IDEAS home Printed from https://ideas.repec.org/a/eee/tefoso/v128y2018icp133-143.html
   My bibliography  Save this article

Institutionalisation of markets: The case of personalised cancer medicine in the Netherlands

Author

Listed:
  • Moors, Ellen H.M.
  • Kukk Fischer, Piret
  • Boon, Wouter P.C.
  • Schellen, Frank
  • Negro, Simona O.

Abstract

The article aims to understand the institutionalisation process of markets for innovative products. To pursue this study of market formation, we analysed the introduction of innovative personalised medicines products: Herceptin® (trastuzumab) for breast cancer and Tarceva® (erlotinib) for lung cancer, which were introduced successively in the Netherlands between 2000 and 2012. We apply the technological innovation system (TIS) approach to understand the development, implementation and diffusion of new markets, including new roles for users and producers, new forms of regulation and novel user practices regarding innovative health technologies. We show that market access became institutionalised as part of the technological innovation system of the first-mover personalised medicine, i.e. the market was formed, paving the way for the later personalised medicine products.

Suggested Citation

  • Moors, Ellen H.M. & Kukk Fischer, Piret & Boon, Wouter P.C. & Schellen, Frank & Negro, Simona O., 2018. "Institutionalisation of markets: The case of personalised cancer medicine in the Netherlands," Technological Forecasting and Social Change, Elsevier, vol. 128(C), pages 133-143.
  • Handle: RePEc:eee:tefoso:v:128:y:2018:i:c:p:133-143
    DOI: 10.1016/j.techfore.2017.11.011
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0040162517315652
    Download Restriction: Full text for ScienceDirect subscribers only

    File URL: https://libkey.io/10.1016/j.techfore.2017.11.011?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Andrea Mantovani & Francisco Ruiz-Aliseda, 2016. "Equilibrium Innovation Ecosystems: The Dark Side of Collaborating with Complementors," Management Science, INFORMS, vol. 62(2), pages 534-549, February.
    2. Edler, Jakob & Georghiou, Luke, 2007. "Public procurement and innovation--Resurrecting the demand side," Research Policy, Elsevier, vol. 36(7), pages 949-963, September.
    3. Negro, Simona O. & Hekkert, Marko P. & Smits, Ruud E., 2007. "Explaining the failure of the Dutch innovation system for biomass digestion--A functional analysis," Energy Policy, Elsevier, vol. 35(2), pages 925-938, February.
    4. Andrew H. Van de Ven & Marshall Scott Poole, 1990. "Methods for Studying Innovation Development in the Minnesota Innovation Research Program," Organization Science, INFORMS, vol. 1(3), pages 313-335, August.
    5. Wieczorek, Anna J. & Negro, Simona O. & Harmsen, Robert & Heimeriks, Gaston J. & Luo, Lin & Hekkert, Marko P., 2013. "A review of the European offshore wind innovation system," Renewable and Sustainable Energy Reviews, Elsevier, vol. 26(C), pages 294-306.
    6. Swan, Jacky & Goussevskaia, Anna & Newell, Sue & Robertson, Maxine & Bresnen, Mike & Obembe, Ademola, 2007. "Modes of organizing biomedical innovation in the UK and US and the role of integrative and relational capabilities," Research Policy, Elsevier, vol. 36(4), pages 529-547, May.
    7. Neij, Lena & Heiskanen, Eva & Strupeit, Lars, 2017. "The deployment of new energy technologies and the need for local learning," Energy Policy, Elsevier, vol. 101(C), pages 274-283.
    8. Boon, Wouter P.C. & Moors, Ellen H.M. & Meijer, Albert J., 2014. "Exploring dynamics and strategies of niche protection," Research Policy, Elsevier, vol. 43(4), pages 792-803.
    9. Lars Coenen & Bernhard Truffer, 2012. "Places and Spaces of Sustainability Transitions: Geographical Contributions to an Emerging Research and Policy Field," European Planning Studies, Taylor & Francis Journals, vol. 20(3), pages 367-374, March.
    10. Binz, Christian & Truffer, Bernhard & Coenen, Lars, 2014. "Why space matters in technological innovation systems—Mapping global knowledge dynamics of membrane bioreactor technology," Research Policy, Elsevier, vol. 43(1), pages 138-155.
    11. Carlsson, B & Stankiewicz, R, 1991. "On the Nature, Function and Composition of Technological Systems," Journal of Evolutionary Economics, Springer, vol. 1(2), pages 93-118, April.
    12. Michael Drummond & Adrian Towse, 2014. "Orphan drugs policies: a suitable case for treatment," The European Journal of Health Economics, Springer;Deutsche Gesellschaft für Gesundheitsökonomie (DGGÖ), vol. 15(4), pages 335-340, May.
    13. Morlacchi, Piera & Nelson, Richard R., 2011. "How medical practice evolves: Learning to treat failing hearts with an implantable device," Research Policy, Elsevier, vol. 40(4), pages 511-525, May.
    14. Markard, Jochen & Truffer, Bernhard, 2008. "Technological innovation systems and the multi-level perspective: Towards an integrated framework," Research Policy, Elsevier, vol. 37(4), pages 596-615, May.
    15. Farla, Jacco & Markard, Jochen & Raven, Rob & Coenen, Lars, 2012. "Sustainability transitions in the making: A closer look at actors, strategies and resources," Technological Forecasting and Social Change, Elsevier, vol. 79(6), pages 991-998.
    16. Metcalfe, J.S. & James, Andrew & Mina, Andrea, 2005. "Emergent innovation systems and the delivery of clinical services: The case of intra-ocular lenses," Research Policy, Elsevier, vol. 34(9), pages 1283-1304, November.
    17. Bergek, Anna & Jacobsson, Staffan & Carlsson, Bo & Lindmark, Sven & Rickne, Annika, 2008. "Analyzing the functional dynamics of technological innovation systems: A scheme of analysis," Research Policy, Elsevier, vol. 37(3), pages 407-429, April.
    18. Nelson, Richard R. & Buterbaugh, Kristin & Perl, Marcel & Gelijns, Annetine, 2011. "How medical know-how progresses," Research Policy, Elsevier, vol. 40(10), pages 1339-1344.
    19. Staffan Jacobsson & Anna Bergek, 2004. "Transforming the energy sector: the evolution of technological systems in renewable energy technology," Industrial and Corporate Change, Oxford University Press and the Associazione ICC, vol. 13(5), pages 815-849, October.
    20. Poole, Marshall Scott & Van de Ven, Andrew H. & Dooley, Kevin & Holmes, Michael E., 2000. "Organizational Change and Innovation Processes: Theory and Methods for Research," OUP Catalogue, Oxford University Press, number 9780195131987.
    21. Roy R. Kloet & Laurens K. Hessels & Marjolein B.M. Zweekhorst & Jacqueline E.W. Broerse & Tjard de Cock Buning, 2012. "Understanding Constraints in the Dynamics of a Research Programme Intended as a Niche Innovation," Science and Public Policy, Oxford University Press, vol. 40(2), pages 206-218, December.
    22. Kor Grit & Wilfred Dolfsma, 2002. "The Dynamics of the Dutch Health Care System--A Discourse Analysis," Review of Social Economy, Taylor & Francis Journals, vol. 60(3), pages 377-401.
    23. Ulrich Dewald & Bernhard Truffer, 2011. "Market Formation in Technological Innovation Systems—Diffusion of Photovoltaic Applications in Germany," Industry and Innovation, Taylor & Francis Journals, vol. 18(3), pages 285-300.
    Full references (including those not matched with items on IDEAS)

