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An adaptive design for clinical trials with non-dichotomous response and prognostic factors

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  • Moler, José A.
  • Plo, Fernando
  • San Miguel, Miguel

Abstract

We present an adaptive design for multi-arm clinical trials with bounded response and prognostic factors. The allocation is ruled by an urn model that fits a Robbins-Monro scheme. We obtain asymptotic properties for the performance and allocation of treatments.

Suggested Citation

  • Moler, José A. & Plo, Fernando & San Miguel, Miguel, 2006. "An adaptive design for clinical trials with non-dichotomous response and prognostic factors," Statistics & Probability Letters, Elsevier, vol. 76(17), pages 1940-1946, November.
    • Handle: RePEc:eee:stapro:v:76:y:2006:i:17:p:1940-1946
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    References listed on IDEAS

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    1. Bai, Z. D. & Hu, Feifang & Shen, Liang, 2002. "An Adaptive Design for Multi-Arm Clinical Trials," Journal of Multivariate Analysis, Elsevier, vol. 81(1), pages 1-18, April.
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