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Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality

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  • Chung-Yen Lu

    (School of Post-Baccalaureate Chinese Medicine, China Medical University, Taichung 404, Taiwan
    Research Center for Traditional Chinese Medicine, China Medical University Hospital, Taichung 404, Taiwan)

  • Yee-Chung Ma

    (Institute of Environmental Health, National Taiwan University, Taipei 100, Taiwan)

  • Pei-Chun Chen

    (Institute of Epidemiology and Preventive Medicine, National Taiwan University, Taipei 100, Taiwan)

  • Chin-Ching Wu

    (Department of Public Health, China Medical University, Taichung 404, Taiwan)

  • Yi-Chun Chen

    (Department of Health Management, I-Shou University, Kaohsiung 824, Taiwan)

Abstract

Studies have used 8-hydroxydeoxyguanosine (8-OHdG) as a biomarker to detect systemic oxidative DNA damage associated with oxidative stress. However, studies on the association between exposure to tobacco smoking and urinary 8-OHdgG give inconsistent results. Limited studies have estimated the oxidative stress among office workers. This study assessed the association between urinary 8-OHdG and cotinine for office workers. Workers (389) including smokers, ex-smokers and non-smokers from 87 offices at high-rise buildings in Taipei participated in this study with informed consent. Each participant completed a questionnaire and provided a spot urine specimen at the end of work day for measuring urinary 8-OHdG and cotinine. The carbon dioxide (CO 2 ) levels in workers’ offices were also measured. The questionnaire reported socio-demographic characteristics, life styles and allergic history. The urinary 8-OHdG level increased with the cotinine level among participants (Spearmans’ rho = 0.543, p < 0.001). The mean of urinary 8-OHdG and cotinine was 5.81 ± 3.53 μg/g creatinine and 3.76 ± 4.06 μg/g creatinine, respectively. Comparing with non-smokers, the adjusted odds ratio (OR) of having urinary 8-OHdG greater than the median level of 4.99 μg/g creatinine was 5.30 (95% confidence intervals (CI) = 1.30–21.5) for current smokers and 0.91 (95% CI = 0.34–2.43) for former smokers. We also found workers exposed to 1,000 ppm of CO 2 at offices had an adjusted OR of 4.28 (95% CI = 1.12–16.4) to have urinary 8-OHdG greater than 4.99 μg/g creatinine, compared to those exposed to indoor CO 2 under 600 ppm. In conclusion, urinary 8-OHdG could represent a suitable marker for measuring smoking and CO 2 exposure for office workers.

Suggested Citation

  • Chung-Yen Lu & Yee-Chung Ma & Pei-Chun Chen & Chin-Ching Wu & Yi-Chun Chen, 2014. "Oxidative Stress of Office Workers Relevant to Tobacco Smoking and Inner Air Quality," IJERPH, MDPI, vol. 11(6), pages 1-12, May.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:6:p:5586-5597:d:36463
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    References listed on IDEAS

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    1. Taku Nagano & Makiko Shimizu & Kazuma Kiyotani & Tetsuya Kamataki & Ryohji Takano & Norie Murayama & Fumiaki Shono & Hiroshi Yamazaki, 2010. "Biomonitoring of Urinary Cotinine Concentrations Associated with Plasma Levels of Nicotine Metabolites after Daily Cigarette Smoking in a Male Japanese Population," IJERPH, MDPI, vol. 7(7), pages 1-12, July.
    2. Athanasios Valavanidis & Thomais Vlachogianni & Konstantinos Fiotakis, 2009. "Tobacco Smoke: Involvement of Reactive Oxygen Species and Stable Free Radicals in Mechanisms of Oxidative Damage, Carcinogenesis and Synergistic Effects with Other Respirable Particles," IJERPH, MDPI, vol. 6(2), pages 1-18, February.
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    Cited by:

    1. Chung-Yen Lu & Meng-Chuan Tsai & Chih-Hsin Muo & Yu-Hsien Kuo & Fung-Chang Sung & Chin-Ching Wu, 2017. "Personal, Psychosocial and Environmental Factors Related to Sick Building Syndrome in Official Employees of Taiwan," IJERPH, MDPI, vol. 15(1), pages 1-9, December.
    2. Ying-Yi Chen & Fung-Chang Sung & Mei-Lien Chen & I-Fang Mao & Chung-Yen Lu, 2016. "Indoor Air Quality in the Metro System in North Taiwan," IJERPH, MDPI, vol. 13(12), pages 1-10, December.

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