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Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial

Author

Listed:
  • Gerardo Bosco

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Matteo Paganini

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Tommaso Antonio Giacon

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Alberto Oppio

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Alessandra Vezzoli

    (Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy)

  • Cinzia Dellanoce

    (Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy)

  • Tatiana Moro

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Antonio Paoli

    (Department of Biomedical Sciences, University of Padova, 35131 Padova, Italy)

  • Federica Zanotti

    (Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy)

  • Barbara Zavan

    (Department of Medical Sciences, University of Ferrara, 44121 Ferrara, Italy)

  • Costantino Balestra

    (Environmental, Occupational, Ageing (Integrative) Physiology Laboratory, Haute Ecole Bruxelles-Brabant (HE2B), 1180 Brussels, Belgium)

  • Simona Mrakic-Sposta

    (Institute of Clinical Physiology, National Research Council (CNR), 20162 Milan, Italy)

Abstract

Exercise generates reactive oxygen species (ROS), creating a redox imbalance towards oxidation when inadequately intense. Normobaric and hyperbaric oxygen (HBO) breathed while not exercising induces antioxidant enzymes expression, but literature is still poor. Twenty-two athletes were assigned to five groups: controls; 30%, or 50% O 2 ; 100% O 2 (HBO) at 1.5 or 2.5 atmosphere absolute (ATA). Twenty treatments were administered on non-training days. Biological samples were collected at T0 (baseline), T1 (end of treatments), and T2 (1 month after) to assess ROS, antioxidant capacity (TAC), lipid peroxidation, redox (amino-thiols) and inflammatory (IL-6, 10, TNF-α) status, renal function (i.e., neopterin), miRNA, and hemoglobin. At T1, O 2 mixtures and HBO induced an increase of ROS, lipid peroxidation and decreased TAC, counterbalanced at T2. Furthermore, 50% O 2 and HBO treatments determined a reduced state in T2. Neopterin concentration increased at T1 breathing 50% O 2 and HBO at 2.5 ATA. The results suggest that 50% O 2 treatment determined a reduced state in T2; HBO at 1.5 and 2.5 ATA similarly induced protective mechanisms against ROS, despite the latter could expose the body to higher ROS levels and neopterin concentrations. HBO resulted in increased Hb levels and contributed to immunomodulation by regulating interleukin and miRNA expression.

Suggested Citation

  • Gerardo Bosco & Matteo Paganini & Tommaso Antonio Giacon & Alberto Oppio & Alessandra Vezzoli & Cinzia Dellanoce & Tatiana Moro & Antonio Paoli & Federica Zanotti & Barbara Zavan & Costantino Balestra, 2021. "Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial," IJERPH, MDPI, vol. 18(18), pages 1-17, September.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:18:p:9755-:d:636781
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    References listed on IDEAS

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    1. Simona Mrakic-Sposta & Alessandra Vezzoli & Federica D’Alessandro & Matteo Paganini & Cinzia Dellanoce & Danilo Cialoni & Gerardo Bosco, 2020. "Change in Oxidative Stress Biomarkers During 30 Days in Saturation Dive: A Pilot Study," IJERPH, MDPI, vol. 17(19), pages 1-10, September.
    2. Jinhee Woo & Jae-Hee Min & Yul-Hyo Lee & Hee-Tae Roh, 2020. "Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study," IJERPH, MDPI, vol. 17(20), pages 1-10, October.
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    Cited by:

    1. Morgan Levenez & Kate Lambrechts & Simona Mrakic-Sposta & Alessandra Vezzoli & Peter Germonpré & Hadrien Pique & Fabio Virgili & Gerardo Bosco & Pierre Lafère & Costantino Balestra, 2022. "Full-Face Mask Use during SCUBA Diving Counters Related Oxidative Stress and Endothelial Dysfunction," IJERPH, MDPI, vol. 19(2), pages 1-14, January.

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