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The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals

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  • Javier Labad

    (Consorci Sanitari del Maresme, 08340 Mataró, Spain
    Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
    Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain)

  • Neus Salvat-Pujol

    (Department of Mental Health, Parc Taulí Hospital Universitari, Universitat Autònoma de Barcelona, 08208 Sabadell, Spain
    Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain)

  • Antonio Armario

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Ángel Cabezas

    (Hospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, 43206 Reus, Spain)

  • Aida de Arriba-Arnau

    (Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain)

  • Roser Nadal

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Institut de Neurociències, Universitat Autònoma de Barcelona, 08193 Bellaterra, Spain)

  • Lourdes Martorell

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Hospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, 43206 Reus, Spain)

  • Mikel Urretavizcaya

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain
    Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, 08907 L’Hospitalet de Llobregat, Spain)

  • José Antonio Monreal

    (Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
    Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Mental Health, Parc Taulí Hospital Universitari, Universitat Autònoma de Barcelona, 08208 Sabadell, Spain)

  • José Manuel Crespo

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain
    Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, 08907 L’Hospitalet de Llobregat, Spain)

  • Elisabet Vilella

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Hospital Universitari Institut Pere Mata, Institut d’Investigació Sanitària Pere Virgili (IISPV), Universitat Rovira i Virgili, 43206 Reus, Spain)

  • Diego José Palao

    (Institut d’Investigació i Innovació Parc Taulí (I3PT), 08208 Sabadell, Spain
    Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Mental Health, Parc Taulí Hospital Universitari, Universitat Autònoma de Barcelona, 08208 Sabadell, Spain)

  • José Manuel Menchón

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain
    Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, 08907 L’Hospitalet de Llobregat, Spain)

  • Virginia Soria

    (Centro de Investigación Biomédica en Red de Salud Mental (CIBERSAM), Carlos III Health Institute, 28029 Madrid, Spain
    Department of Psychiatry, Bellvitge University Hospital, 08907 L’Hospitalet de Llobregat, Spain
    Neurosciences Group—Psychiatry and Mental Health, Biomedical Research Institute (IDIBELL), 08908 L’Hospitalet de Llobregat, Spain
    Department of Clinical Sciences, School of Medicine, Universitat de Barcelona, 08907 L’Hospitalet de Llobregat, Spain)

Abstract

Sleep plays a crucial role in cognitive processes. Sleep and wake memory consolidation seem to be regulated by glucocorticoids, pointing out the potential role of the hypothalamic-pituitary-adrenal (HPA) axis in the relationship between sleep quality and cognitive abilities. Trait anxiety is another factor that is likely to moderate the relationship between sleep and cognition, because poorer sleep quality and subtle HPA axis abnormalities have been reported in people with high trait anxiety. The current study aimed to explore whether HPA axis activity or trait anxiety moderate the relationship between sleep quality and cognitive abilities in healthy individuals. We studied 203 healthy individuals. We measured verbal and visual memory, working memory, processing speed, attention and executive function. Sleep quality was assessed with the Pittsburgh Sleep Quality Index. Trait anxiety was assessed with the State-Trait Anxiety Inventory. HPA axis measures included the cortisol awakening response (CAR), diurnal cortisol slope and cortisol levels during the day. Multiple linear regression analyses explored the relationship between sleep quality and cognition and tested potential moderating effects by HPA axis measures and trait anxiety. Poor sleep quality was associated with poorer performance in memory, processing speed and executive function tasks. In people with poorer sleep quality, a blunted CAR was associated with poorer verbal and visual memory and executive functions, and higher cortisol levels during the day were associated with poorer processing speed. Trait anxiety was a moderator of visual memory and executive functioning. These results suggest that subtle abnormalities in the HPA axis and higher trait anxiety contribute to the relationship between lower sleep quality and poorer cognitive functioning in healthy individuals.

Suggested Citation

  • Javier Labad & Neus Salvat-Pujol & Antonio Armario & Ángel Cabezas & Aida de Arriba-Arnau & Roser Nadal & Lourdes Martorell & Mikel Urretavizcaya & José Antonio Monreal & José Manuel Crespo & Elisabet, 2020. "The Role of Sleep Quality, Trait Anxiety and Hypothalamic-Pituitary-Adrenal Axis Measures in Cognitive Abilities of Healthy Individuals," IJERPH, MDPI, vol. 17(20), pages 1-18, October.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:20:p:7600-:d:431131
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    References listed on IDEAS

    as
    1. Robert D. Nebes & Daniel J. Buysse & Edythe M. Halligan & Patricia R. Houck & Timothy H. Monk, 2009. "Self-Reported Sleep Quality Predicts Poor Cognitive Performance in Healthy Older Adults," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 64(2), pages 180-187.
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