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Cyclical DNA methylation of a transcriptionally active promoter

Author

Listed:
  • Raphaël Métivier

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

  • Rozenn Gallais

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

  • Christophe Tiffoche

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

  • Christine Le Péron

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

  • Renata Z. Jurkowska

    (Jacobs University Bremen, Campus Ring 1)

  • Richard P. Carmouche

    (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • David Ibberson

    (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Peter Barath

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu
    Present addresses: Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, SK-833 91 Bratislava, Slovak Republic (P.B.); Science Foundation Ireland, Wilton Park House, Wilton Place, Dublin 2, Ireland (F.G.).)

  • Florence Demay

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

  • George Reid

    (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Vladimir Benes

    (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany)

  • Albert Jeltsch

    (Jacobs University Bremen, Campus Ring 1)

  • Frank Gannon

    (EMBL, Meyerhofstrasse 1, D-69117 Heidelberg, Germany
    Present addresses: Cancer Research Institute, Slovak Academy of Sciences, Vlarska 7, SK-833 91 Bratislava, Slovak Republic (P.B.); Science Foundation Ireland, Wilton Park House, Wilton Place, Dublin 2, Ireland (F.G.).)

  • Gilles Salbert

    (Université de Rennes I, CNRS, UMR 6026 Equipe SPARTE, IFR 140 GFAS, Campus de Beaulieu)

Abstract

Processes that regulate gene transcription are directly under the influence of the genome organization. The epigenome contains additional information that is not brought by DNA sequence, and generates spatial and functional constraints that complement genetic instructions. DNA methylation on CpGs constitutes an epigenetic mark generally correlated with transcriptionally silent condensed chromatin. Replication of methylation patterns by DNA methyltransferases maintains genome stability through cell division. Here we present evidence of an unanticipated dynamic role for DNA methylation in gene regulation in human cells. Periodic, strand-specific methylation/demethylation occurs during transcriptional cycling of the pS2/TFF1 gene promoter on activation by oestrogens. DNA methyltransferases exhibit dual actions during these cycles, being involved in CpG methylation and active demethylation of 5mCpGs through deamination. Inhibition of this process precludes demethylation of the pS2 gene promoter and its subsequent transcriptional activation. Cyclical changes in the methylation status of promoter CpGs may thus represent a critical event in transcriptional achievement.

Suggested Citation

  • Raphaël Métivier & Rozenn Gallais & Christophe Tiffoche & Christine Le Péron & Renata Z. Jurkowska & Richard P. Carmouche & David Ibberson & Peter Barath & Florence Demay & George Reid & Vladimir Bene, 2008. "Cyclical DNA methylation of a transcriptionally active promoter," Nature, Nature, vol. 452(7183), pages 45-50, March.
    • Handle: RePEc:nat:nature:v:452:y:2008:i:7183:d:10.1038_nature06544
    DOI: 10.1038/nature06544
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    Cited by:

    1. Ting Jiang & Xue Li & Li Ning & Jiwen Liu, 2019. "Cross-Sectional Survey of Mental Health Risk Factors and Comparison of the Monoamine oxidase A Gene DNA Methylation Level in Different Mental Health Conditions among Oilfield Workers in Xinjiang, Chin," IJERPH, MDPI, vol. 17(1), pages 1-15, December.

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