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New Immunotherapy Strategies in Breast Cancer

Author

Listed:
  • Lin-Yu Yu

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Jie Tang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Cong-Min Zhang

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Wen-Jing Zeng

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Han Yan

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Mu-Peng Li

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

  • Xiao-Ping Chen

    (Department of Clinical Pharmacology, Xiangya Hospital, Central South University, Changsha 410008, China
    Institute of Clinical Pharmacology, Central South University, Hunan Key Laboratory of Pharmacogenetics, Changsha 410078, China)

Abstract

Breast cancer is the most commonly diagnosed cancer among women. Therapeutic treatments for breast cancer generally include surgery, chemotherapy, radiotherapy, endocrinotherapy and molecular targeted therapy. With the development of molecular biology, immunology and pharmacogenomics, immunotherapy becomes a promising new field in breast cancer therapies. In this review, we discussed recent progress in breast cancer immunotherapy, including cancer vaccines, bispecific antibodies, and immune checkpoint inhibitors. Several additional immunotherapy modalities in early stages of development are also highlighted. It is believed that these new immunotherapeutic strategies will ultimately change the current status of breast cancer therapies.

Suggested Citation

  • Lin-Yu Yu & Jie Tang & Cong-Min Zhang & Wen-Jing Zeng & Han Yan & Mu-Peng Li & Xiao-Ping Chen, 2017. "New Immunotherapy Strategies in Breast Cancer," IJERPH, MDPI, vol. 14(1), pages 1-18, January.
    • Handle: RePEc:gam:jijerp:v:14:y:2017:i:1:p:68-:d:87618
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    References listed on IDEAS

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    1. Roy S. Herbst & Jean-Charles Soria & Marcin Kowanetz & Gregg D. Fine & Omid Hamid & Michael S. Gordon & Jeffery A. Sosman & David F. McDermott & John D. Powderly & Scott N. Gettinger & Holbrook E. K. , 2014. "Predictive correlates of response to the anti-PD-L1 antibody MPDL3280A in cancer patients," Nature, Nature, vol. 515(7528), pages 563-567, November.
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