IDEAS home Printed from https://ideas.repec.org/a/eee/phsmap/v469y2017icp244-249.html
   My bibliography  Save this article

Autoantibody recognition mechanisms of MUC1

Author

Listed:
  • Phillips, J.C.

Abstract

The most cost-effective blood-based, noninvasive molecular early cancer biomarkers are based on p53 epitopes and MUC1 tandem repeats. Here we use dimensionally compressed bioinformatic fractal scaling analysis to compare the two distinct and comparable probes, which examine different sections of the autoantibody population, achieving combined sensitivities of order 50%. We explain the experimental observation that glycosylation does not enhance, and can depress, the sensitivity of MUC1 tandem repeat biomarkers. We propose a possible supplementary MUC1 epitope in the SEA region outside the tandem repeats.

Suggested Citation

  • Phillips, J.C., 2017. "Autoantibody recognition mechanisms of MUC1," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 469(C), pages 244-249.
    • Handle: RePEc:eee:phsmap:v:469:y:2017:i:c:p:244-249
    DOI: 10.1016/j.physa.2016.11.075
    as

    Download full text from publisher

    File URL: http://www.sciencedirect.com/science/article/pii/S0378437116308810
    Download Restriction: Full text for ScienceDirect subscribers only. Journal offers the option of making the article available online on Science direct for a fee of $3,000
    File URL: https://libkey.io/10.1016/j.physa.2016.11.075?utm_source=ideas
    LibKey link: if access is restricted and if your library uses this service, LibKey will redirect you to where you can use your library subscription to access this item
    ---><---

    As the access to this document is restricted, you may want to search for a different version of it.

    References listed on IDEAS

    as
    1. Phillips, J.C., 2016. "Autoantibody recognition mechanisms of p53 epitopes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 451(C), pages 162-170.
    2. Phillips, J.C., 2014. "Fractals and self-organized criticality in proteins," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 415(C), pages 440-448.
    Full references (including those not matched with items on IDEAS)

    Most related items

    These are the items that most often cite the same works as this one and are cited by the same works as this one.
    1. Phillips, J.C., 2017. "Hidden thermodynamic information in protein amino acid mutation tables," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 469(C), pages 676-680.
    2. Phillips, J.C., 2017. "Giant hub Src and Syk tyrosine kinase thermodynamic profiles recapitulate evolution," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 483(C), pages 330-336.
    3. Phillips, J.C. & Moret, Marcelo A. & Zebende, Gilney F. & Chow, Carson C., 2022. "Phase transitions may explain why SARS-CoV-2 spreads so fast and why new variants are spreading faster," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 598(C).
    4. Lahmiri, Salim, 2016. "Clustering of Casablanca stock market based on hurst exponent estimates," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 456(C), pages 310-318.
    5. Marcelo A. Moret & James C. Phillips, 2024. "Why and how did the COVID pandemic end abruptly?," The European Physical Journal B: Condensed Matter and Complex Systems, Springer;EDP Sciences, vol. 97(8), pages 1-4, August.
    6. Phillips, J.C., 2016. "Bioinformatic scaling of allosteric interactions in biomedical isozymes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 457(C), pages 289-294.
    7. Phillips, J.C., 2015. "Similarity is not enough: Tipping points of Ebola Zaire mortalities," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 427(C), pages 277-281.
    8. Phillips, J.C., 2016. "Autoantibody recognition mechanisms of p53 epitopes," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 451(C), pages 162-170.
    9. Filho, A.S. Nascimento & Araújo, M.L.V. & Miranda, J.G.V. & Murari, T.B. & Saba, H. & Moret, M.A., 2018. "Self-affinity and self-organized criticality applied to the relationship between the economic arrangements and the dengue fever spread in Bahia," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 502(C), pages 619-628.
    10. Voorhoeve, Niels & Allan, Douglas C. & Moret, M.A. & Zebende, G.F. & Phillips, J.C., 2018. "Why human milk is more nutritious than cow milk," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 497(C), pages 302-309.
    11. Sachdeva, Vedant & Phillips, James C., 2016. "Oxygen channels and fractal wave–particle duality in the evolution of myoglobin and neuroglobin," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 463(C), pages 1-11.
    12. Phillips, J.C., 2021. "Synchronized attachment and the Darwinian evolution of coronaviruses CoV-1 and CoV-2," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 581(C).
    13. Xu, Xiu-Lian & Shi, Jin-Xuan & Wang, Jun & Li, Wenfei, 2021. "Long-range correlation and critical fluctuations in coevolution networks of protein sequences," Physica A: Statistical Mechanics and its Applications, Elsevier, vol. 562(C).

    Corrections

    All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:eee:phsmap:v:469:y:2017:i:c:p:244-249. See general information about how to correct material in RePEc.

    If you have authored this item and are not yet registered with RePEc, we encourage you to do it here. This allows to link your profile to this item. It also allows you to accept potential citations to this item that we are uncertain about.

    If CitEc recognized a bibliographic reference but did not link an item in RePEc to it, you can help with this form .

    If you know of missing items citing this one, you can help us creating those links by adding the relevant references in the same way as above, for each refering item. If you are a registered author of this item, you may also want to check the "citations" tab in your RePEc Author Service profile, as there may be some citations waiting for confirmation.

    For technical questions regarding this item, or to correct its authors, title, abstract, bibliographic or download information, contact: Catherine Liu (email available below). General contact details of provider: http://www.journals.elsevier.com/physica-a-statistical-mechpplications/ .

    Please note that corrections may take a couple of weeks to filter through the various RePEc services.

    IDEAS is a RePEc service. RePEc uses bibliographic data supplied by the respective publishers.