IDEAS home Printed from https://ideas.repec.org/a/gam/jijerp/v13y2016i3p260-d64543.html
   My bibliography  Save this article

Polymorphisms in Four Genes ( KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China

Author

Listed:
  • Kaiping Gao

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China
    The authors contributed equally to this work)

  • Jinjin Wang

    (Department of Traditional Chinese Medicine Prevention, Preventive Medicine Research Evaluation Center, Henan University of Traditional Chinese Medicine, Zhengzhou 450001, China
    The authors contributed equally to this work)

  • Linlin Li

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Yujia Zhai

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Yongcheng Ren

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Haifei You

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Bingyuan Wang

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

  • Xuli Wu

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Jianna Li

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Zichen Liu

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Xiong Li

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Yaxin Huang

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Xin-Ping Luo

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Dongsheng Hu

    (Department of Preventive Medicine, School of Medicine, Shenzhen University, Shenzhen 518060, China)

  • Kinji Ohno

    (Division of Neurogenetics, Center for Neurological Diseases and Cancer, University Graduate School of Medicine, Nagoya 4668550, Japan)

  • Chongjian Wang

    (Department of Epidemiology, College of Public Health, Zhengzhou University, Zhengzhou 450001, China)

Abstract

Genetic variants at KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963 have been associated with type 2 diabetes mellitus (T2DM), but the results are contradictory in Chinese populations. The aim of the present study was to investigate the association of these four SNPs with T2DM in a large population of Han Chinese at Henan province, China. Seven-hundred-thirty-six patients with T2DM (cases) and Seven-hundred-sixty-eight healthy glucose-tolerant controls were genotyped for KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963. The association of genetic variants in these four genes with T2DM was analyzed using multivariate logistic regression. Genotypes and allele distributions of KCNQ1 rs151290 were significantly different between the cases and controls ( p < 0.05). The AC and CC genotypes and the combined AC + CC genotype of rs151290 in KCNQ1 were associated with increases risk of T2DM before (OR = 1.482, 95% CI = 1.062–2.069; p = 0.021; OR = 1.544, 95% CI = 1.097–2.172, p = 0.013; and OR = 1.509, 95% CI = 1.097–2.077, p = 0.011, respectively) and after (OR = 1.539, 95% CI = 1.015–2.332, p = 0.042; OR = 1.641, 95% CI = 1.070–2.516, p = 0.023; and OR = 1.582, 95% CI = 1.061–2.358, p = 0.024; respectively) adjustment for sex, age, anthropometric measurements, biochemical indexes, smoking and alcohol consumption. Consistent with results of genotype analysis, the C allele of rs151290 in KCNQ1 was also associated with increased risk of T2DM (OR = 1.166, 95% CI = 1.004–1.355, p = 0.045). No associations between genetic variants of KLF14 rs972283, GCKR rs780094 or MTNR1B rs10830963 and T2DM were detected. The AC and CC genotypes and the C allele of rs151290 in KCNQ1 may be risk factors for T2DM in Han Chinese in Henan province.

Suggested Citation

  • Kaiping Gao & Jinjin Wang & Linlin Li & Yujia Zhai & Yongcheng Ren & Haifei You & Bingyuan Wang & Xuli Wu & Jianna Li & Zichen Liu & Xiong Li & Yaxin Huang & Xin-Ping Luo & Dongsheng Hu & Kinji Ohno &, 2016. "Polymorphisms in Four Genes ( KCNQ1 rs151290, KLF14 rs972283, GCKR rs780094 and MTNR1B rs10830963) and Their Correlation with Type 2 Diabetes Mellitus in Han Chinese in Henan Province, China," IJERPH, MDPI, vol. 13(3), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:13:y:2016:i:3:p:260-:d:64543
    as

    Download full text from publisher

    File URL: https://www.mdpi.com/1660-4601/13/3/260/pdf
    Download Restriction: no
    File URL: https://www.mdpi.com/1660-4601/13/3/260/
    Download Restriction: no
    ---><---

    References listed on IDEAS

    as
    1. Claudia Ha Ting Tam & Janice Sin Ka Ho & Ying Wang & Heung Man Lee & Vincent Kwok Lim Lam & Soren Germer & Mitchell Martin & Wing Yee So & Ronald Ching Wan Ma & Juliana Chung Ngor Chan & Maggie Chor Y, 2010. "Common Polymorphisms in MTNR1B, G6PC2 and GCK Are Associated with Increased Fasting Plasma Glucose and Impaired Beta-Cell Function in Chinese Subjects," PLOS ONE, Public Library of Science, vol. 5(7), pages 1-8, July.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Hongyan Mao & Qin Li & Shujun Gao, 2012. "Meta-Analysis of the Relationship between Common Type 2 Diabetes Risk Gene Variants with Gestational Diabetes Mellitus," PLOS ONE, Public Library of Science, vol. 7(9), pages 1-7, September.
    2. Da Fu & Xianling Cong & Yushui Ma & Haidong Cai & Mingxiang Cai & Dan Li & Mingli Lv & Xueyu Yuan & Yinghui Huang & Zhongwei Lv, 2013. "Genetic Polymorphism of Glucokinase on the Risk of Type 2 Diabetes and Impaired Glucose Regulation: Evidence Based on 298, 468 Subjects," PLOS ONE, Public Library of Science, vol. 8(2), pages 1-8, February.
    3. Haoran Wang & Lei Liu & Jinzhao Zhao & Guanglin Cui & Chen Chen & Hu Ding & Dao Wen Wang, 2013. "Large Scale Meta-Analyses of Fasting Plasma Glucose Raising Variants in GCK, GCKR, MTNR1B and G6PC2 and Their Impacts on Type 2 Diabetes Mellitus Risk," PLOS ONE, Public Library of Science, vol. 8(6), pages 1-11, June.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:gam:jijerp:v:13:y:2016:i:3:p:260-:d:64543. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: MDPI Indexing Manager (email available below). General contact details of provider: https://www.mdpi.com .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.