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Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B 1

Author

Listed:
  • Kejie Chen

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
    These authors contributed equally to this work.)

  • Xi Peng

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China
    These authors contributed equally to this work.)

  • Jing Fang

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Hengmin Cui

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Zhicai Zuo

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Junliang Deng

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Zhengli Chen

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Yi Geng

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Weimin Lai

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Li Tang

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

  • Qingqiu Yang

    (Department of Veterinary Medicine, Sichuan Agricultural University, Ya'an 625014, China)

Abstract

Aflatoxin B 1 (AFB 1 ), which causes hepatocellular carcinoma and immune-suppression, is commonly found in feedstuffs. To evaluate the ability of selenium (Se) to counteract the deleterious effects of AFB 1 , two hundred 1-day-old male avian broilers, divided into five groups, were fed with basal diet (control group), 0.3 mg/kg AFB 1 (AFB 1 group), 0.3 mg/kg AFB 1 +0.2 mg/kg Se (+Se group I), 0.3 mg/kg AFB 1 +0.4 mg/kg Se (+Se group II) and 0.3 mg/kg AFB 1 +0.6 mg/kg Se (+Se group III), respectively. Compared with control group, the relative weight of spleen in the AFB 1 group was decreased at 21 days of age. The relative weight of spleen in the three +Se groups was higher than that in the AFB 1 group. By pathological observation, the major spleen lesions included congestion in red pulp and vacuoles appeared in the lymphatic nodules and periarterial lymphatic sheath in the AFB 1 group. In +Se groups II and III, the incidence of major splenic lesions was decreased. The percentages of CD 3 + , CD 3 + CD 4 + and CD 3 + CD 8 + T cells in the AFB 1 group were lower than those in control group from 7 to 21 days of age, while there was a marked increase in the three +Se groups compared to the AFB 1 group. The results indicated that sodium selenite could improve the cellular immune function impaired by AFB 1 through increasing the relative weight of spleen and percentages of splenic T cell subsets, and alleviating histopathological spleen damage.

Suggested Citation

  • Kejie Chen & Xi Peng & Jing Fang & Hengmin Cui & Zhicai Zuo & Junliang Deng & Zhengli Chen & Yi Geng & Weimin Lai & Li Tang & Qingqiu Yang, 2014. "Effects of Dietary Selenium on Histopathological Changes and T Cells of Spleen in Broilers Exposed to Aflatoxin B 1," IJERPH, MDPI, vol. 11(2), pages 1-10, February.
    • Handle: RePEc:gam:jijerp:v:11:y:2014:i:2:p:1904-1913:d:32790
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    References listed on IDEAS

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    1. Fengyuan Wang & Gang Shu & Xi Peng & Jing Fang & Kejie Chen & Hengmin Cui & Zhengli Chen & Zhicai Zuo & Junliang Deng & Yi Geng & Weimin Lai, 2013. "Protective Effects of Sodium Selenite against Aflatoxin B 1 -Induced Oxidative Stress and Apoptosis in Broiler Spleen," IJERPH, MDPI, vol. 10(7), pages 1-11, July.
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    Cited by:

    1. Na Liang & Fengyuan Wang & Xi Peng & Jing Fang & Hengmin Cui & Zhengli Chen & Weimin Lai & Yi Zhou & Yi Geng, 2015. "Effect of Sodium Selenite on Pathological Changes and Renal Functions in Broilers Fed a Diet Containing Aflatoxin B 1," IJERPH, MDPI, vol. 12(9), pages 1-13, September.

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