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Statin use in cirrhotic patients with infectious diseases: A population-based study

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  • Tsung-Hsing Hung
  • Chih-Chun Tsai
  • Hsing-Feng Lee

Abstract

Background: Recent studies have shown benefits of statins in patients with liver cirrhosis. However, it is still unknown if statins have a beneficial effect on the mortality of cirrhotic patients with bacterial infections. Methods: The Taiwan National Health Insurance Database was searched, and 816 cirrhotic patients receiving statins with bacterial infections hospitalized between January 1, 2010 and December 31, 2013 were included in the study. A one-to-four propensity score matching was performed to select a comparison group based on age, sex, and comorbid disorders. Results: The overall 30-day mortalities in statin and non-statin group were 5.3% and 9.8%, respectively (P = 0.001). After Cox regression modeling adjusting for age, sex, and comorbid disorders, the hazard ratio (HR) of statin use on 30-day mortality was 0.52 (95% confidence interval [CI]: 0.38–0.72, P

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  • Tsung-Hsing Hung & Chih-Chun Tsai & Hsing-Feng Lee, 2019. "Statin use in cirrhotic patients with infectious diseases: A population-based study," PLOS ONE, Public Library of Science, vol. 14(4), pages 1-10, April.
    • Handle: RePEc:plo:pone00:0215839
    DOI: 10.1371/journal.pone.0215839
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    References listed on IDEAS

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    1. Shao-Peng Lin & You-Ming Long & Xiao-Hui Chen, 2015. "The Effects of Statins on Infections after Stroke or Transient Ischemic Attack: A Meta-Analysis," PLOS ONE, Public Library of Science, vol. 10(7), pages 1-10, July.
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    Cited by:

    1. So Young Kim & Jee Hye Wee & Chanyang Min & Dae-Myoung Yoo & Hyo Geun Choi, 2020. "Relationship between Bell’s Palsy and Previous Statin Use: A Case/Non-Case Study," IJERPH, MDPI, vol. 17(22), pages 1-10, November.

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