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Management of STEC Gastroenteritis: Is There a Role for Probiotics?

Author

Listed:
  • Mario Giordano

    (Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy
    These authors contributed equally to this work.)

  • Maria Elisabetta Baldassarre

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy
    These authors contributed equally to this work.)

  • Viviana Palmieri

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy)

  • Diletta D. Torres

    (Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy)

  • Vincenza Carbone

    (Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy)

  • Luisa Santangelo

    (Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy)

  • Federico Gentile

    (Pediatric Nephrology and Dialysis Unit, Pediatric Hospital “Giovanni XXIII”, Bari 70123, Italy)

  • Raffaella Panza

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy)

  • Federica Di Mauro

    (Department of Public Health, University of Naples Federico II, Napoli 80138, Italy)

  • Manuela Capozza

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy)

  • Antonio Di Mauro

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy)

  • Nicola Laforgia

    (Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, “Aldo Moro” University of Bari, Bari 70124, Italy)

Abstract

Shiga toxin-producing Escherichia Coli (STEC) infections routinely run as a common gastroenteritis, but in many cases they may evolve towards hemolytic uremic syndrome (HUS). HUS is a rare disease characterized by microangiopathic hemolytic anemia, thrombocytopenia, and acute renal failure. Gut microorganisms have a fundamental impact on human physiology, because they modulate normal intestinal functions and play a pivotal role in influencing the local and systemic immune responses. Despite surveillance established in many countries and major progresses in the understanding of STEC-HUS mechanisms, no specific treatment is currently available. Targeting the gut microbiota could represent a new potential therapeutic strategy in STEC infection. In this paper, we reviewed the current knowledge about microbiota characteristics of patients with STEC infections, as well as in vitro and in vivo evidence of probiotic supplementation in managing STEC gastroenteritis and in HUS onset prevention.

Suggested Citation

  • Mario Giordano & Maria Elisabetta Baldassarre & Viviana Palmieri & Diletta D. Torres & Vincenza Carbone & Luisa Santangelo & Federico Gentile & Raffaella Panza & Federica Di Mauro & Manuela Capozza & , 2019. "Management of STEC Gastroenteritis: Is There a Role for Probiotics?," IJERPH, MDPI, vol. 16(9), pages 1-8, May.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:9:p:1649-:d:230406
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    References listed on IDEAS

    as
    1. Sabina Fijan, 2014. "Microorganisms with Claimed Probiotic Properties: An Overview of Recent Literature," IJERPH, MDPI, vol. 11(5), pages 1-23, May.
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