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Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review

Author

Listed:
  • João Martins de Mello-Neto

    (School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia
    These two authors contributed equally.)

  • Jessica Gomes Rodrigues Nunes

    (Department of Periodontology, Faculty of Odontology, Rio de Janeiro State University, Rio de Janeiro 20551-030, Brazil
    These two authors contributed equally.)

  • Santosh Kumar Tadakamadla

    (School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia)

  • Carlos Marcelo da Silva Figueredo

    (School of Medicine and Dentistry, Menzies Health Institute Queensland, Griffith University, Gold Coast, QLD 4222, Australia)

Abstract

This systematic review assessed studies that evaluated the immunological traits of patients with both inflammatory bowel disease (IBD) and periodontal disease. An electronic search for literature was conducted on PubMed, Embase, Scopus, Cochrane and Web of Science. Studies that evaluated the immunological response in patients with IBD and periodontal disease were considered eligible for inclusion. A total of 6 cross-sectional studies of 275 patients were included. Immunological analyses were performed in gingival crevicular fluid, saliva, serum, intestinal and gingival biopsies. Four studies identified that the presence of IBD and periodontal disease was associated with higher levels of prostaglandin E2, aMMP8, IL-18 and S100A12, respectively, when compared to patients without the coexistence of both diseases. Furthermore, another study identified higher aMMP-8 levels with increasing severity of periodontitis in Crohn’s disease patients. The quality of overall evidence ranged from high to low due to the observational nature of contributing studies. The coexistence of IBD and periodontal disease seems to be associated with a more responsive inflammatory reaction compared with individuals having one or the other. More randomized controlled studies evaluating the coexistence of IBD and periodontitis are required to better explore the immunological interplay between them.

Suggested Citation

  • João Martins de Mello-Neto & Jessica Gomes Rodrigues Nunes & Santosh Kumar Tadakamadla & Carlos Marcelo da Silva Figueredo, 2021. "Immunological Traits of Patients with Coexistent Inflammatory Bowel Disease and Periodontal Disease: A Systematic Review," IJERPH, MDPI, vol. 18(17), pages 1-12, August.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:17:p:8958-:d:621903
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    References listed on IDEAS

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    1. David Moher & Alessandro Liberati & Jennifer Tetzlaff & Douglas G Altman & The PRISMA Group, 2009. "Preferred Reporting Items for Systematic Reviews and Meta-Analyses: The PRISMA Statement," PLOS Medicine, Public Library of Science, vol. 6(7), pages 1-6, July.
    2. Renata S. B. Fróes & Ana Teresa Pugas Carvalho & Antonio Jose V. Carneiro & Adriana Maria Hilu Barros Moreira & Jessica P. L. Moreira & Ronir R. Luiz & Heitor S. de Souza, 2018. "The socio-economic impact of work disability due to inflammatory bowel disease in Brazil," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 19(3), pages 463-470, April.
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