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Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area

Author

Listed:
  • Marina M. S. Cabral Pinto

    (Geobiotec Research Centre, Department of Geosciences, University of Aveiro, 3810-193 Aveiro, Portugal)

  • Paula Marinho-Reis

    (Instituto de Ciências da Terra, University of Minho, 4710–057 Braga, Portugal)

  • Agostinho Almeida

    (Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, LAQV/REQUIMTE, Porto University, 4050-313 Porto, Portugal)

  • Edgar Pinto

    (Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, LAQV/REQUIMTE, Porto University, 4050-313 Porto, Portugal)

  • Orquídia Neves

    (CERENA, DECivil, Instituto Superior Técnico, University of Lisbon, 1049-001 Lisbon, Portugal)

  • Manuela Inácio

    (Geobiotec Research Centre, Department of Geosciences, University of Aveiro, 3810-193 Aveiro, Portugal)

  • Bianca Gerardo

    (Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), University of Coimbra, 3030-548 Coimbra, Portugal)

  • Sandra Freitas

    (Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), University of Coimbra, 3030-548 Coimbra, Portugal)

  • Mário R. Simões

    (Center for Research in Neuropsychology and Cognitive and Behavioral Intervention (CINEICC), University of Coimbra, 3030-548 Coimbra, Portugal)

  • Pedro A. Dinis

    (MARE—Marine and Environmental Sciences Centre, Department of Earth Sciences, University of Coimbra, 3030-790 Coimbra, Portugal)

  • Luísa Diniz

    (Laboratory of Applied Chemistry, Department of Chemical Sciences, Faculty of Pharmacy, LAQV/REQUIMTE, Porto University, 4050-313 Porto, Portugal)

  • Eduardo Ferreira da Silva

    (Geobiotec Research Centre, Department of Geosciences, University of Aveiro, 3810-193 Aveiro, Portugal)

  • Paula I. Moreira

    (CNC—Center for Neuroscience and Cell Biology, University of Coimbra and Institute of Physiology, Faculty of Medicine, University of Coimbra, 3030-548 Coimbra, Portugal)

Abstract

In the present study, trace elements (TE) levels were evaluated in scalp hair along the continuum from healthy subjects (HS) to patients suffering from subjective memory concerns (SMC), and/or mild cognitive impairment (MCI), and those with already installed dementia (DEM) in order to: (i) assess the effects of environmental and lifestyle factors on TE concentrations and (ii) evaluate the analyzed elements as possible diagnostic biomarkers for the disease. The study involved 79 mainly permanent residents, >55 years old, from the city of Estarreja (northern Portugal), a former industrial area. The health status of the participants was assessed by means of a complete socio-demographic questionnaire and through cognitive screening tests, namely the Mini-Mental State Examination (MMSE). The test scores were categorized and used in the statistical analysis. Hair samples were collected and analyzed by inductively coupled plasma-mass spectrometry (ICP-MS) ICP-MS for selected TE. Dementia appears to be associated with higher age, the female gender, lower education level, and longer residence time in the study area. In addition, most of the participants diagnosed with dementia frequently consume home-grown foodstuffs, some irrigated with contaminated well water. The calculation of the TE enrichment factors of soil samples collected in kitchen gardens/small farms in the vicinity of the Estarreja Chemical Complex (ECC) reinforces the degree of Hg soil contamination in the area, due to anthropogenic sources that can be a source for the population Hg exposure route among others. Mercury levels in hair differed significantly between the four individual groups (HS, SMC, MCI, and DEM), increasing from healthy to dementia participants. Improved diagnostic results can be obtained using hair TE signatures coupled with MMSE scores. This strategy may prove useful for predictive diagnosis in population screening for cognitive impairment.

Suggested Citation

  • Marina M. S. Cabral Pinto & Paula Marinho-Reis & Agostinho Almeida & Edgar Pinto & Orquídia Neves & Manuela Inácio & Bianca Gerardo & Sandra Freitas & Mário R. Simões & Pedro A. Dinis & Luísa Diniz & , 2019. "Links between Cognitive Status and Trace Element Levels in Hair for an Environmentally Exposed Population: A Case Study in the Surroundings of the Estarreja Industrial Area," IJERPH, MDPI, vol. 16(22), pages 1-20, November.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:22:p:4560-:d:288204
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    References listed on IDEAS

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    1. Karen Andersen-Ranberg & Lone Vasegaard & Bernard Jeune, 2001. "Dementia Is Not Inevitable," The Journals of Gerontology: Series B, The Gerontological Society of America, vol. 56(3), pages 152-159.
    2. Li, Jinhu & Powdthavee, Nattavudh, 2015. "Does more education lead to better health habits? Evidence from the school reforms in Australia," Social Science & Medicine, Elsevier, vol. 127(C), pages 83-91.
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    Cited by:

    1. Siyoon Kwon & Hyoseob Noh & Il Won Seo & Sung Hyun Jung & Donghae Baek, 2021. "Identification Framework of Contaminant Spill in Rivers Using Machine Learning with Breakthrough Curve Analysis," IJERPH, MDPI, vol. 18(3), pages 1-26, January.
    2. Bianca Gerardo & Marina Cabral Pinto & Joana Nogueira & Paula Pinto & Agostinho Almeida & Edgar Pinto & Paula Marinho-Reis & Luísa Diniz & Paula I. Moreira & Mário R. Simões & Sandra Freitas, 2020. "Associations between Trace Elements and Cognitive Decline: An Exploratory 5-Year Follow-Up Study of an Elderly Cohort," IJERPH, MDPI, vol. 17(17), pages 1-18, August.
    3. Luísa Diniz & Gelson Carlos & Carmelita Miranda & Pedro Dinis & Rosa Marques & Fernando Tavares Rocha & Eduardo Ferreira da Silva & Agostinho Almeida & Marina Cabral Pinto, 2024. "Soil Geochemical Mapping of the Sal Island (Cape Verde): Ecological and Human Health Risk Assessment," Land, MDPI, vol. 13(8), pages 1-17, July.
    4. Huan Li & Liyuan Chai & Zhihui Yang & Weichun Yang & Qi Liao & Zhe Cao & Yanchun Peng, 2020. "Systematic Assessment of Health Risk from Metals in Surface Sediment of the Xiangjiang River, China," IJERPH, MDPI, vol. 17(5), pages 1-17, March.

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