IDEAS home Printed from https://ideas.repec.org/a/eee/tefoso/v161y2020ics0040162520311628.html
   My bibliography  Save this article

DIY Laboratories and business innovation ecosystems: The case of pharmaceutical industry

Author

Listed:
  • Wu, Qiang
  • He, Qile

Abstract

This paper conducts an embedded case study to verify a conceptual framework by which biopharma research in Do-It-Yourself (DIY) laboratories can be integrated into Research and Development (R&D) networks of the pharmaceutical industry. As an early attempt to extend the perspective of business innovation ecosystem into the research on DIY laboratories, this study reveals three major findings. First, DIY laboratories, contract research organizations (CROs) and pharmaceutical firms interdependently position and link with each other in an innovation ecosystem for new drug development. Second, through properly managing the issues of resource utilization and innovation appropriability, CROs play important hub and knowledge broker roles in coordinating and aligning different priorities and expectations of the key players in this innovation ecosystem. Third, this study maps and verifies two knowledge transfer models through which novel research findings in DIY laboratories can be converted into real commercial returns.

Suggested Citation

  • Wu, Qiang & He, Qile, 2020. "DIY Laboratories and business innovation ecosystems: The case of pharmaceutical industry," Technological Forecasting and Social Change, Elsevier, vol. 161(C).
    • Handle: RePEc:eee:tefoso:v:161:y:2020:i:c:s0040162520311628
    DOI: 10.1016/j.techfore.2020.120336
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0040162520311628
    Download Restriction: Full text for ScienceDirect subscribers only
    File URL: https://libkey.io/10.1016/j.techfore.2020.120336?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Jamal Azzam & Cécile Ayerbe & Rani Jeanne Dang, 2016. "Using patents to orchestrate ecosystem stability : the case of a french aerospace company," Post-Print halshs-01295810, HAL.
    2. Oliver Gassmann & Alexander Schuhmacher & Max von Zedtwitz & Gerrit Reepmeyer, 2018. "Leading Pharmaceutical Innovation," Springer Books, Springer, edition 3, number 978-3-319-66833-8, April.
    3. Rajagopal, 2014. "The Human Factors," Palgrave Macmillan Books, in: Architecting Enterprise, chapter 9, pages 225-249, Palgrave Macmillan.
    4. Styhre, Alexander, 2011. "Institutionalizing technoscience: Post-genomic technologies and the case of systems biology," Scandinavian Journal of Management, Elsevier, vol. 27(4), pages 375-388.
    5. Bonaccorsi, Andrea & Vargas, Juan, 2010. "Proliferation dynamics in new sciences," Research Policy, Elsevier, vol. 39(8), pages 1034-1050, October.
    6. Morgan Meyer, 2013. "Domesticating and democratizing science: a geography of do-it-yourself biology," CSI Working Papers Series 032, Centre de Sociologie de l'Innovation (CSI), Mines ParisTech.
    7. Coccia, Mario & Wang, Lili, 2015. "Path-breaking directions of nanotechnology-based chemotherapy and molecular cancer therapy," Technological Forecasting and Social Change, Elsevier, vol. 94(C), pages 155-169.
