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Relationship between Bell’s Palsy and Previous Statin Use: A Case/Non-Case Study

Author

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  • So Young Kim

    (Department of Otorhinolaryngology-Head & Neck Surgery, CHA Bundang Medical Center, CHA University, Seongnam 13496, Korea)

  • Jee Hye Wee

    (Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Anyang 14068, Korea)

  • Chanyang Min

    (Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea
    Graduate School of Public Health, Seoul National University, Seoul 08826, Korea)

  • Dae-Myoung Yoo

    (Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea)

  • Hyo Geun Choi

    (Department of Otorhinolaryngology-Head & Neck Surgery, Hallym University College of Medicine, 22, Gwanpyeong-ro 170beon-gil, Dongan-gu, Anyang-si, Gyeonggi-do, Anyang 14068, Korea
    Hallym Data Science Laboratory, Hallym University College of Medicine, Anyang 14068, Korea)

Abstract

We intended to determine the relationship between previous statin use and Bell’s palsy in a large study population receiving statins for the past 2 years. The Korean National Health Insurance Service—Health Screening Cohort data from 2002 to 2015 were collected. Participants with Bell’s palsy ( n = 3203) were matched with participants without Bell’s palsy ( n = 12,812). The number of days of previous statin use for 2 years before the onset of Bell’s palsy was analyzed using conditional logistic regression. Subgroups of age, sex, obesity, smoking, alcohol consumption, total cholesterol, and blood pressure were analyzed for any association between Bell’s palsy and prior statin use. The Bell’s palsy group reported greater statin use than the non-Bell’s palsy group (84.6 (standard deviation, SD = 201.7) vs. 74.4(SD = 189.4), p = 0.009). Previous statin use was associated with Bell’s palsy in the crude model (95% confidence intervals = 1.03–1.19, p = 0.006). However, this relationship disappeared when the possible covariates were adjusted for in model 2. All subgroups showed no increased odds for Bell’s palsy in previous statin users. We did not find an association between Bell’s palsy and previous statin use in this Korean population aged ≥40 years.

Suggested Citation

  • So Young Kim & Jee Hye Wee & Chanyang Min & Dae-Myoung Yoo & Hyo Geun Choi, 2020. "Relationship between Bell’s Palsy and Previous Statin Use: A Case/Non-Case Study," IJERPH, MDPI, vol. 17(22), pages 1-10, November.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:22:p:8408-:d:444648
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    References listed on IDEAS

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    1. Tsung-Hsing Hung & Chih-Chun Tsai & Hsing-Feng Lee, 2019. "Statin use in cirrhotic patients with infectious diseases: A population-based study," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-10, April.
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    Cited by:

    1. So-Young Kim & Dae-Myoung Yoo & Chanyang Min & Hyo-Geun Choi, 2021. "Association between Osteoporosis and Low Hemoglobin Levels: A Nested Case–Control Study Using a National Health Screening Cohort," IJERPH, MDPI, vol. 18(16), pages 1-9, August.
    2. So Young Kim & Dae Myoung Yoo & Chanyang Min & Hyo Geun Choi, 2021. "Association between Statin Use and Meniere’s Disease: Results from a National Health Screening Cohort," IJERPH, MDPI, vol. 18(16), pages 1-10, August.

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