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The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease

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  • Xiaming Du

    (Department of Orthopaedics, Shidong Hospital Affiliated to University of Shanghai for Science and Technology, Shanghai 200433, China
    Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China)

  • Chao Zhang

    (Xidu Community Health Service Center of Fengxian District, Shanghai 201400, China)

  • Xiangqi Zhang

    (Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China
    School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    School of Pharmacy, Shanghai Jiao Tong University, Shanghai 200240, China)

  • Zhen Qi

    (Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China)

  • Sulin Cheng

    (Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China
    School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Faculty of Sport and Health Sciences, University of Jyväskylä, 40014 Jyväskylä, Finland
    The Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China)

  • Shenglong Le

    (Exercise Translational Medicine Center, Shanghai Jiao Tong University, Shanghai 200240, China
    School of Life Sciences and Biotechnology, Shanghai Jiao Tong University, Shanghai 200240, China
    Faculty of Sport and Health Sciences, University of Jyväskylä, 40014 Jyväskylä, Finland
    The Key Laboratory of Systems Biomedicine, Ministry of Education, Shanghai Center for Systems Biomedicine, Shanghai Jiao Tong University, Shanghai 200240, China)

Abstract

This study investigated the impact of Nordic walking on bone properties in postmenopausal women with pre-diabetes and non-alcohol fatty liver disease (NAFLD). A total of 63 eligible women randomly participated in the Nordic walking training (AEx, n = 33), or maintained their daily lifestyle (Con, n = 30) during intervention. Bone mineral content (BMC) and density (BMD) of whole body (WB), total femur (TF), femoral neck (FN), and lumbar spine (L2-4) were assessed by dual-energy X-ray absorptiometry. Serum osteocalcin, pentosidine, receptor activator of nuclear factor kappa-B ligand (RANKL) levels were analyzed by ELISA assay. After an 8.6-month intervention, the AEx group maintained their BMC TF , BMD TF , BMC L2−4 , and BMD L2−4 , and increased their BMC FN ( p = 0.016), while the Con group decreased their BMC TF ( p = 0.008), BMD TF ( p = 0.001), and BMD L2−4 ( p = 0.002). However, no significant group × time interaction was observed, except for BMD L2−4 ( p = 0.013). Decreased pentosidine was correlated with increased BMC WB ( r = −0.352, p = 0.019). The intervention has no significant effect on osteocalcin and RANKL. Changing of bone mass was associated with changing of pentosidine, but not with osteocalcin and RANKL. Our results suggest that Nordic walking is effective in preventing bone loss among postmenopausal women with pre-diabetes and NAFLD.

Suggested Citation

  • Xiaming Du & Chao Zhang & Xiangqi Zhang & Zhen Qi & Sulin Cheng & Shenglong Le, 2021. "The Impact of Nordic Walking on Bone Properties in Postmenopausal Women with Pre-Diabetes and Non-Alcohol Fatty Liver Disease," IJERPH, MDPI, vol. 18(14), pages 1-10, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7570-:d:595378
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    References listed on IDEAS

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    1. Krystian Wochna & Alicja Nowak & Anna Huta-Osiecka & Katarzyna Sobczak & Zbigniew Kasprzak & Piotr Leszczyński, 2019. "Bone Mineral Density and Bone Turnover Markers in Postmenopausal Women Subjected to an Aqua Fitness Training Program," IJERPH, MDPI, vol. 16(14), pages 1-8, July.
    2. William J. Boyle & W. Scott Simonet & David L. Lacey, 2003. "Osteoclast differentiation and activation," Nature, Nature, vol. 423(6937), pages 337-342, May.
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    1. So-Young Kim & Dae-Myoung Yoo & Chanyang Min & Hyo-Geun Choi, 2021. "Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort," IJERPH, MDPI, vol. 18(16), pages 1-9, August.

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