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Analysis of the Association between Female Medical History and Thyroid Cancer in Women: A Cross-Sectional Study Using KoGES HEXA Data

Author

Listed:
  • Young Ju Jin

    (Department of Otorhinolaryngology-Head & Neck Surgery, Wonkwang University Hospital, Wonkwang University College of Medicine, Iksan 54538, Korea)

  • Suk Woo Lee

    (Department of Obstetrics and Gynecology, Hallym University College of Medicine, Anyang 14068, Korea)

  • Chang Myeon Song

    (Department of Otolaryngology-Head and Neck Surgery, Hanyang University College of Medicine, Seoul 04763, Korea)

  • Bumjung Park

    (Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Korea)

  • Hyo Geun Choi

    (Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, Anyang 14068, Korea
    Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea)

Abstract

The purpose of this study was to evaluate the association between female medical history and thyroid cancer. Methods: Data from the Korean Genome and Epidemiology Study were collected from 2004 to 2016. Among a total of 1303 participants with thyroid cancer and 106,602 control (non-thyroid cancer) participants, the odds ratios (ORs) with 95% confidence intervals (CIs) of hysterectomy, oophorectomy, use of oral contraceptives, and number of children were evaluated. Results: The adjusted OR of hysterectomy for thyroid cancer was 1.73 (95% CI = 1.48–2.01, p < 0.001) in the minimally adjusted model. The adjusted ORs for thyroid cancer were 1.89 (95% CI = 1.06–3.37, p = 0.031), 0.89 (95% CI = 0.83–0.94, p < 0.001), and 0.85 (95% CI = 0.73–0.99, p = 0.040) for bilateral oophorectomy, number of children, and use of oral contraceptives, respectively, in the fully adjusted model. In the subgroup analysis, the adjusted ORs of bilateral oophorectomy were significant in the younger age (OR = 3.62, 95% CI = 1.45–9.03, p = 0.006), while the number of children was significant in the older age (OR = 0.86, 95% CI = 0.80–0.93, p < 0.001). Conclusions: The ORs of hysterectomy and bilateral oophorectomy were significantly higher in the thyroid cancer group in the younger age group. The adjusted ORs of the number of children were significantly low in the older age group.

Suggested Citation

  • Young Ju Jin & Suk Woo Lee & Chang Myeon Song & Bumjung Park & Hyo Geun Choi, 2021. "Analysis of the Association between Female Medical History and Thyroid Cancer in Women: A Cross-Sectional Study Using KoGES HEXA Data," IJERPH, MDPI, vol. 18(15), pages 1-9, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:15:p:8046-:d:604444
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    References listed on IDEAS

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    1. Maria Fiore & Gea Oliveri Conti & Rosario Caltabiano & Antonino Buffone & Pietro Zuccarello & Livia Cormaci & Matteo Angelo Cannizzaro & Margherita Ferrante, 2019. "Role of Emerging Environmental Risk Factors in Thyroid Cancer: A Brief Review," IJERPH, MDPI, vol. 16(7), pages 1-18, April.
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