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Absence of opiate rewarding effects in mice lacking dopamine D2 receptors

Author

Listed:
  • Rafael Maldonado

    (Dpartement de Pharmacochimie Molculaire et Structurale, INSERM U266, URA D1500 CNRS, Universit Ren Descartes)

  • Adolfo Saiardi

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM/CNRS/ULP, BP 163)

  • Olga Valverde

    (Dpartement de Pharmacochimie Molculaire et Structurale, INSERM U266, URA D1500 CNRS, Universit Ren Descartes)

  • Tarek A. Samad

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM/CNRS/ULP, BP 163)

  • Bernard P. Roques

    (Dpartement de Pharmacochimie Molculaire et Structurale, INSERM U266, URA D1500 CNRS, Universit Ren Descartes)

  • Emiliana Borrelli

    (Institut de Génétique et de Biologie Moléculaire et Cellulaire, INSERM/CNRS/ULP, BP 163)

Abstract

Dopamine receptors have been implicated in the behavioural response to drugs of abuse. These responses are mediated particularly by the mesolimbic dopaminergic pathway arising in the ventral tegmental area and projecting to the limbic system. The rewarding properties of opiates1 and the somatic expression of morphine abstinence2 have been related to changes in mesolimbic dopaminergic activity that could constitute the neural substrate for opioid addiction3. These adaptive responses to repeated morphine administration have been investigated in mice with a genetic disruption of the dopaminergic D2 receptors4. Although the behavioural expression of morphine withdrawal was unchanged in these mice, a total suppression of morphine rewarding properties was observed in a place-preference test. This effect is specific to the drug, as mice lacking D2 receptors behaved the same as wild-type mice when food is used as reward. We conclude that the D2 receptor plays a crucial role in the motivational component of drug addiction.

Suggested Citation

  • Rafael Maldonado & Adolfo Saiardi & Olga Valverde & Tarek A. Samad & Bernard P. Roques & Emiliana Borrelli, 1997. "Absence of opiate rewarding effects in mice lacking dopamine D2 receptors," Nature, Nature, vol. 388(6642), pages 586-589, August.
    • Handle: RePEc:nat:nature:v:388:y:1997:i:6642:d:10.1038_41567
    DOI: 10.1038/41567
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    Cited by:

    1. Anna Grzywacz & Jolanta Chmielowiec & Krzysztof Chmielowiec & Bożena Mroczek & Jolanta Masiak & Aleksandra Suchanecka & Olimpia Sipak-Szmigiel & Kamila Szumilas & Grzegorz Trybek, 2019. "The Ankyrin Repeat and Kinase Domain Containing 1 Gene Polymorphism ( ANKK1 Taq1A ) and Personality Traits in Addicted Subjects," IJERPH, MDPI, vol. 16(15), pages 1-13, July.
    2. Anna Grzywacz & Aleksandra Suchanecka & Jolanta Chmielowiec & Krzysztof Chmielowiec & Kamila Szumilas & Jolanta Masiak & Łukasz Balwicki & Monika Michałowska-Sawczyn & Grzegorz Trybek, 2020. "Personality Traits or Genetic Determinants—Which Strongly Influences E-Cigarette Users?," IJERPH, MDPI, vol. 17(1), pages 1-15, January.

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