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Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)

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  • Poojitha Balakrishnan

    (Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY 10032, USA)

  • Miranda R. Jones

    (Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA)

  • Dhananjay Vaidya

    (Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA)

  • Maria Tellez-Plaza

    (Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Fundación de Investigación Hospital Clínico de Valencia INCLIVA, Valencia 46010, Spain)

  • Wendy S. Post

    (Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Department of Medicine, Johns Hopkins School of Medicine, Baltimore, MD 21205, USA)

  • Joel D. Kaufman

    (Department of Environmental and Occupational Health Sciences, University of Washington, Seattle, WA 98195, USA)

  • Suzette J. Bielinski

    (Department of Health Sciences Research, Mayo Clinic, Rochester, MN 55905, USA)

  • Kent Taylor

    (Los Angeles BioMedical Research Institute at Harbor-UCLA Medical Center, Los Angeles, CA 90502, USA)

  • Kevin Francesconi

    (Institute of Chemistry, University of Graz, 8010 Graz, Austria)

  • Walter Goessler

    (Institute of Chemistry, University of Graz, 8010 Graz, Austria)

  • Ana Navas-Acien

    (Department of Environmental Health Sciences, Columbia Mailman School of Public Health, New York, NY 10032, USA
    Department of Epidemiology, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA
    Department of Environmental Health Sciences, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD 21205, USA)

Abstract

We investigated the effect of candidate variants in AS3MT (arsenic (III) methyltransferase) with urinary arsenic metabolites and their principal components in a subset of 264 participants in the Multi-Ethnic Study of Atherosclerosis (MESA). Urinary arsenic species, including inorganic arsenic (iAs), monomethylarsonate (MMA), dimethylarsinate (DMA), and arsenobetaine (Ab), were measured using high performance liquid chromatography-inductively coupled plasma mass spectrometry (HPLC-ICPMS) and corrected for organic sources from seafood consumption by regressing Ab on arsenic species using a validated method. Principal components of arsenic metabolism were also used as independent phenotypes. We conducted linear regression of arsenic traits with allelic dosage of candidate single nucleotide polymorphisms (SNPs) rs12768205 (G > A), rs3740394 (A > G), and rs3740393 (G > C) measured using Illumina MetaboChip. Models were stratified by non-Hispanic white vs. all other race/ethnicity and adjusted for age, sex, arsenic exposure, study site, and population stratification. Consistent with previous studies, rs12768205 showed evidence for strongest association (non-Hispanic white: iAs% −0.14 (P 0.83), MMA% −0.66 (0.49), DMA% 0.81(0.49); other race/ethnicity: 0.13 (0.71), −1.21 (0.09), 1.08 (0.20)). No association, however, passed the strict Bonferroni p -value. This was a novel study among an ethnically diverse population exposed to low arsenic levels.

Suggested Citation

  • Poojitha Balakrishnan & Miranda R. Jones & Dhananjay Vaidya & Maria Tellez-Plaza & Wendy S. Post & Joel D. Kaufman & Suzette J. Bielinski & Kent Taylor & Kevin Francesconi & Walter Goessler & Ana Nava, 2018. "Ethnic, Geographic, and Genetic Differences in Arsenic Metabolism at Low Arsenic Exposure: A Preliminary Analysis in the Multi-Ethnic Study of Atherosclerosis (MESA)," IJERPH, MDPI, vol. 15(6), pages 1-11, June.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:6:p:1179-:d:150797
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    References listed on IDEAS

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    1. Bryan N Howie & Peter Donnelly & Jonathan Marchini, 2009. "A Flexible and Accurate Genotype Imputation Method for the Next Generation of Genome-Wide Association Studies," PLOS Genetics, Public Library of Science, vol. 5(6), pages 1-15, June.
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    Cited by:

    1. Humberto Parada & Tianying Wu & Rebecca C. Fry & Laura Farnan & Gary J. Smith & James L. Mohler & Jeannette T. Bensen, 2020. "Understanding the Relationship between Environmental Arsenic and Prostate Cancer Aggressiveness among African-American and European-American Men in North Carolina," IJERPH, MDPI, vol. 17(22), pages 1-13, November.

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