    8. Fox, Stephen, 2014. "Third Wave Do-It-Yourself (DIY): Potential for prosumption, innovation, and entrepreneurship by local populations in regions without industrial manufacturing infrastructure," Technology in Society, Elsevier, vol. 39(C), pages 18-30.
    9. Antti Pellinen & Paavo Ritala & Kati Järvi & Liisa-Maija Sainio, 2012. "Taking initiative in market creation - a business ecosystem actor perspective," International Journal of Business Environment, Inderscience Enterprises Ltd, vol. 5(2), pages 140-158.
    10. Hassanzadeh, Farhad & Modarres, Mohammad & Nemati, Hamid R. & Amoako-Gyampah, Kwasi, 2014. "A robust R&D project portfolio optimization model for pharmaceutical contract research organizations," International Journal of Production Economics, Elsevier, vol. 158(C), pages 18-27.
    11. Sarpong, David & Ofosu, George & Botchie, David & Clear, Fintan, 2020. "Do-it-yourself (DiY) science: The proliferation, relevance and concerns," Technological Forecasting and Social Change, Elsevier, vol. 158(C).
    12. Jamal Azzam & Cécile Ayerbe & Rani Jeanne Dang, 2016. "Using patents to orchestrate ecosystem stability : the case of a french aerospace company," Post-Print halshs-01295810, HAL.
    13. Hossain, Mokter, 2018. "Grassroots innovation: The state of the art and future perspectives," Technology in Society, Elsevier, vol. 55(C), pages 63-69.
    14. Franco Malerba & Luigi Orsenigo, 2015. "The evolution of the pharmaceutical industry," Business History, Taylor & Francis Journals, vol. 57(5), pages 664-687, July.
    15. Michael G. Jacobides & Carmelo Cennamo & Annabelle Gawer, 2018. "Towards a theory of ecosystems," Strategic Management Journal, Wiley Blackwell, vol. 39(8), pages 2255-2276, August.
    16. Sabatier, Valerie & Craig-Kennard, Adrienne & Mangematin, Vincent, 2012. "When technological discontinuities and disruptive business models challenge dominant industry logics: Insights from the drugs industry," Technological Forecasting and Social Change, Elsevier, vol. 79(5), pages 949-962.
    17. Lauto, Giancarlo & Valentin, Finn, 2016. "The knowledge production model of the New Sciences: The case of Translational Medicine," Technological Forecasting and Social Change, Elsevier, vol. 111(C), pages 12-21.
    18. Valérie Sabatier & Adrienne Kennard & Vincent Mangematin, 2012. "When technological discontinuities and disruptive business models challenge dominant industry logics: insights from the drugs industry," Grenoble Ecole de Management (Post-Print) hal-00658727, HAL.
    19. Valérie Sabatier & Adrienne Kennard & Vincent Mangematin, 2012. "When technological discontinuities and disruptive business models challenge dominant industry logics: insights from the drugs industry," Post-Print hal-00658727, HAL.
    20. Stilgoe, Jack & Owen, Richard & Macnaghten, Phil, 2013. "Developing a framework for responsible innovation," Research Policy, Elsevier, vol. 42(9), pages 1568-1580.
    21. Mariano Fressoli & Elisa Arond & Dinesh Abrol & Adrian Smith & Adrian Ely & Rafael Dias, 2014. "When grassroots innovation movements encounter mainstream institutions: implications for models of inclusive innovation," Innovation and Development, Taylor & Francis Journals, vol. 4(2), pages 277-292, October.
