Author
Listed:
- Ignacio Hernández-García
(Department of Preventive Medicine and Public Health, Lozano Blesa University Clinical Hospital of Zaragoza, Calle San Juan Bosco 15, 50009 Zaragoza, Spain)
- Antonio-Javier Chamorro
(Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
Department of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain
Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain)
- Hugo Guillermo Ternavasio-de la Vega
(Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
Department of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain
Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain)
- Cristina Carbonell
(Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
Department of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain
Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain)
- Miguel Marcos
(Department of Medicine, University of Salamanca, 37007 Salamanca, Spain
Department of Internal Medicine, University Hospital of Salamanca, 37007 Salamanca, Spain
Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain
These two authors are both senior authors of this article.)
- José-Antonio Mirón-Canelo
(Institute of Biomedical Research of Salamanca (IBSAL), 37007 Salamanca, Spain
Department of Epidemiology, University of Salamanca, 37007 Salamanca, Spain
These two authors are both senior authors of this article.)
Abstract
Autistic spectrum disorder (ASD) is a complex neurodevelopmental disability with a genetic basis, and several studies have suggested a potential role of the reelin gene (RELN) in ASD susceptibility. Accordingly, genetic association studies have explored this potential association, but the results have been controversial thus far. For this reason, we assessed the association of four genetic variants of RELN (the 5′UTR CGG triplet repeat and polymorphisms rs736707, rs362691, and rs2229864) with ASD by means of a systematic review and meta-analysis. We retrieved studies comparing the distribution of the above-mentioned genetic variants between ASD patients and healthy controls. A meta-analysis was conducted using a random effects model, and calculations of the odds ratios (ORs) and confidence intervals (CIs) were performed. A sensitivity analysis and tests to determine the heterogeneity of the results were also performed. Eleven previous studies fulfilled the inclusion criteria and analyzed the association of the above-mentioned genetic variants and ASD. We did not find any significant association between the allele or genotype frequencies of the analyzed polymorphisms and ASD, and large heterogeneity was found for the rs736707 polymorphism. Moreover, no significant differences were found between the 5′UTR triplet repeat and this disorder. In light of current evidence, no single genetic variant within this gene is clearly associated with the development of ASD, and ethnic differences may explain part of the observed heterogeneity. Larger studies among different ethnic groups are needed to establish the role of specific genetic variants within RELN in the etiology of this disorder.
Suggested Citation
Ignacio Hernández-García & Antonio-Javier Chamorro & Hugo Guillermo Ternavasio-de la Vega & Cristina Carbonell & Miguel Marcos & José-Antonio Mirón-Canelo, 2020.
"Association of Allelic Variants of the Reelin Gene with Autistic Spectrum Disorder: A Systematic Review and Meta-Analysis of Candidate Gene Association Studies,"
IJERPH, MDPI, vol. 17(21), pages 1-16, October.
Handle:
RePEc:gam:jijerp:v:17:y:2020:i:21:p:8010-:d:437768
Download full text from publisher
Most related items
These are the items that most often cite the same works as this one and are cited by the same works as this one.
- Le Thi Nhu Ngoc & Duckshin Park & Young-Chul Lee, 2022.
"Human Health Impacts of Residential Radon Exposure: Updated Systematic Review and Meta-Analysis of Case–Control Studies,"
IJERPH, MDPI, vol. 20(1), pages 1-19, December.
- Norie Kanzaki & Akihiro Sakoda & Takahiro Kataoka & Lue Sun & Hiroshi Tanaka & Iwao Ohtsu & Kiyonori Yamaoka, 2022.
"Changes in Sulfur Metabolism in Mouse Brains following Radon Inhalation,"
IJERPH, MDPI, vol. 19(17), pages 1-14, August.
- Anna Grzywa-Celińska & Izabela Chmielewska & Adam Krusiński & Krzysztof Kozak & Jadwiga Mazur & Dominik Grządziel & Katarzyna Dos Santos Szewczyk & Janusz Milanowski, 2022.
"Residential Radon Exposure in Patients with Advanced Lung Cancer in Lublin Region, Poland,"
IJERPH, MDPI, vol. 19(7), pages 1-9, April.
Corrections
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:21:p:8010-:d:437768. See general information about how to correct material in RePEc.
If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.
If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .
If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.
For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .
Please note that corrections may take a couple of weeks to filter through
the various RePEc services.