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Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy

Author

Listed:
  • Enrico Paci

    (INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy)

  • Daniela Pigini

    (INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy)

  • Lisa Bauleo

    (Lazio Regional Health Service, Department of Epidemiology, Via Cristoforo Colombo 112, 00147 Rome, Italy)

  • Carla Ancona

    (Lazio Regional Health Service, Department of Epidemiology, Via Cristoforo Colombo 112, 00147 Rome, Italy)

  • Francesco Forastiere

    (Lazio Regional Health Service, Department of Epidemiology, Via Cristoforo Colombo 112, 00147 Rome, Italy)

  • Giovanna Tranfo

    (INAIL, Department of Occupational and Environmental Medicine, Epidemiology and Hygiene, Via di Fontana Candida 1, Monteporzio Catone, 00078 Rome, Italy)

Abstract

Background: Urinary cotinine, a metabolite of nicotine, is a marker of tobacco smoke exposure. A cutoff value for cotinine concentration can be set to distinguish smokers from non-smokers, independently from self-declared status. Method: Cotinine was determined by isotopic dilution High Performance Liquid Chromatography coupled to tandem mass spectrometry (HPLC-MS/MS) between 2013 and 2014 on urine samples of a population of 1075 subjects. Results : 296 subjects have a cotinine level higher than 100 μg/g of creatinine (cutoff), with a median cotinine concentration of 1504.70 μg/g of creatinine. The mean is 27.5% of smokers and 60.5% in this group are females. The median value for non-smokers is 5.6 μg/g of creatinine. Two hundred and seventy-five subjects declared to be smokers in the questionnaire, but 6 (2.2%) present urinary cotinine levels lower than cutoff; 800 subjects declared to be non-smokers, but 26 of them presented urinary cotinine levels that were higher than the cutoff (3.3%). Conclusion: Using the cutoff of 100 μg/g, the misclassification of smokers resulted to be 2.2%, indicating that the selected value is suitable for studying the human exposures to environmental and occupational pollutants, including those produced by smoking.

Suggested Citation

  • Enrico Paci & Daniela Pigini & Lisa Bauleo & Carla Ancona & Francesco Forastiere & Giovanna Tranfo, 2018. "Urinary Cotinine Concentration and Self-Reported Smoking Status in 1075 Subjects Living in Central Italy," IJERPH, MDPI, vol. 15(4), pages 1-8, April.
    • Handle: RePEc:gam:jijerp:v:15:y:2018:i:4:p:804-:d:142104
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    References listed on IDEAS

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    1. Jin-Hyeong Kim & Juhwan Noh & Jae-Woo Choi & Eun-Cheol Park, 2017. "Association of Education and Smoking Status on Risk of Diabetes Mellitus: A Population-Based Nationwide Cross-Sectional Study," IJERPH, MDPI, vol. 14(6), pages 1-9, June.
    2. World Health Organization, 2015. "WHO report on the global tobacco epidemic, 2015: Raising taxes on tobacco," University of California at San Francisco, Center for Tobacco Control Research and Education qt1fh1f32m, Center for Tobacco Control Research and Education, UC San Francisco.
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    Cited by:

    1. Kijeong Lee & In Hak Choi & Hoyoung Lee & Soojeong Choi & Sang Hag Lee & Tae Hoon Kim, 2020. "Association of Cotinine-Verified Cigarette Exposure with Chronic Rhinosinusitis in Korean Adults," IJERPH, MDPI, vol. 17(21), pages 1-10, November.
    2. Giulia Paolocci & Lisa Bauleo & Ilenia Folletti & Nicola Murgia & Giacomo Muzi & Carla Ancona, 2020. "Industrial Air Pollution and Respiratory Health Status among Residents in an Industrial Area in Central Italy," IJERPH, MDPI, vol. 17(11), pages 1-13, May.
    3. Lubica Argalasova & Ingrid Zitnanova & Diana Vondrova & Monika Dvorakova & Lucia Laubertova & Jana Jurkovicova & Juraj Stofko & Michael Weitzman & Iveta Waczulikova & Martin Simko, 2019. "Self-Reported Exposure to ETS (Environmental Tobacco Smoke), Urinary Cotinine, and Oxidative Stress Parameters in Pregnant Women—The Pilot Study," IJERPH, MDPI, vol. 16(9), pages 1-14, May.

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