic pathway used by cancer cells as they adapt to anchorage-independent growth is described.

Suggested Citation

  • Lei Jiang & Alexander A. Shestov & Pamela Swain & Chendong Yang & Seth J. Parker & Qiong A. Wang & Lance S. Terada & Nicholas D. Adams & Michael T. McCabe & Beth Pietrak & Stan Schmidt & Christian M. , 2016. "Reductive carboxylation supports redox homeostasis during anchorage-independent growth," Nature, Nature, vol. 532(7598), pages 255-258, April.
    • Handle: RePEc:nat:nature:v:532:y:2016:i:7598:d:10.1038_nature17393
    DOI: 10.1038/nature17393
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    Cited by:

    1. Karl K. Krull & Syed Azmal Ali & Jeroen Krijgsveld, 2024. "Enhanced feature matching in single-cell proteomics characterizes IFN-γ response and co-existence of cell states," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    2. Soeun Kang & Maciek R. Antoniewicz & Nissim Hay, 2024. "Metabolic and transcriptomic reprogramming during contact inhibition-induced quiescence is mediated by YAP-dependent and YAP-independent mechanisms," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    3. Eleonora Di Piazza & Elisabetta Pandolfi & Ilaria Cacciotti & Andrea Del Fattore & Alberto Eugenio Tozzi & Aurelio Secinaro & Luca Borro, 2021. "Bioprinting Technology in Skin, Heart, Pancreas and Cartilage Tissues: Progress and Challenges in Clinical Practice," IJERPH, MDPI, vol. 18(20), pages 1-29, October.
    4. C. Megan Young & Laurent Beziaud & Pierre Dessen & Angela Madurga Alonso & Albert Santamaria-Martínez & Joerg Huelsken, 2023. "Metabolic dependencies of metastasis-initiating cells in female breast cancer," Nature Communications, Nature, vol. 14(1), pages 1-18, December.
    5. Jiang-jiang Li & Tiantian Yu & Peiting Zeng & Jingyu Tian & Panpan Liu & Shuang Qiao & Shijun Wen & Yumin Hu & Qiao Liu & Wenhua Lu & Hui Zhang & Peng Huang, 2024. "Wild-type IDH2 is a therapeutic target for triple-negative breast cancer," Nature Communications, Nature, vol. 15(1), pages 1-17, December.

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