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Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies

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  • Cong Li

    (Hubei Provincial Center for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan 430079, Hubei, China
    Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China)

  • Chunhong Wang

    (Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China)

  • Jun Yu

    (Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China)

  • Yongsheng Fan

    (Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China)

  • Duanya Liu

    (Department of Preventive Medicine, School of Health Sciences, Wuhan University, Donghu Road 115, Wuhan 430071, Hubei, China)

  • Wenshan Zhou

    (Hubei Provincial Center for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan 430079, Hubei, China)

  • Tingming Shi

    (Hubei Provincial Center for Disease Control and Prevention, 6 Zhuodaoquan North Road, Wuhan 430079, Hubei, China)

Abstract

Epidemiological studies on residential radon exposure and the risk of histological types of lung cancer have yielded inconsistent results. We conducted a meta-analysis on this topic and updated previous related meta-analyses. We searched the databases of Cochrane Library, Embase, PubMed, Web of Science and Chinese National Knowledge Infrastructure for papers published up to 13 November 2018. The pooled odds ratio (OR) and 95% confidence interval (CI) were calculated using fixed and random effects models. Subgroup and dose‒response analyses were also conducted. This study was registered with PROSPERO (No. CRD42019127761). A total of 28 studies, which included 13,748 lung cancer cases and 23,112 controls, were used for this meta-analysis. The pooled OR indicated that the highest residential radon exposure was significantly associated with an increased risk of lung cancer (OR = 1.48, 95% CI = 1.26–1.73). All histological types of lung cancer were associated with residential radon. Strongest association with small-cell lung carcinoma (OR = 2.03, 95% CI = 1.52–2.71) was found, followed by adenocarcinoma (OR = 1.58, 95% CI = 1.31–1.91), other histological types (OR = 1.54, 95% CI = 1.11–2.15) and squamous cell carcinoma (OR = 1.43, 95% CI = 1.18–1.74). With increasing residential radon levels per 100 Bq/m 3 , the risk of lung cancer, small-cell lung carcinoma and adenocarcinoma increased by 11%, 19% and 13%, respectively. This meta-analysis provides new evidence for a potential relationship between residential radon and all histological types of lung cancer.

Suggested Citation

  • Cong Li & Chunhong Wang & Jun Yu & Yongsheng Fan & Duanya Liu & Wenshan Zhou & Tingming Shi, 2020. "Residential Radon and Histological Types of Lung Cancer: A Meta-Analysis of Case‒Control Studies," IJERPH, MDPI, vol. 17(4), pages 1-16, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1457-:d:324587
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    References listed on IDEAS

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    1. Alavanja, M.C.R. & Lubin, J.H. & Mahaffey, J.A. & Brownson, R.C., 1999. "Residential radon exposure and risk of lung cancer in Missouri," American Journal of Public Health, American Public Health Association, vol. 89(7), pages 1042-1048.
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    Cited by:

    1. Anna Grzywa-Celińska & Izabela Chmielewska & Adam Krusiński & Krzysztof Kozak & Jadwiga Mazur & Dominik Grządziel & Katarzyna Dos Santos Szewczyk & Janusz Milanowski, 2022. "Residential Radon Exposure in Patients with Advanced Lung Cancer in Lublin Region, Poland," IJERPH, MDPI, vol. 19(7), pages 1-9, April.
    2. Le Thi Nhu Ngoc & Duckshin Park & Young-Chul Lee, 2022. "Human Health Impacts of Residential Radon Exposure: Updated Systematic Review and Meta-Analysis of Case–Control Studies," IJERPH, MDPI, vol. 20(1), pages 1-19, December.
    3. Ignacio Hernández-García & Antonio-Javier Chamorro & Hugo Guillermo Ternavasio-de la Vega & Cristina Carbonell & Miguel Marcos & José-Antonio Mirón-Canelo, 2020. "Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies," IJERPH, MDPI, vol. 17(21), pages 1-16, October.
    4. Norie Kanzaki & Akihiro Sakoda & Takahiro Kataoka & Lue Sun & Hiroshi Tanaka & Iwao Ohtsu & Kiyonori Yamaoka, 2022. "Changes in Sulfur Metabolism in Mouse Brains following Radon Inhalation," IJERPH, MDPI, vol. 19(17), pages 1-14, August.

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