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Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF

Author

Listed:
  • Tianle Tang

    (College of Environment and Plant Protection, Hainan University, Haikou 570228, China
    School of Tropical and Laboratory Medicine, Hainan Medical University, Haikou 571199, China)

  • Yang Yang

    (College of Environment and Plant Protection, Hainan University, Haikou 570228, China)

  • Yawen Chen

    (College of Environment and Plant Protection, Hainan University, Haikou 570228, China)

  • Wenhao Tang

    (College of Environment and Plant Protection, Hainan University, Haikou 570228, China
    Haikou Key Laboratory of Environment Toxicology, Hainan University, Haikou 570228, China)

  • Fuqiang Wang

    (College of Environment and Plant Protection, Hainan University, Haikou 570228, China)

  • Xiaoping Diao

    (Haikou Key Laboratory of Environment Toxicology, Hainan University, Haikou 570228, China)

Abstract

Bisphenol AF (BPAF) is extensively used as a raw material in industry, resulting in its widespread distribution in the aqueous environment. However, the effect of BPAF on the hypothalamic-pituitary-thyroidal (HPT) axis remains unknown. For elucidating the disruptive effects of BPAF on thyroid function and expression of the representative genes along the HPT axis in zebrafish ( Danio rerio ) embryos, whole-body total 3,3′,5-triiodothyronine (TT3), total 3,5,3′,5′-tetraiodothyronine (TT4), free 3,3′,5-triiodothyronine (FT3) and free 3,5,3′,5′-tetraiodothyronine (FT4) levels were examined following 168 h post-fertilization exposure to different BPAF concentrations (0, 5, 50 and 500 μg/L). The results showed that whole-body TT3, TT4, FT3 and FT4 contents decreased significantly with the BPAF treatment, indicating an endocrine disruption of thyroid. The expression of thyroid-stimulating hormone-β and thyroglobulin genes increased after exposing to 50 μg/L BPAF in seven-day-old larvae. The expressions of thyronine deiodinases type 1, type 2 and transthyretin mRNAs were also significantly up-regulated, which were possibly associated with a deterioration of thyroid function. However, slc5a5 gene transcription was significantly down-regulated at 50 μg/L and 500 μg/L BPAF exposure. Furthermore, tr α and tr β genes were down-regulated transcriptionally after BPAF exposure. It demonstrates that BPAF exposure triggered thyroid endocrine toxicity by altering the whole-body contents of thyroid hormones and changing the transcription of the genes involved in the HPT axis in zebrafish larvae.

Suggested Citation

  • Tianle Tang & Yang Yang & Yawen Chen & Wenhao Tang & Fuqiang Wang & Xiaoping Diao, 2015. "Thyroid Disruption in Zebrafish Larvae by Short-Term Exposure to Bisphenol AF," IJERPH, MDPI, vol. 12(10), pages 1-16, October.
    • Handle: RePEc:gam:jijerp:v:12:y:2015:i:10:p:13069-13084:d:57243
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    Cited by:

    1. Tianle Tang & Zhang Zhang & Xiaopeng Zhu, 2019. "Toxic Effects of TiO 2 NPs on Zebrafish," IJERPH, MDPI, vol. 16(4), pages 1-14, February.
    2. Francesca Gorini & Elisa Bustaffa & Alessio Coi & Giorgio Iervasi & Fabrizio Bianchi, 2020. "Bisphenols as Environmental Triggers of Thyroid Dysfunction: Clues and Evidence," IJERPH, MDPI, vol. 17(8), pages 1-46, April.

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