    22. Tierney, Robert & Hermina, Wahid & Walsh, Steven, 2013. "The pharmaceutical technology landscape: A new form of technology roadmapping," Technological Forecasting and Social Change, Elsevier, vol. 80(2), pages 194-211.
    23. Shasha Zhao & Hui Tan & Marina Papanastassiou & Anne-Wil Harzing, 2020. "The internationalization of innovation towards the South: A historical case study of a global pharmaceutical corporation in China (1993–2017)," Asia Pacific Journal of Management, Springer, vol. 37(2), pages 553-585, June.
    24. Joseph A. DiMasi & Henry G. Grabowski, 2007. "The cost of biopharmaceutical R&D: is biotech different?," Managerial and Decision Economics, John Wiley & Sons, Ltd., vol. 28(4-5), pages 469-479.
    25. Björn Johnson & Allan Dahl Andersen (ed.), 2012. "Learning, Innovation and Inclusive Development," Globelics Thematic Reviews, Globelics - Global Network for Economics of Learning, Innovation, and Competence Building Systems, Aalborg University, Department of Business and Management, number lics, September.
    26. de Alcantara, Douglas Pedro & Martens, Mauro Luiz, 2019. "Technology Roadmapping (TRM): a systematic review of the literature focusing on models," Technological Forecasting and Social Change, Elsevier, vol. 138(C), pages 127-138.
    27. Ranjay Gulati & Phanish Puranam & Michael Tushman, 2012. "Meta‐organization design: Rethinking design in interorganizational and community contexts," Strategic Management Journal, Wiley Blackwell, vol. 33(6), pages 571-586, June.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Heyen, Nils B. & Zenker, Andrea & Aichinger, Heike & Bratan, Tanja & Kaufmann, Tanja & Schnabl, Esther, 2024. "Innovation without growth? Exploring the (in)dependency of innovation on economic growth," Discussion Papers "Innovation Systems and Policy Analysis" 83, Fraunhofer Institute for Systems and Innovation Research (ISI).
    2. Qiu, Yixin & Bouncken, Ricarda B. & Arndt, Félix & Ng, Wilson, 2023. "Microfoundations and dynamics of do-it-yourself ecosystems," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    3. Andrei G. Shelomentsev & Kseniya S. Goncharova & Igor M. Stepnov & Julia A. Kovalchuk & Do Huong Lan & Roman S. Golov, 2021. "Strategic Innovation as a Factor of Adaptation of National Economies to the Development of Global Value Chains," Sustainability, MDPI, vol. 13(17), pages 1-27, August.
    4. Bouncken, Ricarda B. & Qiu, Yixin & García, F. Javier Sendra, 2021. "Flexible pattern matching approach: Suggestions for augmenting theory evolvement," Technological Forecasting and Social Change, Elsevier, vol. 167(C).
    5. Miozza, Mario & Brunetta, Federica & Appio, Francesco Paolo, 2024. "Digital transformation of the Pharmaceutical Industry: A future research agenda for management studies," Technological Forecasting and Social Change, Elsevier, vol. 207(C).
    6. Carla Irissarry & Thierry Burger-Helmchen, 2024. "Using Artificial Intelligence to Advance the Research and Development of Orphan Drugs," Businesses, MDPI, vol. 4(3), pages 1-20, September.
    7. Yuan, Ning & Li, Meijuan, 2024. "Research on collaborative innovation behavior of enterprise innovation ecosystem under evolutionary game," Technological Forecasting and Social Change, Elsevier, vol. 206(C).

