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Phase transitions may explain why SARS-CoV-2 spreads so fast and why new variants are spreading faster

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  • Phillips, J.C.
  • Moret, Marcelo A.
  • Zebende, Gilney F.
  • Chow, Carson C.

Abstract

The novel coronavirus SARS CoV-2 responsible for the COVID-19 pandemic and SARS CoV-1 responsible for the SARS epidemic of 2002-2003 share an ancestor yet evolved to have much different transmissibility and global impact 1. A previously developed thermodynamic model of protein conformations hypothesized that SARS CoV-2 is very close to a new thermodynamic critical point, which makes it highly infectious but also easily displaced by a spike-based vaccine because there is a tradeoff between transmissibility and robustness 2. The model identified a small cluster of four key mutations of SARS CoV-2 that predicts much stronger viral attachment and viral spreading compared to SARS CoV-1. Here we apply the model to the SARS-CoV-2 variants Alpha (B.1.1.7), Beta (B.1.351), Gamma (P.1) and Delta (B.1.617.2)3 and predict, using no free parameters, how the new mutations will not diminish the effectiveness of current spike based vaccines and may even further enhance infectiousness by augmenting the binding ability of the virus.

Suggested Citation

  • Phillips, J.C. & Moret, Marcelo A. & Zebende, Gilney F. & Chow, Carson C., 2022. "Phase transitions may explain why SARS-CoV-2 spreads so fast and why new variants are spreading faster," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 598(C).
    • Handle: RePEc:eee:phsmap:v:598:y:2022:i:c:s0378437122002576
    DOI: 10.1016/j.physa.2022.127318
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    References listed on IDEAS

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    1. Phillips, J.C., 2021. "Synchronized attachment and the Darwinian evolution of coronaviruses CoV-1 and CoV-2," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 581(C).
    2. Phillips, J.C., 2014. "Fractals and self-organized criticality in proteins," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 415(C), pages 440-448.
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    Cited by:

    1. Hernane Pereira & Ludmilla Monfort Oliveira Sousa & Maíra Lima Souza & Thiago B. Murari & Marcelo A. Moret, 2024. "Overview of the initial phase of scientific production on COVID-19 during the pandemic," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 97(7), pages 1-11, July.
    2. Marcelo A. Moret & James C. Phillips, 2024. "Why and how did the COVID pandemic end abruptly?," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 97(8), pages 1-4, August.

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