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The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism ( ANKK1 Taq1A ) and Personality Traits in Addicted Subjects

Author

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  • Anna Grzywacz

    (Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland)

  • Jolanta Chmielowiec

    (Department of Hygiene and Epidemiology, Faculty of Medicine and Health Science, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland)

  • Krzysztof Chmielowiec

    (Department of Hygiene and Epidemiology, Faculty of Medicine and Health Science, University of Zielona Góra, 28 Zyty St., 65-046 Zielona Góra, Poland)

  • Bożena Mroczek

    (Department of Human Sciences in Medicine, Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland)

  • Jolanta Masiak

    (Neurophysiological Independent Unit, Department of Psychiatry, Medical University of Lublin, 1 Aleje Racławickie St., 20-059 Lublin, Poland)

  • Aleksandra Suchanecka

    (Independent Laboratory of Health Promotion of the Pomeranian Medical University in Szczecin, 11 Chlapowskiego St., 70-204 Szczecin, Poland)

  • Olimpia Sipak-Szmigiel

    (Department of Obstetrics and Pathology of Pregnancy, Pomeranian Medical University in Szczecin, 48 Żołnierska St., 71-210 Szczecin, Poland)

  • Kamila Szumilas

    (Department of General Pathology, Pomeranian Medical University, Szczecin 70-111, Poland)

  • Grzegorz Trybek

    (Department of Oral Surgery, Pomeranian Medical University in Szczecin, 72 Powstańców Wlkp. St., 70-111 Szczecin, Poland)

Abstract

The Taq1A polymorphism located in the ANKK1 gene is one of the most widely studied polymorphisms in regards to the genetics of behavior and addiction. The aim of our study was to analyze this polymorphism with regard to personality characteristics and anxiety measured by means of the Personality Inventory—(NEO Five-Factor Inventory—NEO—FFI) and the State-Trait Anxiety Inventory (STAI) in polysubstance addicted subjects. The study group consisted of 600 male volunteers, including 299 addicted subjects and 301 controls. Psychiatrists recruited members for both groups. Addiction was diagnosed in the case group. In the control group mental illness was excluded. The same psychometric test and genotyping using the real-time PCR (polymerase chain reaction) method was performed for both groups. The results were investigated by means of multivariate analysis of the main effects Multi-factor ANOVA. Significantly higher scores on the scale of STAI state and Neuroticism and Openness traits, as well as lower scores on the scales of Extraversion, Agreeability, and Conscientiousness, were found in the case group subjects, compared to the controls. Differences in frequency of genotypes and alleles of Taq1A polymorphism between the studied groups were not found. Multi-factor ANOVA of addicted subjects and control subjects and the ANKK1 Taq1A variant interaction approximated the statistical significance for the STAI state. The main effects ANOVA of both subjects’ groups were found for the STAI state and trait, the Neuroticism scale, the Extraversion scale, and the Agreeability scale. The ANKK1 Taq1A main effects approximated the statistical significance of the STAI trait. Our study shows not only differences in personality traits between addicted and non-addicted subjects, but also the possible impact of ANKK1 on given traits and on addiction itself.

Suggested Citation

  • Anna Grzywacz & Jolanta Chmielowiec & Krzysztof Chmielowiec & Bożena Mroczek & Jolanta Masiak & Aleksandra Suchanecka & Olimpia Sipak-Szmigiel & Kamila Szumilas & Grzegorz Trybek, 2019. "The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism ( ANKK1 Taq1A ) and Personality Traits in Addicted Subjects," IJERPH, MDPI, vol. 16(15), pages 1-13, July.
    • Handle: RePEc:gam:jijerp:v:16:y:2019:i:15:p:2687-:d:252248
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    References listed on IDEAS

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    1. Jolanta Chmielowiec & Krzysztof Chmielowiec & Aleksandra Suchanecka & Grzegorz Trybek & Bożena Mroczek & Iwona Małecka & Anna Grzywacz, 2018. "Associations Between the Dopamine D4 Receptor and DAT1 Dopamine Transporter Genes Polymorphisms and Personality Traits in Addicted Patients," IJERPH, MDPI, vol. 15(10), pages 1-12, September.
    2. Rafael Maldonado & Adolfo Saiardi & Olga Valverde & Tarek A. Samad & Bernard P. Roques & Emiliana Borrelli, 1997. "Absence of opiate rewarding effects in mice lacking dopamine D2 receptors," Nature, Nature, vol. 388(6642), pages 586-589, August.
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    Cited by:

    1. Aleksandra Suchanecka & Jolanta Chmielowiec & Krzysztof Chmielowiec & Grzegorz Trybek & Aleksandra Jaroń & Wojciech Czarny & Paweł Król & Jolanta Masiak & Anna Grzywacz, 2022. "Serotonin Receptor HTR3A Gene Polymorphisms rs1985242 and rs1062613, E-Cigarette Use and Personality," IJERPH, MDPI, vol. 19(8), pages 1-14, April.
    2. Anna Grzywacz & Aleksandra Suchanecka & Jolanta Chmielowiec & Krzysztof Chmielowiec & Kamila Szumilas & Jolanta Masiak & Łukasz Balwicki & Monika Michałowska-Sawczyn & Grzegorz Trybek, 2020. "Personality Traits or Genetic Determinants—Which Strongly Influences E-Cigarette Users?," IJERPH, MDPI, vol. 17(1), pages 1-15, January.

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