IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i19p7239-d423561.html
   My bibliography  Save this article

Addition of Probiotics to Anti-Obesity Therapy by Percutaneous Electrical Stimulation of Dermatome T6. A Pilot Study

Author

Listed:
  • Oscar Lorenzo

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain
    Spanish Biomedical Research Centre on Diabetes and Associated Metabolic Disorders (CIBERDEM) Network, 28040 Madrid, Spain)

  • Marta Crespo-Yanguas

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Tianyu Hang

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Jairo Lumpuy-Castillo

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Artur M. Hernández

    (Department of Sport Sciences, Universidad Europea de Madrid, 28670 Villaviciosa de Odón-Madrid, Spain)

  • Carolina Llavero

    (Obesity Unit, Clinica Garcilaso, 28010 Madrid, Spain)

  • MLuisa García-Alonso

    (Laboratory of Diabetes and Vascular Pathology, Instituto de Investigaciones Sanitarias-Fundación Jiménez Díaz, Universidad Autónoma, 28040 Madrid, Spain)

  • Jaime Ruiz-Tovar

    (Obesity Unit, Clinica Garcilaso, 28010 Madrid, Spain
    Department of Health Sciences, Universidad Rey Juan Carlos, 28933 Mostoles-Madrid, Spain)

Abstract

Obesity is becoming a pandemic and percutaneous electrical stimulation (PENS) of dermatome T6 has been demonstrated to reduce stomach motility and appetite, allowing greater weight loss than isolated hypocaloric diets. However, modulation of intestinal microbiota could improve this effect and control cardiovascular risk factors. Our objective was to test whether addition of probiotics could improve weight loss and cardiovascular risk factors in obese subjects after PENS and a hypocaloric diet. A pilot prospective study was performed in patients ( n = 20) with a body mass index (BMI) > 30 kg/m 2 . Half of them underwent ten weeks of PENS in conjunction with a hypocaloric diet (PENS-Diet), and the other half was treated with a PENS-Diet plus multistrain probiotics ( L. plantarum LP115 , B. brevis B3 , and L. acidophilus LA14 ) administration. Fecal samples were obtained before and after interventions. The weight loss and changes in blood pressure, glycemic and lipid profile, and in gut microbiota were investigated. Weight loss was significantly higher (16.2 vs. 11.1 kg, p = 0.022), whereas glycated hemoglobin and triglycerides were lower (−0.46 vs. −0.05%, p = 0.032, and −47.0 vs. −8.5 mg/dL, p = 0.002, respectively) in patients receiving PENS-Diet + probiotics compared with those with a PENS-Diet. Moreover, an enrichment of anti-obesogenic bacteria, including Bifidobacterium spp, Akkermansia spp, Prevotella spp , and the attenuation of the Firmicutes/Bacteroidetes ratio were noted in fecal samples after probiotics administration. In obese patients, the addition of probiotics to a PENS intervention under a hypocaloric diet could further improve weight loss and glycemic and lipid profile in parallel to the amelioration of gut dysbiosis.

Suggested Citation

  • Oscar Lorenzo & Marta Crespo-Yanguas & Tianyu Hang & Jairo Lumpuy-Castillo & Artur M. Hernández & Carolina Llavero & MLuisa García-Alonso & Jaime Ruiz-Tovar, 2020. "Addition of Probiotics to Anti-Obesity Therapy by Percutaneous Electrical Stimulation of Dermatome T6. A Pilot Study," IJERPH, MDPI, vol. 17(19), pages 1-14, October.
  • Handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7239-:d:423561
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/19/7239/pdf
    Download Restriction: no

