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Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing

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  • Teodora-Irina Adam-Bonci

    (Pathophysiology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400012 Cluj-Napoca, Romania
    3rd Pediatrics Clinic, Children’s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania)

  • Paraschiva Cherecheș-Panța

    (3rd Pediatrics Clinic, Children’s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania
    3rd Pediatrics Clinic, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania)

  • Eduard-Alexandru Bonci

    (Oncological Surgery and Gynecologic Oncology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania)

  • Sorin Claudiu Man

    (3rd Pediatrics Clinic, Children’s Emergency Hospital Cluj-Napoca, 400217 Cluj-Napoca, Romania
    3rd Pediatrics Clinic, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400217 Cluj-Napoca, Romania)

  • Ancuța Cutaș-Benedec

    (Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania)

  • Tudor Drugan

    (Medical Informatics and Biostatistics, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400349 Cluj-Napoca, Romania)

  • Raluca Maria Pop

    (Pharmacology, Toxicology and Clinical Pharmacology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400337 Cluj-Napoca, Romania)

  • Alexandru Irimie

    (Oncological Surgery and Gynecologic Oncology, “Iuliu Hațieganu” University of Medicine and Pharmacy, 400015 Cluj-Napoca, Romania)

Abstract

Even though vitamin D is widely acknowledged as having a potential immunomodulatory role in asthma, its exact beneficial mechanisms are yet to be clarified. An optimal serum 25-hydroxy-vitamin D (25-OH-VitD) level in pediatric asthma patients might not rely solely on the effect of dose-dependent vitamin D 3 intake, but might also be influenced by factors related to insufficient asthma control. We aimed to survey the prevalence of serum 25-OH-VitD deficiency and analyze whether suboptimal levels were associated with asthma severity factors. The current cross-sectional study enrolled 131 pediatric asthma or asthma-suggestive recurrent wheezing patients, for whom serum 25-OH-VitD, IgE, and eosinophil count were assessed. The prevalence of suboptimal serum 25-OH-VitD was 58.8%. A suboptimal vitamin D status was associated with asthma exacerbation in the previous month ( p = 0.02). Even under seasonal oral vitamin D 3 supplementation, patients with a positive history of asthma attack in the previous four weeks presented significantly lower serum 25-OH-VitD concentrations, compared to their peers with no disease exacerbation. In conclusion, sequential measurements of serum 25-OH-VitD might prove useful for future studies evaluating the dynamic changes in vitamin D 3 status in regard to asthma, especially in symptomatic patients.

Suggested Citation

  • Teodora-Irina Adam-Bonci & Paraschiva Cherecheș-Panța & Eduard-Alexandru Bonci & Sorin Claudiu Man & Ancuța Cutaș-Benedec & Tudor Drugan & Raluca Maria Pop & Alexandru Irimie, 2020. "Suboptimal Serum 25-Hydroxy-Vitamin D Is Associated with a History of Recent Disease Exacerbation in Pediatric Patients with Bronchial Asthma or Asthma-Suggestive Recurrent Wheezing," IJERPH, MDPI, vol. 17(18), pages 1-11, September.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:18:p:6545-:d:410776
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    References listed on IDEAS

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    1. Carmela Protano & Roberta Andreoli & Antonio Mutti & Maurizio Manigrasso & Pasquale Avino & Matteo Vitali, 2018. "Reference Intervals for Urinary Cotinine Levels and the Influence of Sampling Time and Other Predictors on Its Excretion Among Italian Schoolchildren," IJERPH, MDPI, vol. 15(4), pages 1-13, April.
    2. Benjamin Udoka Nwosu & Philip Kum-Nji, 2018. "Tobacco smoke exposure is an independent predictor of vitamin D deficiency in US children," PLOS ONE, Public Library of Science, vol. 13(10), pages 1-12, October.
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