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Effect of Benzene Exposure on the Urinary Biomarkers of Nucleic Acid Oxidation in Two Cohorts of Gasoline Pump Attendants

Author

Listed:
  • Mariella Carrieri

    (Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, 35128 Padova, Italy)

  • Daniela Pigini

    (INAIL Research, Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene Via di Fontana Candida 1, 00040 Monte Porzio Catone, Rome, Italy)

  • Andrea Martinelli

    (Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, 35128 Padova, Italy)

  • Enrico Paci

    (INAIL Research, Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene Via di Fontana Candida 1, 00040 Monte Porzio Catone, Rome, Italy)

  • Federica Maratini

    (Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, 35128 Padova, Italy)

  • Fabiola Salamon

    (Department of Cardiac, Thoracic, Vascular Sciences and Public Health, University of Padova, via Giustiniani, 2, 35128 Padova, Italy)

  • Giovanna Tranfo

    (INAIL Research, Department of Occupational Medicine, Epidemiology, Occupational and Environmental Hygiene Via di Fontana Candida 1, 00040 Monte Porzio Catone, Rome, Italy)

Abstract

(1) Background: The oxidized guanine derivatives excreted into urine, products of DNA and RNA oxidation and repair, are used as biomarkers of oxidative damage in humans. This study aims to evaluate oxidative damage in gasoline pump attendants occupationally exposed to benzene. Benzene is contained in the gasoline but it is also produced from traffic and from smoking. (2) Methods: Twenty-nine gasoline pump attendants from two major cities of Saudi Arabia and 102 from Italy were studied for urinary 8-oxo-7,8-dihydroguanine (8-oxoGua), 8-oxo-7,8-dihydro-2′-deoxyguanosine (8-oxodGuo), 8-oxo-7,8-dihydroguanosine (8-oxoGuo), and S-phenyl-mercapturic acid (SPMA) for benzene exposure and urinary cotinine for smoking status assessment by liquid chromatography-tandem mass spectrometry. Airborne benzene was also assessed in the Italian group by gas-chromatography with flame ionization detector (GC-FID). (3) Results: The results suggest that high levels of benzene exposure can cause an accumulation of SPMA and bring about the formation of the oxidation biomarkers studied to saturation. At low exposure levels, SPMA and oxidation biomarker levels were correlated among them and were associated with the smoking habit. (4) Conclusions: The study confirms the association between benzene exposure and the excretion of nucleic acid oxidation biomarkers and enhances the importance of measuring the smoking habit, as it can significantly influence oxidative damage, especially when the exposure levels are low.

Suggested Citation

  • Mariella Carrieri & Daniela Pigini & Andrea Martinelli & Enrico Paci & Federica Maratini & Fabiola Salamon & Giovanna Tranfo, 2019. "Effect of Benzene Exposure on the Urinary Biomarkers of Nucleic Acid Oxidation in Two Cohorts of Gasoline Pump Attendants," IJERPH, MDPI, vol. 16(1), pages 1-10, January.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:1:p:129-:d:195143
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    Cited by:

    1. Giovanna Tranfo & Enrico Paci & Mariella Carrieri & Enrico Marchetti & Renata Sisto & Monica Gherardi & Francesca Costabile & Lisa Bauleo & Carla Ancona & Daniela Pigini, 2019. "Levels of Urinary Biomarkers of Oxidatively Generated Damage to DNA and RNA in Different Groups of Workers Compared to General Population," IJERPH, MDPI, vol. 16(16), pages 1-13, August.

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