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Lauto, Giancarlo & Valentin, Finn, 2016. "The knowledge production model of the New Sciences: The case of Translational Medicine," Technological Forecasting and Social Change, Elsevier, vol. 111(C), pages 12-21.
    2. Kajikawa, Yuya & Mejia, Cristian & Wu, Mengjia & Zhang, Yi, 2022. "Academic landscape of Technological Forecasting and Social Change through citation network and topic analyses," Technological Forecasting and Social Change, Elsevier, vol. 182(C).
    3. Shen, Lei & Shi, Qingyue & Parida, Vinit & Jovanovic, Marin, 2024. "Ecosystem orchestration practices for industrial firms: A qualitative meta-analysis, framework development and research agenda," Journal of Business Research, Elsevier, vol. 173(C).
    4. Chammassian, Raffi Gabriel & Sabatier, Valerie, 2020. "The role of costs in business model design for early-stage technology startups," Technological Forecasting and Social Change, Elsevier, vol. 157(C).
    5. von Delft, Stephan & Zhao, Yang, 2021. "Business models in process industries: Emerging trends and future research," Technovation, Elsevier, vol. 105(C).
    6. Michael G. Jacobides & Carmelo Cennamo & Annabelle Gawer, 2018. "Towards a theory of ecosystems," Strategic Management Journal, Wiley Blackwell, vol. 39(8), pages 2255-2276, August.
    7. Swen Nadkarni & Reinhard Prügl, 2021. "Digital transformation: a review, synthesis and opportunities for future research," Management Review Quarterly, Springer, vol. 71(2), pages 233-341, April.
    8. David A Brown & Nelson Ma & Jin Sug Yang & Nicole Sutton & Gillian McAllister & Deborah Parker & Olivia Rawlings-Way & Rachael L Lewis, 2023. "The impact of business model workforce configurations on value creation and value appropriation in the Australian aged care sector," Australian Journal of Management, Australian School of Business, vol. 48(3), pages 495-523, August.
    9. Lehoux, P. & Daudelin, G. & Williams-Jones, B. & Denis, J.-L. & Longo, C., 2014. "How do business model and health technology design influence each other? Insights from a longitudinal case study of three academic spin-offs," Research Policy, Elsevier, vol. 43(6), pages 1025-1038.
    10. Engwall, Mats & Kaulio, Matti & Karakaya, Emrah & Miterev, Maxim & Berlin, Daniel, 2021. "Experimental networks for business model innovation: A way for incumbents to navigate sustainability transitions?," Technovation, Elsevier, vol. 108(C).
    11. Taewon Suh & Omar J. Khan & Benedikt Schnellbächer & Sven Heidenreich, 2019. "Strategic Accord And Tension For Business Model Innovation: Examining Different Tacit Knowledge Types And Open Action Strategies," International Journal of Innovation Management (ijim), World Scientific Publishing Co. Pte. Ltd., vol. 24(04), pages 1-29, July.
    12. Betz, Ulrich A.K. & Betz, Frederick & Kim, Rachel & Monks, Brendan & Phillips, Fred, 2019. "Surveying the future of science, technology and business – A 35 year perspective," Technological Forecasting and Social Change, Elsevier, vol. 144(C), pages 137-147.
    13. Jin, Byoungho Ellie & Shin, Daeun Chloe, 2020. "Changing the game to compete: Innovations in the fashion retail industry from the disruptive business model," Business Horizons, Elsevier, vol. 63(3), pages 301-311.
    14. Melanie Bryant & Vaughan Higgins, 2019. "Managing the grand challenge of biological threats to food production: The importance of institutional logics for managing Australian biosecurity," Australian Journal of Management, Australian School of Business, vol. 44(4), pages 534-550, November.
    15. Isabelle Leroux & Paul Muller & Béatrice Plottu & Caroline Widehem, 2014. "Evolution of business models in French ?Pôles de compétitivité?: the role of intermediaries in horticultural varietal creation," ERSA conference papers ersa14p693, European Regional Science Association.
    16. Rezaee Vessal, Saeedeh & Partouche-Sebban, Judith & Scuotto, Veronica & Maalaoui, Adnane, 2021. "Overcoming stressful life events at do-it-yourself (DIY) laboratories. A new trailblazing career for disadvantaged entrepreneurs," Technological Forecasting and Social Change, Elsevier, vol. 164(C).
    17. Okpalaoka, Chijindu Iheanacho, 2023. "Research on the digital economy: Developing trends and future directions," Technological Forecasting and Social Change, Elsevier, vol. 193(C).
    18. Rayna, Thierry & Striukova, Ludmila, 2016. "From rapid prototyping to home fabrication: How 3D printing is changing business model innovation," Technological Forecasting and Social Change, Elsevier, vol. 102(C), pages 214-224.
    19. Belussi, Fiorenza & Orsi, Luigi & Savarese, Maria, 2019. "Mapping Business Model Research: A Document Bibliometric Analysis," Scandinavian Journal of Management, Elsevier, vol. 35(3).
    20. Pronker, Esther & Weenen, Tamar & Commandeur, Harry & Claassen, E. & Osterhaus, A.D.M.E., 2015. "Scratching the surface: Exploratory analysis of key opinion leaders on rate limiting factors in novel adjuvanted-vaccine development," Technological Forecasting and Social Change, Elsevier, vol. 90(PB), pages 420-432.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:tefoso:v:161:y:2020:i:c:s0040162520311628. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.sciencedirect.com/science/journal/00401625 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.