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Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective

Author

Listed:
  • Urbashi Basnet

    (Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA)

  • Abhijeet R. Patil

    (Computational Science Program, University of Texas at El Paso, El Paso, TX 79968, USA)

  • Aditi Kulkarni

    (Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA)

  • Sourav Roy

    (Department of Biological Sciences, University of Texas at El Paso, El Paso, TX 79968, USA
    The Border Biomedical Research Center, University of Texas at El Paso, El Paso, TX 79968, USA)

Abstract

Every year, more than a million individuals are diagnosed with colorectal cancer (CRC) across the world. Certain lifestyle and genetic factors are known to drive the high incidence and mortality rates in some groups of individuals. The presence of enormous amounts of reactive oxygen species is implicated for the on-set and carcinogenesis, and oxidant scavengers are thought to be important in CRC therapy. In this review, we focus on the ethnicity-based CRC disparities in the U.S., the negative effects of oxidative stress and apoptosis, and gene regulation in CRC carcinogenesis. We also highlight the use of antioxidants for CRC treatment, along with screening for certain regulatory genetic elements and oxidative stress indicators as potential biomarkers to determine the CRC risk and progression.

Suggested Citation

  • Urbashi Basnet & Abhijeet R. Patil & Aditi Kulkarni & Sourav Roy, 2021. "Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective," IJERPH, MDPI, vol. 18(11), pages 1-20, May.
    • Handle: RePEc:gam:jijerp:v:18:y:2021:i:11:p:5525-:d:559373
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    References listed on IDEAS

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    1. David Santamaría & Cédric Barrière & Antonio Cerqueira & Sarah Hunt & Claudine Tardy & Kathryn Newton & Javier F. Cáceres & Pierre Dubus & Marcos Malumbres & Mariano Barbacid, 2007. "Cdk1 is sufficient to drive the mammalian cell cycle," Nature, Nature, vol. 448(7155), pages 811-815, August.
    2. Daniel P. Cahill & Christoph Lengauer & Jian Yu & Gregory J. Riggins & James K. V. Willson & Sanford D. Markowitz & Kenneth W. Kinzler & Bert Vogelstein, 1998. "Mutations of mitotic checkpoint genes in human cancers," Nature, Nature, vol. 392(6673), pages 300-303, March.
    3. Dong Hoon Kang & Doo Jae Lee & Sunmi Lee & So-Young Lee & Yukyung Jun & Yerin Kim & Youngeun Kim & Ju-Seog Lee & Dae-Kee Lee & Sanghyuk Lee & Eek-Hoon Jho & Dae-Yeul Yu & Sang Won Kang, 2017. "Interaction of tankyrase and peroxiredoxin II is indispensable for the survival of colorectal cancer cells," Nature Communications, Nature, vol. 8(1), pages 1-15, December.
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