IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v17y2020i14p5171-d386001.html
   My bibliography  Save this article

Baseline Chronic Comorbidity and Mortality in Laboratory-Confirmed COVID-19 Cases: Results from the PRECOVID Study in Spain

Author

Listed:
  • Beatriz Poblador-Plou

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    These authors have equally contributed to this work as first co-authors.)

  • Jonás Carmona-Pírez

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Delicias-Sur Primary Care Health Centre, Aragon Health Service (SALUD), 50009 Zaragoza, Spain
    These authors have equally contributed to this work as first co-authors.)

  • Ignatios Ioakeim-Skoufa

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    These authors have equally contributed to this work as first co-authors.)

  • Antonio Poncel-Falcó

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Aragon Health Service (SALUD), 50017 Zaragoza, Spain
    These authors have equally contributed to this work as first co-authors.)

  • Kevin Bliek-Bueno

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Teaching Unit of Preventive Medicine and Public Health, Miguel Servet University Hospital, 50009 Zaragoza, Spain)

  • Mabel Cano-del Pozo

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    General Directorate of Health Care, Department of Health, Government of Aragon, 50017 Zaragoza, Spain)

  • Luis Andrés Gimeno-Feliú

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    San Pablo Primary Care Health Centre, Aragon Health Service (SALUD), University of Zaragoza, 50003 Zaragoza, Spain)

  • Francisca González-Rubio

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Delicias-Sur Primary Care Health Centre, Aragon Health Service (SALUD), 50009 Zaragoza, Spain)

  • Mercedes Aza-Pascual-Salcedo

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Primary Care Pharmacy Service Zaragoza III, Aragon Health Service (SALUD), 50017 Zaragoza, Spain)

  • Ana Cristina Bandrés-Liso

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Aragon Health Service (SALUD), 50017 Zaragoza, Spain)

  • Jesús Díez-Manglano

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Service of Internal Medicine, Royo Villanova Hospital, Aragon Health Service (SALUD), 50015 Zaragoza, Spain)

  • Javier Marta-Moreno

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    Service of Neurology, Miguel Servet University Hospital, Aragon Health Service (SALUD), 50009 Zaragoza, Spain)

  • Sara Mucherino

    (CIRFF, Center of Pharmacoeconomics, Department of Pharmacy, University of Naples Federico II, 80138 Napoli, Italy)

  • Antonio Gimeno-Miguel

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    These authors have equally contributed to this work as senior co-authors.)

  • Alexandra Prados-Torres

    (EpiChron Research Group, Aragon Health Sciences Institute (IACS), IIS Aragón, Miguel Servet University Hospital, 50009 Zaragoza, Spain
    Health Services Research on Chronic Patients Network (REDISSEC), ISCIII, 28222 Madrid, Spain
    These authors have equally contributed to this work as senior co-authors.)

  • EpiChron Group

    (A complete list of the centres and investigators in the EpiChron Group is provided in Appendix A .)

Abstract

We aimed to analyze baseline socio-demographic and clinical factors associated with an increased likelihood of mortality in men and women with coronavirus disease (COVID-19). We conducted a retrospective cohort study (PRECOVID Study) on all 4412 individuals with laboratory-confirmed COVID-19 in Aragon, Spain, and followed them for at least 30 days from cohort entry. We described the socio-demographic and clinical characteristics of all patients of the cohort. Age-adjusted logistic regressions models were performed to analyze the likelihood of mortality based on demographic and clinical variables. All analyses were stratified by sex. Old age, specific diseases such as diabetes, acute myocardial infarction, or congestive heart failure, and dispensation of drugs like vasodilators, antipsychotics, and potassium-sparing agents were associated with an increased likelihood of mortality. Our findings suggest that specific comorbidities, mainly of cardiovascular nature, and medications at the time of infection could explain around one quarter of the mortality in COVID-19 disease, and that women and men probably share similar but not identical risk factors. Nonetheless, the great part of mortality seems to be explained by other patient- and/or health-system-related factors. More research is needed in this field to provide the necessary evidence for the development of early identification strategies for patients at higher risk of adverse outcomes.

Suggested Citation

  • Beatriz Poblador-Plou & Jonás Carmona-Pírez & Ignatios Ioakeim-Skoufa & Antonio Poncel-Falcó & Kevin Bliek-Bueno & Mabel Cano-del Pozo & Luis Andrés Gimeno-Feliú & Francisca González-Rubio & Mercedes , 2020. "Baseline Chronic Comorbidity and Mortality in Laboratory-Confirmed COVID-19 Cases: Results from the PRECOVID Study in Spain," IJERPH, MDPI, vol. 17(14), pages 1-14, July.
    • Handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5171-:d:386001
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/17/14/5171/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/17/14/5171/
    Download Restriction: no
    ---><---

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Ignatios Ioakeim-Skoufa & Mercedes Clerencia-Sierra & Aida Moreno-Juste & Carmen Elías de Molins Peña & Beatriz Poblador-Plou & Mercedes Aza-Pascual-Salcedo & Francisca González-Rubio & Alexandra Prad, 2022. "Multimorbidity Clusters in the Oldest Old: Results from the EpiChron Cohort," IJERPH, MDPI, vol. 19(16), pages 1-15, August.
    2. Jonás Carmona-Pírez & Ignatios Ioakeim-Skoufa & Antonio Gimeno-Miguel & Beatriz Poblador-Plou & Francisca González-Rubio & Dolores Muñoyerro-Muñiz & Juliana Rodríguez-Herrera & Juan Antonio Goicoechea, 2022. "Multimorbidity Profiles and Infection Severity in COVID-19 Population Using Network Analysis in the Andalusian Health Population Database," IJERPH, MDPI, vol. 19(7), pages 1-13, March.
    3. Nicolás Francisco Fernández-Martínez & Rocío Ortiz-González-Serna & Álvaro Serrano-Ortiz & Mario Rivera-Izquierdo & Rafael Ruiz-Montero & Marina Pérez-Contreras & Inmaculada Guerrero-Fernández de Alba, 2021. "Sex Differences and Predictors of In-Hospital Mortality among Patients with COVID-19: Results from the ANCOHVID Multicentre Study," IJERPH, MDPI, vol. 18(17), pages 1-16, August.
    4. Kevin Bliek-Bueno & Sara Mucherino & Beatriz Poblador-Plou & Francisca González-Rubio & Mercedes Aza-Pascual-Salcedo & Valentina Orlando & Mercedes Clerencia-Sierra & Ignatios Ioakeim-Skoufa & Enrico , 2021. "Baseline Drug Treatments as Indicators of Increased Risk of COVID-19 Mortality in Spain and Italy," IJERPH, MDPI, vol. 18(22), pages 1-10, November.
    5. Samuel Domínguez-Amarillo & Jesica Fernández-Agüera & Sonia Cesteros-García & Roberto Alonso González-Lezcano, 2020. "Bad Air Can Also Kill: Residential Indoor Air Quality and Pollutant Exposure Risk during the COVID-19 Crisis," IJERPH, MDPI, vol. 17(19), pages 1-33, September.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:17:y:2020:i:14:p:5171-:d:386001. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    We have no bibliographic references for this item. You can help adding them by using this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.