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Cdk1 is sufficient to drive the mammalian cell cycle

Author

Listed:
  • David Santamaría

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO))

  • Cédric Barrière

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
    EA2406 University of Bordeaux 2
    Present addresses: Laboratoire de Morphogenèse et Signalisation Cellulaire, UMR 144/Institut Curie, 25 rue d’Ulm, 75248 Paris Cedex 05, France (C.B.); Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Carretera de Can Ruti, Camí de les Escoles, 08916 Badalona, Barcelona, Spain (S.H.).)

  • Antonio Cerqueira

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO))

  • Sarah Hunt

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO)
    Present addresses: Laboratoire de Morphogenèse et Signalisation Cellulaire, UMR 144/Institut Curie, 25 rue d’Ulm, 75248 Paris Cedex 05, France (C.B.); Fundació Institut d’Investigació en Ciències de la Salut Germans Trias i Pujol, Carretera de Can Ruti, Camí de les Escoles, 08916 Badalona, Barcelona, Spain (S.H.).)

  • Claudine Tardy

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO))

  • Kathryn Newton

    (MRC Human Genetics Unit, Western General Hospital)

  • Javier F. Cáceres

    (MRC Human Genetics Unit, Western General Hospital)

  • Pierre Dubus

    (EA2406 University of Bordeaux 2)

  • Marcos Malumbres

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO))

  • Mariano Barbacid

    (Molecular Oncology Programme, Centro Nacional de Investigaciones Oncológicas (CNIO))

Abstract

Mouse lacking all interphase Cdks (Cdk2, Cdk3, Cdk4 and Cdk6) undergo organogenesis and develop to midgestation, and individual cells lacking all 3 kinases are able to proliferate. However, Cdk1 is shown to be absolutely essential for cell division during the first stages of embryonic development.

Suggested Citation

  • David Santamaría & Cédric Barrière & Antonio Cerqueira & Sarah Hunt & Claudine Tardy & Kathryn Newton & Javier F. Cáceres & Pierre Dubus & Marcos Malumbres & Mariano Barbacid, 2007. "Cdk1 is sufficient to drive the mammalian cell cycle," Nature, Nature, vol. 448(7155), pages 811-815, August.
    • Handle: RePEc:nat:nature:v:448:y:2007:i:7155:d:10.1038_nature06046
    DOI: 10.1038/nature06046
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    Cited by:

    1. Thomas C. J. Tan & Van Kelly & Xiaoyan Zou & David Wright & Tony Ly & Rose Zamoyska, 2022. "Translation factor eIF5a is essential for IFNγ production and cell cycle regulation in primary CD8+ T lymphocytes," Nature Communications, Nature, vol. 13(1), pages 1-16, December.
    2. Zaili Luo & Dazhuan Xin & Yunfei Liao & Kalen Berry & Sean Ogurek & Feng Zhang & Liguo Zhang & Chuntao Zhao & Rohit Rao & Xinran Dong & Hao Li & Jianzhong Yu & Yifeng Lin & Guoying Huang & Lingli Xu &, 2023. "Loss of phosphatase CTDNEP1 potentiates aggressive medulloblastoma by triggering MYC amplification and genomic instability," Nature Communications, Nature, vol. 14(1), pages 1-19, December.
    3. Urbashi Basnet & Abhijeet R. Patil & Aditi Kulkarni & Sourav Roy, 2021. "Role of Stress-Survival Pathways and Transcriptomic Alterations in Progression of Colorectal Cancer: A Health Disparities Perspective," IJERPH, MDPI, vol. 18(11), pages 1-20, May.

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