IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v18y2021i14p7429-d592666.html
   My bibliography  Save this article

Children’s Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study

Author

Listed:
  • Kyung-Shin Lee

    (Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
    Environmental Health Center, Seoul National University College of Medicine, Seoul 03080, Korea
    These authors contributed equally to this work.)

  • Yoon-Jung Choi

    (Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
    Environmental Health Center, Seoul National University College of Medicine, Seoul 03080, Korea
    These authors contributed equally to this work.)

  • Jin-Woo Cho

    (Department of Statistics, University of Pittsburgh, Pittsburgh, PA 15260, USA)

  • Sung-Ji Moon

    (Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea)

  • Youn-Hee Lim

    (Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
    Section of Environmental Health, Department of Public Health, University of Copenhagen, 1014 Copenhagen, Denmark)

  • Johanna-Inhyang Kim

    (Department of Psychiatry, Hanyang University Medical Center, Seoul 04763, Korea)

  • Young-Ah Lee

    (Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, Korea)

  • Choong-Ho Shin

    (Department of Pediatrics, Seoul National University Children’s Hospital, Seoul National University College of Medicine, Seoul 03080, Korea)

  • Bung-Nyun Kim

    (Division of Children and Adolescent Psychiatry, Department of Psychiatry, Seoul National University Hospital, Seoul 03080, Korea)

  • Yun-Chul Hong

    (Department of Preventive Medicine, Seoul National University College of Medicine, Seoul 03080, Korea
    Environmental Health Center, Seoul National University College of Medicine, Seoul 03080, Korea
    Institute of Environmental Medicine, Seoul National University Medical Research Center, Seoul 03080, Korea)

Abstract

Epigenetics is known to be involved in regulatory pathways through which greenness exposure influences child development and health. We aimed to investigate the associations between residential surrounding greenness and DNA methylation changes in children, and further assessed the association between DNA methylation and children’s intelligence quotient (IQ) in a prospective cohort study. We identified cytosine-guanine dinucleotide sites (CpGs) associated with cognitive abilities from epigenome- and genome-wide association studies through a systematic literature review for candidate gene analysis. We estimated the residential surrounding greenness at age 2 using a geographic information system. DNA methylation was analyzed from whole blood using the HumanMethylationEPIC array in 59 children at age 2. We analyzed the association between greenness exposure and DNA methylation at age 2 at the selected CpGs using multivariable linear regression. We further investigated the relationship between DNA methylation and children’s IQ. We identified 8743 CpGs associated with cognitive ability based on the literature review. Among these CpGs, we found that 25 CpGs were significantly associated with greenness exposure at age 2, including cg26269038 (Bonferroni-corrected p ≤ 0.05) located in the body of SLC6A3 , which encodes a dopamine transporter. DNA methylation at cg26269038 at age 2 was significantly associated with children’s performance IQ at age 6. Exposure to surrounding greenness was associated with cognitive ability-related DNA methylation changes, which was also associated with children’s IQ. Further studies are warranted to clarify the epigenetic pathways linking greenness exposure and neurocognitive function.

