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Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden

Author

Listed:
  • Yumjirmaa Mandakh

    (Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden)

  • Ralf Rittner

    (Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden)

  • Erin Flanagan

    (Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden)

  • Anna Oudin

    (Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden)

  • Christina Isaxon

    (Department of Ergonomics and Aerosol Technology, Lund University, Sölvegatan 26, Box 118, 22100 Lund, Sweden)

  • Mary Familari

    (School of BioSciences, University of Melbourne, Parkville, Melbourne 3010, Australia)

  • Stefan Rocco Hansson

    (Division of Obstetrics and Gynecology, Department of Clinical Sciences, Lund University, Klinikgatan 12, 22185 Lund, Sweden)

  • Ebba Malmqvist

    (Division of Occupational and Environmental Medicine, Department of Laboratory Medicine, Lund University, Scheelevägen 8, Building 402A, 22381 Lund, Sweden)

Abstract

The aim of this study was to investigate the risk of developing preeclampsia (PE) associated with gestational exposure to ambient air pollutants in southern Sweden, a low-exposure area. We used a cohort of 43,688 singleton pregnancies and monthly mean exposure levels of black carbon (BC), local and total particulate matter (PM 2.5 and PM 10 ), and NO X at the maternal residential address estimated by Gaussian dispersion modeling from 2000 to 2009. Analyses were conducted using binary logistic regression. A subtype analysis for small-for-gestational age (SGA) was performed. All analyses were adjusted for obstetrical risk factors and socioeconomic predictors. There were 1286 (2.9%) PE cases in the analysis. An adjusted odds ratio (AOR) of 1.35 with a 95% confidence interval (CI) of 1.11–1.63 was found when comparing the lowest quartile of BC exposure to the highest quartile in the third trimester The AOR for PE associated with each 5 µg/m 3 increase in locally emitted PM 2.5 was 2.74 (95% CI: 1.68, 4.47) in the entire pregnancy. Similar patterns were observed for each 5 µg/m 3 increment in locally emitted PM 10 . In pregnancies complicated by PE with SGA, the corresponding AOR for linear increases in BC was 3.48 (95% CI: 1.67, 7.27). In this low-level setting, maternal exposure to ambient air pollution during gestation was associated with the risk of developing PE. The associations seemed more pronounced in pregnancies with SGA complications, a finding that should be investigated further.

Suggested Citation

  • Yumjirmaa Mandakh & Ralf Rittner & Erin Flanagan & Anna Oudin & Christina Isaxon & Mary Familari & Stefan Rocco Hansson & Ebba Malmqvist, 2020. "Maternal Exposure to Ambient Air Pollution and Risk of Preeclampsia: A Population-Based Cohort Study in Scania, Sweden," IJERPH, MDPI, vol. 17(5), pages 1-16, March.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:5:p:1744-:d:329674
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    References listed on IDEAS

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    1. Amelia K. Wesselink & Jenny L. Carwile & María Patricia Fabian & Michael R. Winter & Lindsey J. Butler & Shruthi Mahalingaiah & Ann Aschengrau, 2017. "Residential Proximity to Roadways and Ischemic Placental Disease in a Cape Cod Family Health Study," IJERPH, MDPI, vol. 14(7), pages 1-14, June.
    2. Ya-Ling Yang & Hsiao-Ling Yang & S. Pamela K. Shiao, 2018. "Meta-Prediction of MTHFR Gene Polymorphisms and Air Pollution on the Risk of Hypertensive Disorders in Pregnancy Worldwide," IJERPH, MDPI, vol. 15(2), pages 1-14, February.
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    Cited by:

    1. Wenzheng Zhou & Xin Ming & Yunping Yang & Yaqiong Hu & Ziyi He & Hongyan Chen & Yannan Li & Xiaojun Zhou & Ping Yin, 2022. "Association between Maternal Exposure to Ambient Air Pollution and the Risk of Preterm Birth: A Birth Cohort Study in Chongqing, China, 2015–2020," IJERPH, MDPI, vol. 19(4), pages 1-15, February.

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