    File URL: https://www.mdpi.com/1660-4601/17/19/7239/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Catherine A. Lozupone & Jesse I. Stombaugh & Jeffrey I. Gordon & Janet K. Jansson & Rob Knight, 2012. "Diversity, stability and resilience of the human gut microbiota," Nature, Nature, vol. 489(7415), pages 220-230, September.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Diana Cardona & Pablo Roman, 2022. "New Perspectives in Health: Gut Microbiota," IJERPH, MDPI, vol. 19(10), pages 1-3, May.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Jos A. Bosch & Max Nieuwdorp & Aeilko H. Zwinderman & Mélanie Deschasaux & Djawad Radjabzadeh & Robert Kraaij & Mark Davids & Susanne R. Rooij & Anja Lok, 2022. "The gut microbiota and depressive symptoms across ethnic groups," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    2. Kiran Konain & Sadia & Turfa Nadeem & Adeed Khan & Warda Iqbal & Arsalan & Amir Javed & Ruby Khan & Kainat Jamil & Kainat Jamil, 2018. "Importance of Probiotics in Gastrointestinal Tract," Journal of Asian Scientific Research, Asian Economic and Social Society, vol. 8(3), pages 128-143, March.
    3. Khalilullah Mayar & David G. Carmichael & Xuesong Shen, 2022. "Resilience and Systems—A Review," Sustainability, MDPI, vol. 14(14), pages 1-22, July.
    4. Bazeia, D. & Bongestab, M. & de Oliveira, B.F. & Szolnoki, A., 2021. "Effects of a pestilent species on the stability of cyclically dominant species," Chaos, Solitons & Fractals, Elsevier, vol. 151(C).
    5. Jonathan W. Lo & Domenico Cozzetto & James L. Alexander & Nathan P. Danckert & Matthew Madgwick & Naomi Knox & Jillian Yong Xin Sieh & Marton Olbei & Zhigang Liu & Hajir Ibraheim & Jesus Miguens Blanc, 2023. "Immune checkpoint inhibitor-induced colitis is mediated by polyfunctional lymphocytes and is dependent on an IL23/IFNγ axis," Nature Communications, Nature, vol. 14(1), pages 1-20, December.
    6. Monika & Manoj Kumar Verma & Vasim Ahmed & Nar Singh Chauhan, 2017. "Human Gut Microbiome: an Imperative Element for Human Survival," Current Trends in Biomedical Engineering & Biosciences, Juniper Publishers Inc., vol. 6(1), pages 14-15, July.
    7. Hannah E. Laue & Yike Shen & Tessa R. Bloomquist & Haotian Wu & Kasey J. M. Brennan & Raphael Cassoulet & Erin Wilkie & Virginie Gillet & Anne-Sandrine Desautels & Nadia Abdelouahab & Jean Philippe Be, 2022. "In Utero Exposure to Caffeine and Acetaminophen, the Gut Microbiome, and Neurodevelopmental Outcomes: A Prospective Birth Cohort Study," IJERPH, MDPI, vol. 19(15), pages 1-14, July.
    8. Xiaolong Xue & Liang Wang & Rebecca J. Yang, 2018. "Exploring the science of resilience: critical review and bibliometric analysis," Natural Hazards: Journal of the International Society for the Prevention and Mitigation of Natural Hazards, Springer;International Society for the Prevention and Mitigation of Natural Hazards, vol. 90(1), pages 477-510, January.
    9. Elio L Herzog & Melania Wäfler & Irene Keller & Sebastian Wolf & Martin S Zinkernagel & Denise C Zysset-Burri, 2021. "The importance of age in compositional and functional profiling of the human intestinal microbiome," PLOS ONE, Public Library of Science, vol. 16(10), pages 1-13, October.
    10. Debanjan Mukherjee & Ângelo Ferreira Chora & Jean-Christophe Lone & Ricardo S. Ramiro & Birte Blankenhaus & Karine Serre & Mário Ramirez & Isabel Gordo & Marc Veldhoen & Patrick Varga-Weisz & Maria M., 2022. "Host lung microbiota promotes malaria-associated acute respiratory distress syndrome," Nature Communications, Nature, vol. 13(1), pages 1-14, December.
