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Serum Uric Acid in Roma and Non-Roma—Its Correlation with Metabolic Syndrome and Other Variables

Author

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  • Jana Petrikova

    (1st Department of Internal Medicine, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia
    Louis Pasteur University Hospital, 040 01 Kosice, Slovakia)

  • Martin Janicko

    (1st Department of Internal Medicine, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia
    Louis Pasteur University Hospital, 040 01 Kosice, Slovakia)

  • Jan Fedacko

    (Department of Gerontology and Geriatrics, Faculty of Medicine, PJ Safarik University, 040 01 Kosice, Slovakia
    Air Force Military Hospital, 040 86 Kosice, Slovakia)

  • Sylvia Drazilova

    (Department of Internal Medicine, Poprad Hospital, 058 01 Poprad, Slovakia)

  • Andrea Madarasova Geckova

    (Department of Health Psychology, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia)

  • Maria Marekova

    (Department of Medical and Clinical Biochemistry, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia)

  • Daniel Pella

    (1st Department of Internal Medicine, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia
    Louis Pasteur University Hospital, 040 01 Kosice, Slovakia)

  • Peter Jarcuska

    (1st Department of Internal Medicine, Faculty of Medicine, PJ Safarik University, 040 11 Kosice, Slovakia
    Louis Pasteur University Hospital, 040 01 Kosice, Slovakia)

Abstract

Background : The Roma population is one of the major marginalized groups in Europe, having higher incidence of all spectrums of disease and a shorter life expectancy. Yet, the reasons for higher morbidity and its exact prevalence were not properly studied. Objectives : The objective of our study was to compare the frequency of metabolic syndrome (MetS) in Roma people to the non-Roma population in Slovakia, and to compare levels of uric acid and its correlation with components of metabolic syndrome. Methods : A group of 452 Roma people aged 18–55 years, was compared to a control group of 403 non-Roma people. The data were obtained by questionnaire, anthropometric measures, and analyzed blood and urine samples Results : The prevalence of MetS was significantly higher among Roma participants (131; 29.6%) compared with non-Roma participants (80; 20.1%), p = 0.001. Roma people significantly more often fulfilled obesity and low high-density lipoprotein (HDL) criteria of MetS (257, 58.9% vs. 180, 45.8%, p < 0.0001, and 312, 70.0% vs. 140, 34.9%, p < 0.0001). There was no difference in the triacylglycerols (TG), glycemia or blood pressure (BP) criteria of MetS. The Roma also presented with greater levels of high sensitivity C-reactive protein (hs-CRP). Baseline levels of uric acid (UA) among the Roma population were significantly lower compared with the majority population (226.54 ± 79.8 vs. 259.11 ± 84.53) ( p < 0.001). The levels of UA significantly correlated with fulfilled criteria of MetS. Univariate regression showed that UA is a significant predictor of MetS in the whole cohort (unadjusted odds ratio (OR) 1.005; 95% CI 1.004–1.007; p < 0.0001) also after the adjustment for age, sex, and ethnicity (adjusted OR 1.008; 95% CI 1.005–1.010; p < 0.0001). Conclusions : We were able to show that prevalence of MetS among the Roma is higher than in the majority population. Moreover, the uric acid levels are significantly lower in the Roma group as well as when it comes to a cohort with MetS. Levels of UA, besides others, depend on ethnicity, age, and sex.

Suggested Citation

  • Jana Petrikova & Martin Janicko & Jan Fedacko & Sylvia Drazilova & Andrea Madarasova Geckova & Maria Marekova & Daniel Pella & Peter Jarcuska, 2018. "Serum Uric Acid in Roma and Non-Roma—Its Correlation with Metabolic Syndrome and Other Variables," IJERPH, MDPI, vol. 15(7), pages 1-15, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1412-:d:156249
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    References listed on IDEAS

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    1. Koupilová, Ilona & Epstein, Helen & Holcík, Jan & Hajioff, Steve & McKee, Martin, 2001. "Health needs of the Roma population in the Czech and Slovak Republics," Social Science & Medicine, Elsevier, vol. 53(9), pages 1191-1204, November.
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    1. Zelmira Macejova & Pavol Kristian & Martin Janicko & Monika Halanova & Sylvia Drazilova & Daniela Antolova & Maria Marekova & Daniel Pella & Andrea Madarasova-Geckova & Peter Jarcuska & HepaMeta Team, 2020. "The Roma Population Living in Segregated Settlements in Eastern Slovakia Has a Higher Prevalence of Metabolic Syndrome, Kidney Disease, Viral Hepatitis B and E, and Some Parasitic Diseases Compared to," IJERPH, MDPI, vol. 17(9), pages 1-12, April.
    2. Maria Pallayova & Marek Brenisin & Alina Putrya & Martin Vrsko & Sylvia Drazilova & Martin Janicko & Maria Marekova & Daniel Pella & Andrea Madarasova Geckova & Peter Urdzik & Peter Jarcuska & HepaMet, 2020. "Roma Ethnicity and Sex-Specific Associations of Serum Uric Acid with Cardiometabolic and Hepatorenal Health Factors in Eastern Slovakian Population: The HepaMeta Study," IJERPH, MDPI, vol. 17(20), pages 1-15, October.
    3. Michal Kozubik & Jitse P. van Dijk & Daniela Filakovska Bobakova, 2019. "Aspects of Illness and Death among Roma—Have They Changed after More than Two Hundred Years?," IJERPH, MDPI, vol. 16(23), pages 1-11, November.

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