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Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)

Author

Listed:
  • Alessandra Panico

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
    These authors contributed equally to this work.)

  • Tiziana Grassi

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy
    These authors contributed equally to this work.)

  • Francesco Bagordo

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

  • Adele Idolo

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

  • Francesca Serio

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

  • Maria Rosaria Tumolo

    (Institute for Research on Population and Social Policies, National Research Council (IRPPS-CNR), 72100 Brindisi, Italy
    Institute of Clinical Physiology (CNR-IFC), 73100 Lecce, Italy)

  • Mattia De Giorgi

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

  • Marcello Guido

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

  • Maria Tutino

    (Regional Agency for Environmental Protection (ARPA Puglia), 70126 Bari, Italy)

  • Antonella De Donno

    (Department of Biological and Environmental Sciences and Technologies, University of Salento, 73100 Lecce, Italy)

Abstract

Micronuclei (MN) are biomarkers of early biological effect often used for detecting DNA damage in human population exposed to genotoxic agents. The aim of this study was to evaluate the frequency of MN in exfoliated buccal cells of children living in an industrialized (impacted) area compared with that found in children living in a control area without significant anthropogenic impacts. A total of 462 6–8-year-old children (206 in the impacted area, 256 in the control area) attending primary school were enrolled. A questionnaire was administered to the parents of the recruited children to obtain information about personal data, lifestyles, and food habits of their children. Atmospheric particulate fractions were collected near the involved schools to assess the level of environmental exposure of the children. The presence of MN was highlighted in 68.4% of children living in the impacted area with a mean MN frequency of 0.66‰ ± 0.61‰. MN positivity and frequency were significantly lower in the control area (37.1% and 0.27‰ ± 0.43‰, respectively). The frequency of MN was positively associated with quasi-ultrafine particulate matter (PM 0.5 ), traffic near the home, and consuming barbecued food; while adherence to the Mediterranean diet and practicing sport were negatively associated.

Suggested Citation

  • Alessandra Panico & Tiziana Grassi & Francesco Bagordo & Adele Idolo & Francesca Serio & Maria Rosaria Tumolo & Mattia De Giorgi & Marcello Guido & Maria Tutino & Antonella De Donno, 2020. "Micronucleus Frequency in Exfoliated Buccal Cells of Children Living in an Industrialized Area of Apulia (Italy)," IJERPH, MDPI, vol. 17(4), pages 1-18, February.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:4:p:1208-:d:320309
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    References listed on IDEAS

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    1. Tiziana Grassi & Antonella De Donno & Francesco Bagordo & Francesca Serio & Prisco Piscitelli & Elisabetta Ceretti & Claudia Zani & Gaia C. V. Viola & Milena Villarini & Massimo Moretti & Sara Levorat, 2016. "Socio-Economic and Environmental Factors Associated with Overweight and Obesity in Children Aged 6–8 Years Living in Five Italian Cities (the MAPEC_LIFE Cohort)," IJERPH, MDPI, vol. 13(10), pages 1-11, October.
    2. Adele Idolo & Tiziana Grassi & Francesco Bagordo & Alessandra Panico & Mattia De Giorgi & Francesca Serio & Marcello Guido & Prisco Piscitelli & Giovanni De Filippis & Annamaria Raho & Antonella De Do, 2018. "Micronuclei in Exfoliated Buccal Cells of Children Living in a Cluster Area of Salento (Southern Italy) with a High Incidence of Lung Cancer: The IMP.AIR Study," IJERPH, MDPI, vol. 15(8), pages 1-15, August.
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    1. Susanne Kobel & Jens Dreyhaupt & Olivia Wartha & Sarah Kettner & Belinda Hoffmann & Jürgen M. Steinacker, 2020. "Intervention Effects of the Health Promotion Programme “Join the Healthy Boat” on Objectively Assessed Sedentary Time in Primary School Children in Germany," IJERPH, MDPI, vol. 17(23), pages 1-14, December.
    2. Fabrizio Minichilli & Francesca Gorini & Giovanni De Filippis & Elisa Bustaffa & Anna Maria Raho & Anna Melcarne & Fabrizio Quarta & Giuseppe Maggiore & Adele Idolo & Francesca Serio & Tiziana Grassi , 2022. "Risk Factors for Lung Cancer in the Province of Lecce: Results from the PROTOS Case–Control Study in Salento (Southern Italy)," IJERPH, MDPI, vol. 19(14), pages 1-22, July.
    3. Giovanni Imbriani & Alessandra Panico & Tiziana Grassi & Adele Idolo & Francesca Serio & Francesco Bagordo & Giovanni De Filippis & Donato De Giorgi & Gianfranco Antonucci & Prisco Piscitelli & Manuel, 2021. "Early-Life Exposure to Environmental Air Pollution and Autism Spectrum Disorder: A Review of Available Evidence," IJERPH, MDPI, vol. 18(3), pages 1-24, January.
    4. Mattia Acito & Cristina Fatigoni & Milena Villarini & Massimo Moretti, 2022. "Cytogenetic Effects in Children Exposed to Air Pollutants: A Systematic Review and Meta-Analysis," IJERPH, MDPI, vol. 19(11), pages 1-17, May.

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