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C. elegans —An Emerging Model to Study Metal-Induced RAGE-Related Pathologies

Author

Listed:
  • Adi Pinkas

    (Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Forchheimer Building, Room 209, Bronx, New York, NY 10461, USA)

  • Airton Cunha Martins

    (Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Forchheimer Building, Room 209, Bronx, New York, NY 10461, USA)

  • Michael Aschner

    (Albert Einstein College of Medicine, Jack and Pearl Resnick Campus, 1300 Morris Park Avenue, Forchheimer Building, Room 209, Bronx, New York, NY 10461, USA)

Abstract

The receptor for advanced glycation end products (RAGE), a multi-ligand receptor, is mostly associated with promoting inflammation and oxidative stress. In addition to advanced glycation end products (AGEs), its ligands include High mobility group box 1 protein (HMGB-1), S-100 proteins and beta-sheet fibrils. The effects of several metals and metalloids on RAGE expression and activation have been recently studied: in vivo and in vitro exposure to methylmercury, selenium, zinc, manganese, and arsenic was associated with a variety of RAGE-related alterations and behavioral impairments, which are mostly dependent upon the administration procedure (local vs. systemic) and age during exposure. Recently, C. elegans has been proposed as a potential novel model for studying RAGE-related pathologies; preliminary data regarding such model and its potential contribution to the study of metal-induced RAGE-related pathologies are discussed.

Suggested Citation

  • Adi Pinkas & Airton Cunha Martins & Michael Aschner, 2018. "C. elegans —An Emerging Model to Study Metal-Induced RAGE-Related Pathologies," IJERPH, MDPI, vol. 15(7), pages 1-8, July.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:7:p:1407-:d:156133
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    References listed on IDEAS

    as
    1. Gunnar F. Kwakye & Monica M.B. Paoliello & Somshuvra Mukhopadhyay & Aaron B. Bowman & Michael Aschner, 2015. "Manganese-Induced Parkinsonism and Parkinson’s Disease: Shared and Distinguishable Features," IJERPH, MDPI, vol. 12(7), pages 1-22, July.
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