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New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease

Author

Listed:
  • Airton Cunha Martins

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA)

  • Patricia Morcillo

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA)

  • Omamuyovwi Meashack Ijomone

    (Department of Human Anatomy, School of Health and Health Technology, Federal University of Technology Akure, Akure 340252, Nigeria)

  • Vivek Venkataramani

    (Department of Hematology and Medical Oncology and Institute of Pathology, University Medical Center Göttingen (UMG), 37075 Göttingen, Germany)

  • Fiona Edith Harrison

    (Department of Medicine, Vanderbilt University Medical Center, Nashville, TN 37232, USA)

  • Eunsook Lee

    (Department of Pharmaceutical Sciences, Florida A&M University, Tallahassee, FL 32301, USA)

  • Aaron Blaine Bowman

    (School of Health Sciences, Purdue University, West Lafayette, IN 47907-2051, USA)

  • Michael Aschner

    (Department of Molecular Pharmacology, Albert Einstein College of Medicine, Bronx, NY 10461, USA)

Abstract

Manganese (Mn) is an essential trace element that is naturally found in the environment and is necessary as a cofactor for many enzymes and is important in several physiological processes that support development, growth, and neuronal function. However, overexposure to Mn may induce neurotoxicity and may contribute to the development of Alzheimer’s disease (AD) and Parkinson’s disease (PD). The present review aims to provide new insights into the involvement of Mn in the etiology of AD and PD. Here, we discuss the critical role of Mn in the etiology of these disorders and provide a summary of the proposed mechanisms underlying Mn-induced neurodegeneration. In addition, we review some new therapy options for AD and PD related to Mn overload.

Suggested Citation

  • Airton Cunha Martins & Patricia Morcillo & Omamuyovwi Meashack Ijomone & Vivek Venkataramani & Fiona Edith Harrison & Eunsook Lee & Aaron Blaine Bowman & Michael Aschner, 2019. "New Insights on the Role of Manganese in Alzheimer’s Disease and Parkinson’s Disease," IJERPH, MDPI, vol. 16(19), pages 1-16, September.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:19:p:3546-:d:269608
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    References listed on IDEAS

    as
    1. Gunnar F. Kwakye & Monica M.B. Paoliello & Somshuvra Mukhopadhyay & Aaron B. Bowman & Michael Aschner, 2015. "Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features," IJERPH, MDPI, vol. 12(7), pages 1-22, July.
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    Cited by:

    1. Yudha Gusti Wibowo & Hana Safitri & Ida Bagus Ilham Malik & Sudibyo & Sugeng Priyanto, 2022. "Alternative Low-Cost Treatment for Real Acid Mine Drainage: Performance, Bioaccumulation, Translocation, Economic, Post-Harvest, and Bibliometric Analyses," Sustainability, MDPI, vol. 14(22), pages 1-16, November.

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