    Citations

    Citations are extracted by the CitEc Project, subscribe to its RSS feed for this item.
    as


    Cited by:

    1. Mendoza, Mario A. & Rodriguez Alfonso, Mauricio & Lhuillery, Stephane, 2021. "A battle of drones: Utilizing legitimacy strategies for the transfer and diffusion of dual-use technologies," Technological Forecasting and Social Change, Elsevier, vol. 166(C).
    2. Robinson, Douglas K.R. & Lagnau, Axel & Boon, Wouter P.C., 2019. "Innovation pathways in additive manufacturing: Methods for tracing emerging and branching paths from rapid prototyping to alternative applications," Technological Forecasting and Social Change, Elsevier, vol. 146(C), pages 733-750.
    3. Dedehayir, Ozgur & Mäkinen, Saku J. & Ortt, J. Roland, 2022. "Innovation ecosystems as structures: Actor roles, timing of their entrance, and interactions," Technological Forecasting and Social Change, Elsevier, vol. 183(C).
    4. Essen, Anna & Frishammar, Johan & Cenamor, Javier, 2023. "Entering non-platformized sectors: The Co-evolution of legitimacy debates and platform business models in digital health care," Technovation, Elsevier, vol. 121(C).
    5. Temina, Olga & Zvonareva, Olga & Horstman, Klasien, 2023. "Patients' work and fluid trajectories: Access to medicines for oncological and rare diseases in Russia," Social Science & Medicine, Elsevier, vol. 317(C).
    6. Alexander Flaig & Daniel Kindström & Mikael Ottosson, 2021. "Market-shaping phases—a qualitative meta-analysis and conceptual framework," AMS Review, Springer;Academy of Marketing Science, vol. 11(3), pages 354-374, December.
    7. Denicolai, Stefano & Previtali, Pietro, 2020. "Precision Medicine: Implications for value chains and business models in life sciences," Technological Forecasting and Social Change, Elsevier, vol. 151(C).
    8. Rezaee Vessal, Saeedeh & Partouche-Sebban, Judith & Scuotto, Veronica & Maalaoui, Adnane, 2021. "Overcoming stressful life events at do-it-yourself (DIY) laboratories. A new trailblazing career for disadvantaged entrepreneurs," Technological Forecasting and Social Change, Elsevier, vol. 164(C).
    9. T. Nampitch & Ieva Ubarte & Ingrida Vetloviene & Darius Skirmantas, 2020. "Intelligent Tutoring System for the Impact Analysis and Assessment of Online Ads and Intuitive Online Ad Serving," International Journal of Technology and Engineering Studies, PROF.IR.DR.Mohid Jailani Mohd Nor, vol. 6(1), pages 16-22.

