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Effect of Polycyclic Aromatic Hydrocarbons on Development of the Ascidian Ciona intestinalis Type A

Author

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  • Toshio Sekiguchi

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan)

  • Hiroshi Akitaya

    (Department of Animal Bioscience, Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan)

  • Satoshi Nakayama

    (Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan)

  • Takashi Yazawa

    (Department of Biochemistry, Asahikawa Medical University, Hokkaido 078-8510, Japan)

  • Michio Ogasawara

    (Department of Biology, Graduate School of Science, Chiba University, 1-33 Yayoi-cho, Inage-ku, Chiba 263-8522, Japan)

  • Nobuo Suzuki

    (Noto Marine Laboratory, Institute of Nature and Environmental Technology, Division of Marine Environmental Studies, Kanazawa University, Noto-cho, Ishikawa 927-0553, Japan)

  • Kazuichi Hayakawa

    (Low Level Radioactivity Laboratory, Institute of Nature and Environmental Technology, Kanazawa University, Nomi City, Ishikawa 923-1224, Japan)

  • Shuichi Wada

    (Department of Animal Bioscience, Faculty of Bioscience, Nagahama Institute of Bio-Science and Technology, Nagahama, Shiga 526-0829, Japan)

Abstract

Polycyclic aromatic hydrocarbons (PAHs) are pollutants that exert harmful effects on marine invertebrates; however, the molecular mechanism underlying PAH action remains unclear. We investigated the effect of PAHs on the ascidian Ciona intestinalis type A ( Ciona robusta ). First, the influence of PAHs on early Ciona development was evaluated. PAHs such as dibenzothiophene, fluorene, and phenanthrene resulted in formation of abnormal larvae. PAH treatment of swimming larva induced malformation in the form of tail regression. Additionally, we observed the Ciona aryl hydrocarbon receptor ( Ci-AhR ) mRNA expression in swimming larva, mid body axis rotation, and early juvenile stages. The time correlation between PAH action and AhR mRNA expression suggested that Ci-AhR could be associated with PAH metabolism. Lastly, we analyzed Ci-AhR mRNA localization in Ciona juveniles. Ci-AhR mRNA was localized in the digestive tract, dorsal tubercle, ganglion, and papillae of the branchial sac, suggesting that Ci-AhR is a candidate for an environmental pollutant sensor and performs a neural function. Our results provide basic knowledge on the biological function of Ci-AhR and PAH activity in marine invertebrates.

Suggested Citation

  • Toshio Sekiguchi & Hiroshi Akitaya & Satoshi Nakayama & Takashi Yazawa & Michio Ogasawara & Nobuo Suzuki & Kazuichi Hayakawa & Shuichi Wada, 2020. "Effect of Polycyclic Aromatic Hydrocarbons on Development of the Ascidian Ciona intestinalis Type A," IJERPH, MDPI, vol. 17(4), pages 1-11, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1340-:d:322546
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    References listed on IDEAS

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    1. Chen Cao & Laurence A. Lemaire & Wei Wang & Peter H. Yoon & Yoolim A. Choi & Lance R. Parsons & John C. Matese & Wei Wang & Michael Levine & Kai Chen, 2019. "Comprehensive single-cell transcriptome lineages of a proto-vertebrate," Nature, Nature, vol. 571(7765), pages 349-354, July.
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    Cited by:

    1. Xuanbo Wang & Hang Ren & Xishan Li & Huishu Chen & Zhonglei Ju & Deqi Xiong, 2021. "Sex-Specific Differences in the Toxic Effects of Heavy Fuel Oil on Sea Urchin ( Strongylocentrotus intermedius )," IJERPH, MDPI, vol. 18(2), pages 1-9, January.

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