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Toxic Effects of TiO 2 NPs on Zebrafish

Author

Listed:
  • Tianle Tang

    (School of Tropical Medicine and Laboratory Medicine, Hainan Medical University, Haikou 570228, China
    Key Laboratory of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou 570228, China)

  • Zhang Zhang

    (Key Laboratory of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou 570228, China)

  • Xiaopeng Zhu

    (Key Laboratory of Tropical Biological Resources, Ministry of Education, Hainan University, Haikou 570228, China)

Abstract

Titanium dioxide nanoparticles (TiO 2 NPs) have become a widely used nanomaterial due to the photocatalytic activity and absorption of ultraviolet light of specific wavelengths. This study investigated the toxic effects of rutile TiO 2 NPs on zebrafish by examining its embryos and adults. In the embryo acute toxicity test, exposure to 100 mg/L TiO 2 NPs didn’t affect the hatching rate of zebrafish embryos, and there was no sign of deformity. In the adult toxicity test, the effects of TiO 2 NPs on oxidative damage in liver, intestine and gill tissue were studied. Enzyme linked immunosorbent assay (ELISA) and fluorescence-based quantitative real-time reverse transcription PCR (qRT-PCR) were used to detect the three antioxidant enzymes: superoxide dismutase (SOD), catalase (CAT) and glutathione S transferase (GSTs) in the above mentioned zebrafish organs at protein and gene levels. The results showed that long-term exposure to TiO 2 NPs can cause oxidative damage to organisms; and compared with the control group, the activity of the three kinds of enzyme declined somewhat at the protein level. In addition, long-term exposure to TiO 2 NPs could cause high expression of CAT, SOD and GSTs in three organs of adult zebrafish in order to counter the adverse reaction. The effects of long-term exposure to TiO 2 NPs to adult zebrafish were more obvious in the liver and gill.

Suggested Citation

  • Tianle Tang & Zhang Zhang & Xiaopeng Zhu, 2019. "Toxic Effects of TiO 2 NPs on Zebrafish," IJERPH, MDPI, vol. 16(4), pages 1-14, February.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:4:p:523-:d:205335
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    References listed on IDEAS

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    1. Tianle Tang & Yang Yang & Yawen Chen & Wenhao Tang & Fuqiang Wang & Xiaoping Diao, 2015. "Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF," IJERPH, MDPI, vol. 12(10), pages 1-16, October.
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    Cited by:

    1. Qin Wang & Yi Zhu & Bin Song & Rong Fu & Yanfeng Zhou, 2022. "The In Vivo Toxicity Assessments of Water-Dispersed Fluorescent Silicon Nanoparticles in Caenorhabditis elegans," IJERPH, MDPI, vol. 19(7), pages 1-13, March.

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