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Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population

Author

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  • Giovanna Tranfo

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

  • Enrico Paci

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

  • Mariella Carrieri

    (Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani 2, 35128 Padova, Italy)

  • Enrico Marchetti

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

  • Renata Sisto

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

  • Monica Gherardi

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

  • Francesca Costabile

    (CNR-ISAC—Italian National Research Council, Institute of Atmospheric Science and Climate, via Fosso del Cavaliere 100, 00133 Rome, Italy)

  • Lisa Bauleo

    (Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo 112, 00147 Rome, Italy)

  • Carla Ancona

    (Department of Epidemiology, Lazio Regional Health Service, Via Cristoforo Colombo 112, 00147 Rome, Italy)

  • Daniela Pigini

    (Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene, INAIL Research, via Fontana Candida 1, Monte Porzio Catone, 00078 Rome, Italy)

Abstract

(1) Background : The products of guanine oxidation in DNA and RNA excreted in urine are 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and 8-oxo-7,8-dihydro-2’-deoxyguanosine (8-oxodGuo). Despite intra and inter-individual variability, it is possible to identify situations that significantly increase the levels of these compounds when comparing urinary concentrations of some workers to those of the general population. (2) Methods : urines from gasoline pump attendants (58 from Saudi Arabia and 102 from Italy), 24 workers of a fiberglass reinforced plastics plant, 17 painters and 6 divers were analyzed by HPLC/MS-MS. To test the individual variability, two subjects provided daily samples for one month, and 132 urine samples from the general population were analyzed. (3) Results : We summarized the results for each biomarker, and found the following were statistically higher than in the general population: 8-oxoGua in fiberglass and Italian gasoline workers; 8-oxodGuo in fiberglass and both Saudi Arabian and Italian gasoline workers; 8-oxoGuo in fiberglass workers, both Saudi Arabian and Italian gasoline workers, and painters after the working shift. (4) Conclusions : these results confirm that both 8-oxodGuo and 8-oxoGuo are valuable biomarkers for occupational exposures to dangerous chemicals and seem to suggest that 8-oxoGuo, related to RNA oxidation, is a suitable biomarker to evaluate short term, reversible effects of occupational exposures even within the health-based limit values.

Suggested Citation

  • Giovanna Tranfo & Enrico Paci & Mariella Carrieri & Enrico Marchetti & Renata Sisto & Monica Gherardi & Francesca Costabile & Lisa Bauleo & Carla Ancona & Daniela Pigini, 2019. "Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population," IJERPH, MDPI, vol. 16(16), pages 1-13, August.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:16:p:2995-:d:259169
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    References listed on IDEAS

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    1. Mariella Carrieri & Daniela Pigini & Andrea Martinelli & Enrico Paci & Federica Maratini & Fabiola Salamon & Giovanna Tranfo, 2019. "Effect of Benzene Exposure on the Urinary Biomarkers of Nucleic Acid Oxidation in Two Cohorts of Gasoline Pump Attendants," IJERPH, MDPI, vol. 16(1), pages 1-10, January.
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    Cited by:

    1. Flavia Buonaurio & Maria Luisa Astolfi & Silvia Canepari & Marco Di Basilio & Rocco Gibilras & Marco Mecchia & Maddalena Papacchini & Enrico Paci & Daniela Pigini & Giovanna Tranfo, 2020. "Urinary Oxidative Stress Biomarkers in Workers of a Titanium Dioxide Based Pigment Production Plant," IJERPH, MDPI, vol. 17(23), pages 1-11, December.
    2. Enrico Marchetti & Daniela Pigini & Mariangela Spagnoli & Giovanna Tranfo & Flavia Buonaurio & Fabio Sciubba & Ottavia Giampaoli & Alfredo Miccheli & Alessandro Pinto & Nazzareno De Angelis & Luigi Fa, 2022. "Hyperbaric Exposure of Scuba Divers Affects the Urinary Excretion of Nucleic Acid Oxidation Products and Hypoxanthine," IJERPH, MDPI, vol. 19(5), pages 1-13, March.
    3. Delia Cavallo & Cinzia Lucia Ursini & Anna Maria Fresegna & Aureliano Ciervo & Raffaele Maiello & Giuliana Buresti & Enrico Paci & Daniela Pigini & Monica Gherardi & Damiano Carbonari & Renata Sisto &, 2021. "Occupational Exposure in Industrial Painters: Sensitive and Noninvasive Biomarkers to Evaluate Early Cytotoxicity, Genotoxicity and Oxidative Stress," IJERPH, MDPI, vol. 18(9), pages 1-14, April.

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