    11. Samuel C. Forster & Junyan Liu & Nitin Kumar & Emily L. Gulliver & Jodee A. Gould & Alejandra Escobar-Zepeda & Tapoka Mkandawire & Lindsay J. Pike & Yan Shao & Mark D. Stares & Hilary P. Browne & B. A, 2022. "Strain-level characterization of broad host range mobile genetic elements transferring antibiotic resistance from the human microbiome," Nature Communications, Nature, vol. 13(1), pages 1-9, December.
    12. Todd D. Terhune & Richard C. Deth, 2018. "Aluminum Adjuvant-Containing Vaccines in the Context of the Hygiene Hypothesis: A Risk Factor for Eosinophilia and Allergy in a Genetically Susceptible Subpopulation?," IJERPH, MDPI, vol. 15(5), pages 1-16, May.
    13. Sarah L Hagerty & Kent E Hutchison & Christopher A Lowry & Angela D Bryan, 2020. "An empirically derived method for measuring human gut microbiome alpha diversity: Demonstrated utility in predicting health-related outcomes among a human clinical sample," PLOS ONE, Public Library of Science, vol. 15(3), pages 1-21, March.
    14. Daniel J Reis & Stephen S Ilardi & Stephanie E W Punt, 2018. "The anxiolytic effect of probiotics: A systematic review and meta-analysis of the clinical and preclinical literature," PLOS ONE, Public Library of Science, vol. 13(6), pages 1-25, June.
    15. Ming Tong & Jinghua Xu & Weixun Li & Kun Jiang & Yan Yang & Zhe Chen & Xuyao Jiao & Xiangfeng Meng & Mingyu Wang & Jie Hong & Hongan Long & Shuang-Jiang Liu & Bentley Lim & Xiang Gao, 2024. "A highly conserved SusCD transporter determines the import and species-specific antagonism of Bacteroides ubiquitin homologues," Nature Communications, Nature, vol. 15(1), pages 1-17, December.
    16. Zhepu Ruan & Kai Chen & Weimiao Cao & Lei Meng & Bingang Yang & Mengjun Xu & Youwen Xing & Pengfa Li & Shiri Freilich & Chen Chen & Yanzheng Gao & Jiandong Jiang & Xihui Xu, 2024. "Engineering natural microbiomes toward enhanced bioremediation by microbiome modeling," Nature Communications, Nature, vol. 15(1), pages 1-19, December.
    17. Alex E. Mohr & Karen L. Sweazea & Devin A. Bowes & Paniz Jasbi & Corrie M. Whisner & Dorothy D. Sears & Rosa Krajmalnik-Brown & Yan Jin & Haiwei Gu & Judith Klein-Seetharaman & Karen M. Arciero & Eric, 2024. "Gut microbiome remodeling and metabolomic profile improves in response to protein pacing with intermittent fasting versus continuous caloric restriction," Nature Communications, Nature, vol. 15(1), pages 1-20, December.
    18. Lena Takayasu & Wataru Suda & Eiichiro Watanabe & Shinji Fukuda & Kageyasu Takanashi & Hiroshi Ohno & Misako Takayasu & Hideki Takayasu & Masahira Hattori, 2017. "A 3-dimensional mathematical model of microbial proliferation that generates the characteristic cumulative relative abundance distributions in gut microbiomes," PLOS ONE, Public Library of Science, vol. 12(8), pages 1-20, August.
    19. Liyan Song, 2023. "Toward Understanding Microbial Ecology to Restore a Degraded Ecosystem," IJERPH, MDPI, vol. 20(5), pages 1-9, March.
    20. Nicole Redvers & Michael Yellow Bird & Diana Quinn & Tyson Yunkaporta & Kerry Arabena, 2020. "Molecular Decolonization: An Indigenous Microcosm Perspective of Planetary Health," IJERPH, MDPI, vol. 17(12), pages 1-13, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:19:p:7239-:d:423561. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.