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Placental Transfer of Persistent Organic Pollutants: A Preliminary Study on Mother-Newborn Pairs

Author

Listed:
  • Maria Grazia Porpora

    (Department of Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy)

  • Renato Lucchini

    (Perinatology and Childcare, "Sapienza" University Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy)

  • Annalisa Abballe

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Anna Maria Ingelido

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Silvia Valentini

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Eliana Fuggetta

    (Department of Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy)

  • Veronica Cardi

    (Department of Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy)

  • Adele Ticino

    (Department of Gynaecology, Obstetrics and Urology, "Sapienza" University of Rome, Policlinico Umberto I, Viale del Policlinico 155, 00161 Rome, Italy)

  • Valentina Marra

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Anna Rita Fulgenzi

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

  • Elena De Felip

    (Toxicological Chemistry Unit, Department of the Environment and Primary Prevention, Istituto Superiore di Sanità, Viale Regina Elena 299, 00161 Rome, Italy)

Abstract

The aim of this study was to characterize the placental transfer of some environmental pollutants, and to explore the possibility of quantitatively predicting in utero exposure to these contaminants from concentrations assessed in maternal blood. Levels of toxic substances such as pesticides ( p,p’ -DDE, β-HCH, and HCB), polychlorinated biphenyls (PCBs), perfluorooctane sulfonate (PFOS), and perfluorooctanoic acid (PFOA) were determined in serum samples of 38 pregnant women living in Rome and in samples of cord blood from their respective newborns. The study was carried out in the years 2008–2009. PCB mean concentrations in maternal serum and cord serum ranged from 0.058 to 0.30, and from 0.018 to 0.064 ng/g·fw respectively. Arithmetic means of PFOS and PFOA concentrations in mothers and newborns were 3.2 and 1.4 ng/g·fw, and 2.9 and 1.6 ng/g·fw. A strong correlation was observed between concentrations in the maternal and the foetal compartment for PFOS (Spearman r = 0.74, p < 0.001), PFOA (Spearman r = 0.70, p < 0.001), PCB 153 (Spearman r = 0.60, p < 0.001), HCB (Spearman r = 0.68, p < 0.001), PCB 180 (Spearman r = 0.55, p = 0.0012), and p,p’ -DDE (Spearman r = 0.53, p = 0.0099). A weak correlation (p < 0.1) was observed for PCBs 118 and 138.

Suggested Citation

  • Maria Grazia Porpora & Renato Lucchini & Annalisa Abballe & Anna Maria Ingelido & Silvia Valentini & Eliana Fuggetta & Veronica Cardi & Adele Ticino & Valentina Marra & Anna Rita Fulgenzi & Elena De F, 2013. "Placental Transfer of Persistent Organic Pollutants: A Preliminary Study on Mother-Newborn Pairs," IJERPH, MDPI, vol. 10(2), pages 1-13, February.
    • Handle: RePEc:gam:jijerp:v:10:y:2013:i:2:p:699-711:d:23517
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    Citations

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    Cited by:

    1. Gehui Wang & Jianjiang Lu & Zhenni Xing & Shanman Li & Zilong Liu & Yanbin Tong, 2017. "Occurrence, Distribution, and Risk Assessment of Perfluoroalkyl Acids (PFAAs) in Muscle and Liver of Cattle in Xinjiang, China," IJERPH, MDPI, vol. 14(9), pages 1-15, August.
    2. Yuhui Jiang & Yixuan Shang & Shuyao Yu & Jianguo Liu, 2018. "Dechlorination of Hexachlorobenzene in Contaminated Soils Using a Nanometallic Al/CaO Dispersion Mixture: Optimization through Response Surface Methodology," IJERPH, MDPI, vol. 15(5), pages 1-13, April.
    3. Zhenni Xing & Jianjiang Lu & Zilong Liu & Shanman Li & Gehui Wang & Xiaolong Wang, 2016. "Occurrence of Perfluorooctanoic Acid and Perfluorooctane Sulfonate in Milk and Yogurt and Their Risk Assessment," IJERPH, MDPI, vol. 13(10), pages 1-13, October.

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