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Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study

Author

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  • Jinhee Woo

    (Department of Physical Education, College of Arts and Physical Education, Dong-A University, Busan 49315, Korea
    The first two authors contributed equally to this work.)

  • Jae-Hee Min

    (Department of Physical Education, College of Arts and Physical Education, Dong-A University, Busan 49315, Korea
    The first two authors contributed equally to this work.)

  • Yul-Hyo Lee

    (Department of Taekwondo, Youngsan University, Yangsan-si 50510, Korea)

  • Hee-Tae Roh

    (Department of Physical Education, College of Arts and Physical Education, Dong-A University, Busan 49315, Korea)

Abstract

The purpose of this study was to investigate the effects of hyperbaric oxygen therapy (HBOT) on inflammation, the oxidative/antioxidant balance, and muscle damage after acute exercise in normobaric, normoxic (NN) and hypobaric, hypoxic (HH) environments. Eighteen healthy males were selected and randomly assigned to three groups: exercise in NN conditions (NN group, n = 6), HBOT treatment after exercise in NN conditions (HNN group, n = 6), and HBOT treatment after exercise in HH conditions (HHH group, n = 6). All subjects performed treadmill running for 60 min at 75–80% maximum heart rate (HRmax) exercise intensity under each condition. The HBOT treatments consisted of breathing 100% oxygen at 2.5 atmosphere absolute (ATA) for 60 min. Blood samples were collected before exercise (BE), after exercise (AE), and after HBOT (AH) to examine inflammation (fibrinogen, interleukin-6 [IL-6], and tumor necrosis factor-α (TNF-α)), the oxidative/antioxidant balance (derivatives of reactive oxygen metabolites (d-ROMs) and the biological antioxidant potential (BAP)), and muscle damage (creatine kinase (CK) and lactate dehydrogenase (LDH)). Plasma fibrinogen, serum IL-6, CK, and LDH levels were significantly increased AE compared to BE in all groups ( p < 0.05). Plasma fibrinogen levels were significantly decreased AH compared to AE in all groups ( p < 0.05), and the HNN group had a significantly lower AH compared to BE ( p < 0.05). Serum IL-6 levels were significantly decreased AH compared to AE in the HNN and HHH groups ( p < 0.05). Serum CK levels were significantly decreased AH compared to AE in the HHH group ( p < 0.05). Serum LDH levels were significantly decreased AH compared to AE in the HNN and HHH groups ( p < 0.05), and the NN and HNN groups had significantly higher AH serum LDH levels compared to BE ( p < 0.05). These results suggest that acute exercise in both the NN and HH environments could induce temporary inflammatory responses and muscle damage, whereas HBOT treatment may be effective in alleviating exercise-induced inflammatory responses and muscle damage.

Suggested Citation

  • Jinhee Woo & Jae-Hee Min & Yul-Hyo Lee & Hee-Tae Roh, 2020. "Effects of Hyperbaric Oxygen Therapy on Inflammation, Oxidative/Antioxidant Balance, and Muscle Damage after Acute Exercise in Normobaric, Normoxic and Hypobaric, Hypoxic Environments: A Pilot Study," IJERPH, MDPI, vol. 17(20), pages 1-10, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:20:p:7377-:d:425661
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    References listed on IDEAS

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    1. Omar Boukhris & Khaled Trabelsi & Raouf Abdessalem & Hsen Hsouna & Achraf Ammar & Jordan M. Glenn & Nick Bott & Khadijah Irandoust & Morteza Taheri & Mouna Turki & Fatma Ayadi & Nicola L. Bragazzi & F, 2020. "Effects of the 5-m Shuttle Run Test on Markers of Muscle Damage, Inflammation, and Fatigue in Healthy Male Athletes," IJERPH, MDPI, vol. 17(12), pages 1-16, June.
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    Cited by:

    1. Gerardo Bosco & Matteo Paganini & Tommaso Antonio Giacon & Alberto Oppio & Alessandra Vezzoli & Cinzia Dellanoce & Tatiana Moro & Antonio Paoli & Federica Zanotti & Barbara Zavan & Costantino Balestra, 2021. "Oxidative Stress and Inflammation, MicroRNA, and Hemoglobin Variations after Administration of Oxygen at Different Pressures and Concentrations: A Randomized Trial," IJERPH, MDPI, vol. 18(18), pages 1-17, September.

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