Suggested Citation

  • Kyung-Shin Lee & Yoon-Jung Choi & Jin-Woo Cho & Sung-Ji Moon & Youn-Hee Lim & Johanna-Inhyang Kim & Young-Ah Lee & Choong-Ho Shin & Bung-Nyun Kim & Yun-Chul Hong, 2021. "Children’s Greenness Exposure and IQ-Associated DNA Methylation: A Prospective Cohort Study," IJERPH, MDPI, vol. 18(14), pages 1-16, July.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7429-:d:592666
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/18/14/7429/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/18/14/7429/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. P. Read Montague & Steven E. Hyman & Jonathan D. Cohen, 2004. "Computational roles for dopamine in behavioural control," Nature, Nature, vol. 431(7010), pages 760-767, October.
    2. Wolf Reik, 2007. "Stability and flexibility of epigenetic gene regulation in mammalian development," Nature, Nature, vol. 447(7143), pages 425-432, May.
    3. Joan A. Casey & Peter James & Kara E. Rudolph & Chih-Da Wu & Brian S. Schwartz, 2016. "Greenness and Birth Outcomes in a Range of Pennsylvania Communities," IJERPH, MDPI, vol. 13(3), pages 1-15, March.
    4. Philip R. Jansen & Mats Nagel & Kyoko Watanabe & Yongbin Wei & Jeanne E. Savage & Christiaan A. Leeuw & Martijn P. Heuvel & Sophie Sluis & Danielle Posthuma, 2020. "Genome-wide meta-analysis of brain volume identifies genomic loci and genes shared with intelligence," Nature Communications, Nature, vol. 11(1), pages 1-12, December.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Andreea O Diaconescu & Christoph Mathys & Lilian A E Weber & Jean Daunizeau & Lars Kasper & Ekaterina I Lomakina & Ernst Fehr & Klaas E Stephan, 2014. "Inferring on the Intentions of Others by Hierarchical Bayesian Learning," PLOS Computational Biology, Public Library of Science, vol. 10(9), pages 1-19, September.
    2. Amanda Rowlands & Emma C. Juergensen & Ana Paula Prescivalli & Katrina G. Salvante & Pablo A. Nepomnaschy, 2021. "Social and Biological Transgenerational Underpinnings of Adolescent Pregnancy," IJERPH, MDPI, vol. 18(22), pages 1-19, November.
    3. Alessandro Rigolon & Matthew H. E. M. Browning & Olivia McAnirlin & Hyunseo (Violet) Yoon, 2021. "Green Space and Health Equity: A Systematic Review on the Potential of Green Space to Reduce Health Disparities," IJERPH, MDPI, vol. 18(5), pages 1-27, March.
    4. Biele, Guido & Rieskamp, Jörg & Krugel, Lea K. & Heekeren, Hauke R., 2011. "The neural basis of following advice," SFB 649 Discussion Papers 2011-038, Humboldt University Berlin, Collaborative Research Center 649: Economic Risk.
    5. Nelson Gouveia, 2016. "Addressing Environmental Health Inequalities," IJERPH, MDPI, vol. 13(9), pages 1-3, August.
    6. Kari A. Weber & Wei Yang & Evan Lyons & David K. Stevenson & Amy M. Padula & Gary M. Shaw, 2021. "Greenspace, Air Pollution, Neighborhood Factors, and Preeclampsia in a Population-Based Case-Control Study in California," IJERPH, MDPI, vol. 18(10), pages 1-12, May.
    7. Manuel Belli & Paolo Rinaudo & Maria Grazia Palmerini & Elena Ruggeri & Sevastiani Antonouli & Stefania Annarita Nottola & Guido Macchiarelli, 2020. "Pre-Implantation Mouse Embryos Cultured In Vitro under Different Oxygen Concentrations Show Altered Ultrastructures," IJERPH, MDPI, vol. 17(10), pages 1-17, May.
    8. Carja, Oana & Liberman, Uri & Feldman, Marcus W., 2013. "Evolution with stochastic fitnesses: A role for recombination," Theoretical Population Biology, Elsevier, vol. 86(C), pages 29-42.
    9. Susan L. Prescott & Alan C. Logan, 2016. "Transforming Life: A Broad View of the Developmental Origins of Health and Disease Concept from an Ecological Justice Perspective," IJERPH, MDPI, vol. 13(11), pages 1-44, November.
    10. Ünsal Özdilek, 2021. "Sensing Happiness in Senseless Information," Applied Research in Quality of Life, Springer;International Society for Quality-of-Life Studies, vol. 16(5), pages 2059-2084, October.
    11. Joan A. Casey & Peter James & Lara Cushing & Bill M. Jesdale & Rachel Morello-Frosch, 2017. "Race, Ethnicity, Income Concentration and 10-Year Change in Urban Greenness in the United States," IJERPH, MDPI, vol. 14(12), pages 1-15, December.
    12. Burkhard Pleger & Christian C Ruff & Felix Blankenburg & Stefan Klöppel & Jon Driver & Raymond J Dolan, 2009. "Influence of Dopaminergically Mediated Reward on Somatosensory Decision-Making," PLOS Biology, Public Library of Science, vol. 7(7), pages 1-10, July.
    13. Samantha Gailey, 2023. "Changes in Residential Greenspace and Birth Outcomes among Siblings: Differences by Maternal Race," IJERPH, MDPI, vol. 20(18), pages 1-22, September.
    14. Kelvin C. Fong & Itai Kloog & Brent A. Coull & Petros Koutrakis & Francine Laden & Joel D. Schwartz & Peter James, 2018. "Residential Greenness and Birthweight in the State of Massachusetts, USA," IJERPH, MDPI, vol. 15(6), pages 1-15, June.
    15. Selin Akaraci & Xiaoqi Feng & Thomas Suesse & Bin Jalaludin & Thomas Astell-Burt, 2020. "A Systematic Review and Meta-Analysis of Associations between Green and Blue Spaces and Birth Outcomes," IJERPH, MDPI, vol. 17(8), pages 1-20, April.
    16. Philipp Koellinger & Matthijs Loos & Patrick Groenen & A. Thurik & Fernando Rivadeneira & Frank Rooij & André Uitterlinden & Albert Hofman, 2010. "Genome-wide association studies in economics and entrepreneurship research: promises and limitations," Small Business Economics, Springer, vol. 35(1), pages 1-18, July.
    17. Hung Chak Ho & Kevin Ka-Lun Lau & Ruby Yu & Dan Wang & Jean Woo & Timothy Chi Yui Kwok & Edward Ng, 2017. "Spatial Variability of Geriatric Depression Risk in a High-Density City: A Data-Driven Socio-Environmental Vulnerability Mapping Approach," IJERPH, MDPI, vol. 14(9), pages 1-16, August.
    18. Kathryn Abelt & Sara McLafferty, 2017. "Green Streets: Urban Green and Birth Outcomes," IJERPH, MDPI, vol. 14(7), pages 1-19, July.
    19. Carlos Olmeda-Gómez & Carlos Romá-Mateo & Maria-Antonia Ovalle-Perandones, 2019. "Overview of trends in global epigenetic research (2009–2017)," Scientometrics, Springer;Akadémiai Kiadó, vol. 119(3), pages 1545-1574, June.
    20. Hanan Shteingart & Yonatan Loewenstein, 2014. "Reinforcement Learning and Human Behavior," Discussion Paper Series dp656, The Federmann Center for the Study of Rationality, the Hebrew University, Jerusalem.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:18:y:2021:i:14:p:7429-:d:592666. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.