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Kukk, Piret & Moors, Ellen H.M. & Hekkert, Marko P., 2016. "Institutional power play in innovation systems: The case of Herceptin®," Research Policy, Elsevier, vol. 45(8), pages 1558-1569.
    2. De Oliveira, Luiz Gustavo Silva & Negro, Simona O., 2019. "Contextual structures and interaction dynamics in the Brazilian Biogas Innovation System," Renewable and Sustainable Energy Reviews, Elsevier, vol. 107(C), pages 462-481.
    3. Haley, Brendan, 2018. "Integrating structural tensions into technological innovation systems analysis: Application to the case of transmission interconnections and renewable electricity in Nova Scotia, Canada," Research Policy, Elsevier, vol. 47(6), pages 1147-1160.
    4. Markard, Jochen & Raven, Rob & Truffer, Bernhard, 2012. "Sustainability transitions: An emerging field of research and its prospects," Research Policy, Elsevier, vol. 41(6), pages 955-967.
    5. Konstantinos Karanasios & Paul Parker, 2018. "Explaining the Diffusion of Renewable Electricity Technologies in Canadian Remote Indigenous Communities through the Technological Innovation System Approach," Sustainability, MDPI, vol. 10(11), pages 1-28, October.
    6. del Río, Pablo & Bleda, Mercedes, 2012. "Comparing the innovation effects of support schemes for renewable electricity technologies: A function of innovation approach," Energy Policy, Elsevier, vol. 50(C), pages 272-282.
    7. Coenen, Lars & Benneworth, Paul & Truffer, Bernhard, 2012. "Toward a spatial perspective on sustainability transitions," Research Policy, Elsevier, vol. 41(6), pages 968-979.
    8. Edsand, Hans, 2016. "Technological Innovation Systems and the wider context: A framework for developing countries," MERIT Working Papers 2016-017, United Nations University - Maastricht Economic and Social Research Institute on Innovation and Technology (MERIT).
    9. Bleda, Mercedes & del Río, Pablo, 2013. "The market failure and the systemic failure rationales in technological innovation systems," Research Policy, Elsevier, vol. 42(5), pages 1039-1052.
    10. Stephan, Annegret & Schmidt, Tobias S. & Bening, Catharina R. & Hoffmann, Volker H., 2017. "The sectoral configuration of technological innovation systems: Patterns of knowledge development and diffusion in the lithium-ion battery technology in Japan," Research Policy, Elsevier, vol. 46(4), pages 709-723.
    11. Dahesh, Mehran Badin & Tabarsa, Gholamali & Zandieh, Mostafa & Hamidizadeh, Mohammadreza, 2020. "Reviewing the intellectual structure and evolution of the innovation systems approach: A social network analysis," Technology in Society, Elsevier, vol. 63(C).
    12. Andersson, Johnn & Hellsmark, Hans & Sandén, Björn A., 2018. "Shaping factors in the emergence of technological innovations: The case of tidal kite technology," Technological Forecasting and Social Change, Elsevier, vol. 132(C), pages 191-208.
    13. Ayrapetyan, David & Befort, Nicolas & Hermans, Frans, 2025. "From local markets to global legitimacy: A materialization perspective on technological innovation system's dynamics," EconStor Open Access Articles and Book Chapters, ZBW - Leibniz Information Centre for Economics, vol. 54(1).
    14. Markard, Jochen, 2020. "The life cycle of technological innovation systems," Technological Forecasting and Social Change, Elsevier, vol. 153(C).
    15. Edsand, Hans-Erik, 2019. "Technological innovation system and the wider context: A framework for developing countries," Technology in Society, Elsevier, vol. 58(C).
    16. Jonas Heiberg & Bernhard Truffer, 2021. "The emergence of a global innovation system – a case study from the water sector," GEIST - Geography of Innovation and Sustainability Transitions 2021(09), GEIST Working Paper Series.
    17. Markard, Jochen & Hoffmann, Volker H., 2016. "Analysis of complementarities: Framework and examples from the energy transition," Technological Forecasting and Social Change, Elsevier, vol. 111(C), pages 63-75.
    18. Jacobsson, Staffan & Karltorp, Kersti, 2013. "Mechanisms blocking the dynamics of the European offshore wind energy innovation system – Challenges for policy intervention," Energy Policy, Elsevier, vol. 63(C), pages 1182-1195.
    19. van Alphen, Klaas & van Ruijven, Jochem & Kasa, Sjur & Hekkert, Marko & Turkenburg, Wim, 2009. "The performance of the Norwegian carbon dioxide, capture and storage innovation system," Energy Policy, Elsevier, vol. 37(1), pages 43-55, January.
    20. Hellsmark, Hans & Jacobsson, Staffan, 2009. "Opportunities for and limits to Academics as System builders--The case of realizing the potential of gasified biomass in Austria," Energy Policy, Elsevier, vol. 37(12), pages 5597-5611, December.

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:tefoso:v:128:y:2018:i:c:p:133-143. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.sciencedirect.com/science/journal/00401625 .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.